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All Journal JFIOnline Fullerene Journal of Chemistry Bioscientist : Jurnal Ilmiah Biologi Jurnal Natural Malacca Pharmaceutics Biosainsdik: Biologi Sains dan Kependidikan
Nurdin Saidi
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Syiah Kuala University, Banda Aceh, 23111
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Energy Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Physics Social Sciences Other

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ISOLASI SENYAWA ALKALOID DARI TUMBUHAN Cryptocarya bracteolata (LAURACEAE) Saidi, Nurdin; Morita, Hiroshi; Litaudon, Marc; Mukhtar, Mat Ropi; Awang, Khalijah; Hadi, A. Hamid A.
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 6, No 1 (2012)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Isolation of alkaloids from the bark of C. bracteolata Gamb yielded two compounds ofaporphines alkaloid, (+)-Lirioferine and (+)-Bracteoline. The extraction of the bark wascarried out by maceration, and isolation was carried out by column chromatography.Structural elucidation was established through several spectroscopic methods, such as 1DNMR(1H, 13C, DEPT), 2D-NMR (COSY, HMQC, HMBC), UV, IR, MS and comparison withthe published data.ABSTRAKDua senyawa alkaloid jenis aporfin, yaitu (+)-Lirioferin dan (+)-Bracteolin telah diisolasi darikulit batang C. Bracteolata. Ekstraksi senyawa dilakukan menggunakan cara maserasi danisolasi dengan kromatografi kolom. Elusidasi struktur dilakukan dengan berbagai jenisspektroskopi, meliputi 1D-NMR (1H, 13C, DEPT), 2D-NMR (COSY, HMQC, HMBC), UV, IR,EIMS dan perbandingan data senyawa yang sudah dipublikasi sebelumnya.
ISOLASI SENYAWA ALKALOID DARI TUMBUHAN Cryptocarya bracteolata (LAURACEAE) Saidi, Nurdin; Morita, Hiroshi; Litaudon, Marc; Mukhtar, Mat Ropi; Awang, Khalijah; Hadi, A. Hamid A.
Jurnal Farmasi Indonesia Vol 6, No 1 (2012)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v6i1.92

Abstract

Isolation of alkaloids from the bark of C. bracteolata Gamb yielded two compounds ofaporphines alkaloid, (+)-Lirioferine and (+)-Bracteoline. The extraction of the bark wascarried out by maceration, and isolation was carried out by column chromatography.Structural elucidation was established through several spectroscopic methods, such as 1DNMR(1H, 13C, DEPT), 2D-NMR (COSY, HMQC, HMBC), UV, IR, MS and comparison withthe published data.ABSTRAKDua senyawa alkaloid jenis aporfin, yaitu (+)-Lirioferin dan (+)-Bracteolin telah diisolasi darikulit batang C. Bracteolata. Ekstraksi senyawa dilakukan menggunakan cara maserasi danisolasi dengan kromatografi kolom. Elusidasi struktur dilakukan dengan berbagai jenisspektroskopi, meliputi 1D-NMR (1H, 13C, DEPT), 2D-NMR (COSY, HMQC, HMBC), UV, IR,EIMS dan perbandingan data senyawa yang sudah dipublikasi sebelumnya.
Antioxidant ativity of dichloromethane extract from cocoa pod husk (Theobroma cacao L.) FEBRINA, RESA VERNIA; YAHYA, MUSTANIR; GINTING, BINAWATI; SAIDI, NURDIN
Jurnal Natural Volume 24 Number 2, June 2024
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v24i2.36174

