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All Journal Jurnal Ilmu Kefarmasian Indonesia
YOSHINOSUKE USUKI
FACULTY OF SCIENCE OSAKA CITY UNIVERSITY
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Sintesis Analog 3-0-Benzylstentorin sebagai Prekursor untuk Kerangka Dasar Blepharismin TENI ERNAWATI; YOSHINOSUKE USUKI; HIDEO IIO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 10 No 1 (2012): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

A Method for the synthesis of precursor for the basic skeleton of blepharismin and structural analog was described. Such compound is identified as potential drug for the treatment of antiviral and photodynamic therapy. Benzyl stentorin analog as the basic skeleton of blepharismin was effectively synthesized via reaction one of hydroxyl groups in bianthraquinone derivative with p-methoxybenzylchloride in the presence of potassium carbonate as base. Dimerization of bromo anthraquinone derivative produced dimmer in 55% while the formation of compounds analogous of 3-0-benzylstentorin resulted in 70% yield.
Co-Authors HIDEO IIO TENI ERNAWATI