Article Per Year (5 Year)
p-Index From 2020 - 2025
0
P-Index
This Author published in this journals
All Journal Jurnal Ilmu Kefarmasian Indonesia
HARI PURNOMO
UNIVERSITAS GADJAH MADA
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Synthesis and Structure Elucidation of 1,3 bis(p-Hydroxyphenyl)urea HARI PURNOMO; UMAR ANGGARA JENIE; AGUNG ENDRO NUGROHO; HARNO DWI PRANOWO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 1 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (706.071 KB)

Abstract

Paracetamol is a well known and commonly used analgesic-antipyretical agent. However, it exhibits hepatotoxic side effect if used for the long term or using exessive dose (10-15 g for single dose). A new compound of 1.3 bis (p-hydroxyphenyl)urea (code-name as HP2009) is an analgesic agent, and it is predicted that its hepatotoxic side effect is lower than that of paracetamol. The compound HP2009 was succesfully synthesized. The result showed that by using molar ratios of p-aminophenol and urea 2:9.5, pH 1 for reaction condition, refluxing for about 1 hr and evaporating time was set up for 30 minutes, the yield of HP 2009 will be 99.49%. The crystals obtained was characterized using spectroscopic methods, and showed undoubtedly that the product was 1.3 bis(p-hydroxyphenyl)urea.
Co-Authors Agung Endro Nugroho Harno Dwi Pranowo Umar Anggara Jenie