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All Journal Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Ilmu Kefarmasian Indonesia
MUHAMMAD HANAFI
LEMBAGA ILMU PENGETAHUAN INDONESIA
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Journal : Jurnal Ilmu Kefarmasian Indonesia

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Desain, Sintesis Dan Uji Sitotoksitas analog UK-3A: Hidroksipikolinil Dioktil Glutamat Ester YULIA ANITA; MUHAMMAD HANAFI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 9 No 1 (2011): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Antibiotic UK 3A had been isolated as a minor component from the mycelium of Streptomyces sp. 517-0. It was elucidated as a nine-member dilactone ring derivative. To produce an analog of UK-3A, i.e. hydroxypicolinil dioctyl glutamic ester, was synthesized from L glutamic acid and octanol, and the product was then reacted with 3-hydroxypicolinic acid and dioctyl glutamic ester. The tinal product was identified by 1H and 13C FT NMR, FT-IR spectrophotometry, and LC-MS. The it was tested for cytotoxic activity against P388 Murine Leukemia cells. The results showed that the 3-hydroxypicolinyl dioctyl glutamic ester has higher inhibition activity against P388 leukemia cells with IC50 value of 9.80 µg/mL than the activity of UK 3A with IC50 value of 38.4 µg/mL.
Co-Authors Berna Elya Martha, Septiani YULIA ANITA