Abstract

Theobroma cacao L. is a plant that is reported to have strong antioxidant potential. A study was carried out to determine the antioxidant activity of dichloromethane extract of cocoa pod husk using 1,1-diphenyl-2-picrylhydrazyl (DPPH). The cocoa pod husk was macerated using n-hexane, ammonia-dichloromethane, and methanol. The TCD extract of cocoa pod husk showed the lowest IC50 value of 14.59 0.54 ppm based on the DPPH inhibition assay. The dichloromethane extract was isolated by gravity column chromatography with Silica gel G60 as the stationary phase andn-hexane: ethyl acetate as the mobile phase (gradient elution system). Fractions with identical staining patterns were combined into six fractions (TCD 1-TCD 6). The TCD 6 showed the lowest IC50 value of 127.05 0.54 ppm according to the DPPH inhibition assay. Based on the TLC results, TCD 4 was further isolated and four fractions (TCD 4.1 to TCD 4.4) were obtained. The TCD 4.4 had the lowest IC50 value (38.66 0.96 ppm).The TCD extract showed the presence of the dominant compound, -sitosterol, as determined by GC-MS analysis.
Tren Kejadian Dengue (Incidence Rate) dan Kematian Akibat Dengue (Case Fatality Rate) di Indonesia Meyrita, Meyrita; Suwarno, Suwarno; Saidi, Nurdin; Razi, Nanda Muhammad
Bioscientist : Jurnal Ilmiah Biologi Vol. 11 No. 2 (2023): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v11i2.9500

Abstract

Dengue Hemorrhagic Fever (DHF) is a disease that currently has significant morbidity and mortality rates. In Indonesia, the trend of DHF cases has increased and decreased every year. This study aims to analyze the development of dengue cases by considering two indicators, namely dengue incidence rate and dengue case fatality rate (CFR) during the period 2012-2022, to know the pattern of dengue disease in Indonesia, and evaluate the government's target in handling dengue cases based on IR and CFR rates. The data used is secondary data obtained from the 2021 Indonesian Health Profile and the 2022 Dengue Fever Annual Report. IR and CFR data were analyzed using Microsoft Excel which will be interpreted in the form of graphs to illustrate the trends and patterns of DHF cases in Indonesia, IR maps in 2021 and 2022 were analyzed using ArcGIS software. Based on the results of the analysis, the development of dengue cases during the period 2012-2022 experienced a misalignment between the increasing trend of IR and CFR. The IR value experienced significant fluctuations from 37.3 per 100,000 population in 2012 to 52.07 per 100,000 population in 2022, while the CFR value during the period 2012-2022 tended to decrease from 0.90% (2012) to 0.86% (2022). This pattern reflects the complex dynamics of DHF epidemiology, where an increase in cases is not always followed by an increase in fatalities. The IR and CFR achievements for 2022 have not met the government's expectations, with only 16% of districts/cities having IR values ≤ 10/100,000, while the CFR value reached 0.86%, slightly above the set target of 0.7%.
Evaluating the Effects of Young Areca catechu Seed Extract on FSH and Testosterone Levels in Male Rats: Insights into Natural Anti-Fertility Agents Noviyanti, Noviyanti; Sugito, Sugito; Akmal, Muslim; Saidi, Nurdin
Malacca Pharmaceutics Vol. 4 No. 1 (2026): March 2026
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v4i1.338

Abstract

Male participation in contraception remains limited worldwide because few safe and acceptable male contraceptive options exist. Natural products are being explored as potential regulators of male reproductive hormones. Areca catechu (areca nut), traditionally used in Southeast Asia, contains phytochemicals that may influence reproductive function. This study evaluated the effects of the ethanolic extract of young A. catechu seeds on serum follicle-stimulating hormone (FSH) and testosterone levels in male Wistar rats. Twenty-five rats were randomly assigned to five groups (0, 20, 40, 60, and 80 mg/kgbody weight) and treated daily for 48 days. Serum FSH and testosterone were measured by ELISA and analyzed by one-way ANOVA with Duncan’s post-hoc test. Mean FSH and testosterone values varied across doses, with the 40 mg/kg group showing the highest means (10.001 ± 10.413 ng/mL and 2.196 ± 1.254 ng/mL, respectively), but no statistically significant differences were detected for either hormone (FSH p = 0.043; testosterone p = 0.425). The results provide preliminary, hypothesis-generating evidence that the extract may influence the hypothalamic–pituitary–gonadal axis; however, any role in male fertility regulation remains unproven. Larger studies including sperm-quality assessment, mechanistic analyses, and toxicological evaluation are required before considering potential applications in male reproductive health.
PHYTOCHEMICAL CONTENT AND PHARMACOLOGICAL POTENTIAL OF Melia azedarach L. AS A COMPREHENSIVE STUDY Aini, Qurratu; Saidi, Nurdin
Jurnal Biologi Sains dan Kependidikan Vol 5, No 2 (2025): NOVEMBER: BIOSAINSDIK : JURNAL BIOLOGI SAINS DAN KEPENDIDIKAN
Publisher : Prodi Tadris Biologi Fakultas Agama Islam Universitas Muhammadiyah Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37598/biosainsdik.v5i2.2579

