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All Journal JFIOnline Bioscientist : Jurnal Ilmiah Biologi Jurnal Natural
Nurdin Saidi
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Syiah Kuala University, Banda Aceh, 23111
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Education Energy Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Physics Social Sciences

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ISOLASI SENYAWA ALKALOID DARI TUMBUHAN Cryptocarya bracteolata (LAURACEAE) Saidi, Nurdin; Morita, Hiroshi; Litaudon, Marc; Mukhtar, Mat Ropi; Awang, Khalijah; Hadi, A. Hamid A.
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 6, No 1 (2012)
Publisher : Indonesian Research Gateway

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Abstract

Isolation of alkaloids from the bark of C. bracteolata Gamb yielded two compounds ofaporphines alkaloid, (+)-Lirioferine and (+)-Bracteoline. The extraction of the bark wascarried out by maceration, and isolation was carried out by column chromatography.Structural elucidation was established through several spectroscopic methods, such as 1DNMR(1H, 13C, DEPT), 2D-NMR (COSY, HMQC, HMBC), UV, IR, MS and comparison withthe published data.ABSTRAKDua senyawa alkaloid jenis aporfin, yaitu (+)-Lirioferin dan (+)-Bracteolin telah diisolasi darikulit batang C. Bracteolata. Ekstraksi senyawa dilakukan menggunakan cara maserasi danisolasi dengan kromatografi kolom. Elusidasi struktur dilakukan dengan berbagai jenisspektroskopi, meliputi 1D-NMR (1H, 13C, DEPT), 2D-NMR (COSY, HMQC, HMBC), UV, IR,EIMS dan perbandingan data senyawa yang sudah dipublikasi sebelumnya.
ISOLASI SENYAWA ALKALOID DARI TUMBUHAN Cryptocarya bracteolata (LAURACEAE) Saidi, Nurdin; Morita, Hiroshi; Litaudon, Marc; Mukhtar, Mat Ropi; Awang, Khalijah; Hadi, A. Hamid A.
Jurnal Farmasi Indonesia Vol 6, No 1 (2012)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v6i1.92

Abstract

Isolation of alkaloids from the bark of C. bracteolata Gamb yielded two compounds ofaporphines alkaloid, (+)-Lirioferine and (+)-Bracteoline. The extraction of the bark wascarried out by maceration, and isolation was carried out by column chromatography.Structural elucidation was established through several spectroscopic methods, such as 1DNMR(1H, 13C, DEPT), 2D-NMR (COSY, HMQC, HMBC), UV, IR, MS and comparison withthe published data.ABSTRAKDua senyawa alkaloid jenis aporfin, yaitu (+)-Lirioferin dan (+)-Bracteolin telah diisolasi darikulit batang C. Bracteolata. Ekstraksi senyawa dilakukan menggunakan cara maserasi danisolasi dengan kromatografi kolom. Elusidasi struktur dilakukan dengan berbagai jenisspektroskopi, meliputi 1D-NMR (1H, 13C, DEPT), 2D-NMR (COSY, HMQC, HMBC), UV, IR,EIMS dan perbandingan data senyawa yang sudah dipublikasi sebelumnya.
Antioxidant ativity of dichloromethane extract from cocoa pod husk (Theobroma cacao L.) FEBRINA, RESA VERNIA; YAHYA, MUSTANIR; GINTING, BINAWATI; SAIDI, NURDIN
Jurnal Natural Volume 24 Number 2, June 2024
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v24i2.36174

Abstract

Theobroma cacao L. is a plant that is reported to have strong antioxidant potential. A study was carried out to determine the antioxidant activity of dichloromethane extract of cocoa pod husk using 1,1-diphenyl-2-picrylhydrazyl (DPPH). The cocoa pod husk was macerated using n-hexane, ammonia-dichloromethane, and methanol. The TCD extract of cocoa pod husk showed the lowest IC50 value of 14.59 0.54 ppm based on the DPPH inhibition assay. The dichloromethane extract was isolated by gravity column chromatography with Silica gel G60 as the stationary phase andn-hexane: ethyl acetate as the mobile phase (gradient elution system). Fractions with identical staining patterns were combined into six fractions (TCD 1-TCD 6). The TCD 6 showed the lowest IC50 value of 127.05 0.54 ppm according to the DPPH inhibition assay. Based on the TLC results, TCD 4 was further isolated and four fractions (TCD 4.1 to TCD 4.4) were obtained. The TCD 4.4 had the lowest IC50 value (38.66 0.96 ppm).The TCD extract showed the presence of the dominant compound, -sitosterol, as determined by GC-MS analysis.
Tren Kejadian Dengue (Incidence Rate) dan Kematian Akibat Dengue (Case Fatality Rate) di Indonesia Meyrita, Meyrita; Suwarno, Suwarno; Saidi, Nurdin; Razi, Nanda Muhammad
Bioscientist : Jurnal Ilmiah Biologi Vol. 11 No. 2 (2023): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v11i2.9500

Abstract

Dengue Hemorrhagic Fever (DHF) is a disease that currently has significant morbidity and mortality rates. In Indonesia, the trend of DHF cases has increased and decreased every year. This study aims to analyze the development of dengue cases by considering two indicators, namely dengue incidence rate and dengue case fatality rate (CFR) during the period 2012-2022, to know the pattern of dengue disease in Indonesia, and evaluate the government's target in handling dengue cases based on IR and CFR rates. The data used is secondary data obtained from the 2021 Indonesian Health Profile and the 2022 Dengue Fever Annual Report. IR and CFR data were analyzed using Microsoft Excel which will be interpreted in the form of graphs to illustrate the trends and patterns of DHF cases in Indonesia, IR maps in 2021 and 2022 were analyzed using ArcGIS software. Based on the results of the analysis, the development of dengue cases during the period 2012-2022 experienced a misalignment between the increasing trend of IR and CFR. The IR value experienced significant fluctuations from 37.3 per 100,000 population in 2012 to 52.07 per 100,000 population in 2022, while the CFR value during the period 2012-2022 tended to decrease from 0.90% (2012) to 0.86% (2022). This pattern reflects the complex dynamics of DHF epidemiology, where an increase in cases is not always followed by an increase in fatalities. The IR and CFR achievements for 2022 have not met the government's expectations, with only 16% of districts/cities having IR values ≤ 10/100,000, while the CFR value reached 0.86%, slightly above the set target of 0.7%.
Co-Authors A. Hamid A. Hadi Binawati Ginting Febrina, Resa Vernia Hiroshi Morita Khalijah Awang Marc Litaudon Mat Ropi Mukhtar Meyrita, Meyrita Nanda Muhammad Razi Suwarno Suwarno Yahya, Mustanir