Abstract

Melia azedarach L., widely known as chinaberry or mindi, is a member of the Meliaceae family that has long been utilized in traditional medicine to treat various ailments such as fever, infections, and diabetes. This study provides a comprehensive review of the phytochemical constituents and pharmacological potential of M. azedarach L. based on a systematic analysis of national and international scientific literature. The findings reveal that the plant contains diverse secondary metabolites including flavonoids (rutin, quercetin), limonoids (salannin, nimbolinin), triterpenoids, phenolic acids, phytosterols, and essential oils. These bioactive compounds contribute to a wide range of biological activities such as antimicrobial, anti-inflammatory, antioxidant, anticancer, antiviral, and antidiabetic effects. Recent studies also highlight its anti-SARS-CoV-2 and immunomodulatory potential through mechanisms involving enzyme inhibition, oxidative stress induction in pathogens, and apoptosis activation in cancer cells. Therefore, Melia azedarach L. represents a promising natural source for the development of phytopharmaceutical products, although further preclinical and clinical studies are necessary to confirm its safety and therapeutic efficacy. 
Fractionation, Purification, and Toxicity of Methanolic Cacao Pod Husk Extract (Theobroma cacao L.) Purnama, Agnia; Yahya, Mustanir; Ginting, Binawati; Saidi, Nurdin; Afifi, Muhammad Ridha; Maghfirah, Ruhul; Farida, Mutia; Ikhsan, Ikhsan
Jurnal Kimia Fullerene Vol 11 No 2: Fullerene Journal Of Chemistry
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37033/fjc.v11i2.772

Abstract

Cacao (Theobroma cacao, L.) is a plantation product that has good prospects, but its processing produces a by-product in the form of cacao pod husks that have not been optimally utilized. This study aims to analyze the toxicity of methanol extracts, fractions, and subfractions of cacao pod husks using the Brine shrimp lethality test (BSLT) assay, and to purify active compounds using gravity column chromatography and thin-layer chromatography (TLC). The fractionation process of the methanol extract produced 5 fractions and 4 subfractions. The results of the toxicity analysis showed that the TCM 2 fraction and the TCM 2.1 subfraction had the highest toxicity, with IC₅₀ values of 38.68 ppm and 28.85 ppm, respectively. Further purification process produced a single isolate identified as a terpenoid compound. The results of this study indicate that cacao pod husks have the potential to serve as a natural source of toxicity and can be developed for use in the pharmaceutical field.
Co-Authors A. Hamid A. Hadi Afifi, Muhammad Ridho Binawati Ginting Febrina, Resa Vernia Hiroshi Morita Ikhsan Ikhsan Khalijah Awang Maghfirah, Ruhul Marc Litaudon Mat Ropi Mukhtar Meyrita, Meyrita Muslim Akmal Mutia Farida, Mutia Nanda Muhammad Razi Noviyanti Noviyanti, Noviyanti Purnama, Agnia QURRATU AINI Sugito - Suwarno Suwarno Yahya, Mustanir