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PENGARUH DEPOMEDROKSI PROGESTERON ASETAT (DMPA) TERHADAP EKSPRESI ESTROGEN RESEPTOR ALPHA (ER-?) PADA RATTUS NOVERGICUS: Pengaruh Depomedroksi Progesteron Asetat (DMPA) Terhadap Ekspresi Estrogen Reseptor Alpha (Er-?) Pada Rattus Novergicus Rizki Fitrianingtyas; Ernawati Anggreni
Jurnal Ilmiah Kebidanan (Scientific Journal of Midwifery) Vol. 5 No. 1 (2019): JIKeb | Maret 2019
Publisher : LPPM - STIKES Pemkab Jombang

Salah satu metode kontrasepsi yang dianggap cukup ideal adalah kontrasepsi suntik Depo Medroksiprogesteron Asetat (DMPA). Kontrasepsi suntik DMPA ini adalah salah satu jenis kontrasespi suntikan yang hanya mengandung progestin saja dan disuntikkan setiap tiga bulan. Perempuan yang telah menggunakan DMPA selama suntikan pertama dan kedua mempunyai histologi endometrium yang atropi, penurunan kepadatan microvaskuler, epitelium menjadi tipis, mengecilnya kelenjar dan meluas, dinding pembuluh darah yang tipis. Rata-rata 60 % mantan akseptor sudah hamil dalam waktu 1 tahun dan lebih dari 90 % dalam waktu 2 tahun. Tujuan Penelitian ini untuk membuktikan apakah DMPA dapat mempengaruhi Ekspresi Estrogen Receptor-? (ER-?) Pada endometrium Tikus (Rattus Novergicus). Penelitian ini menggunakan true experiment dengan rancangan randomized post test cotrol group design menggunakan 30 ekor tikus betina yang dibagi menjadi 3 kelompok. Kelompok kontrol negatif, , kelompok P1 (Pemberian DMPA selama 1 bulan, kelompok P2 (DMPA selama 2 bulan). Ekspresi ER-? diamati dengan mengunakan metode immunohistochimia. Hasil penelitian menunjukkan bahwa terdapat peningkatan dan berbeda secara signifikan ( p value>0,05) Ekspresi Estrogen Receptor-? (ER-?) terhadap kelompok perlakuan 1 dan perlakuan 2.. Penelitian ini menyimpulkan bahwa pemberian suntikan DMPA mampu menurunkan Ekspresi Estrogen Receptor-? (ER-?). Kata Kunci : DMPA, Ekspresi ER-?,

PENGARUH HIPNOBIRTHING DENGAN TINGKAT KECEMASAN IBU HAMIL DI RSI NASRUL UMMAH LAMONGAN: The Influence of Hipnobirthing for Anxiety Pregnant Women in Nasrul Ummah Lamongan Hospital Rizki Fitrianingtyas
Jurnal Ilmiah Kebidanan (Scientific Journal of Midwifery) Vol. 8 No. 1 (2022): JIKeb | Maret 2022
Publisher : LPPM - STIKES Pemkab Jombang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33023/jikeb.v8i1.999

Kehamilan dan persalinan adalah suatu proses reaksi berantai yang sangat mengagumkan dan membentuk ikatan seumur hidup yang takkan terpisahkan antara orang tua dan janin yang ada dalam kandungan, namun tidak semua wanita memiliki proses kehamilan yang lancar. Hal ini terjadi karena proses dan resiko saat hamil menimbulkan reaksi psikologis seperti kecemasan, dan apabila tidak dikelola dengan baik maka akan berakibat negatif bagi wanita hamil secara fisik maupun mental. Salah satu metode yaang dapat dilakukan untuk menurunkan tingkat kecemasan pada ibu hamil adalah metode relaksasi hypnobirthing. Penelitian ini bertujuan untuk mengetahui adanya pengaruh metode hypnobirthing dalam menurunkan tingkat kecemasan pada ibu hamil. Penelitian ini menggunakan pendekatan metode quasi eksperimen dengan subjek penelitian berjumlah 10 orang, 10 orang pre dan post hypnobithing. Alat ukur yang digunakan adalah skala distress Hypnobirthing Indonesia yang disusun oleh psikiater dan psikolog RSPAD Gatot Subroto, Jakarta dan dapat digunakan oleh praktisi hypnobirthing untuk kepentingan pengukuran. Penelitian mengukur kecemasan pretest dan postest dengan menggunakan uji T test Dan nilai Sig tingkat signifikansi hubungan dengan hasil 0,000 yang artinya signifikan pada level 0,01. kelas hypnobirthing mempunyai emosional yang lebih positif dan tidak mengalami masalah psikologis postpartum dibanding wanita yang tidak mengikuti kelas relaksasi hypnobirthing. Relaksasi sebagai salah satu tekhnik yang telah terbukti dapat mereduksi kecemasan pada berbagai subjek juga telah terbukti efektif mengurangi kecemasan pada ibu hamil Kesimpulannya bahwa hypnobitrhing mampu menurunkan kecemasan pada ibu hamil secara signifikan.

Implementasi Kegel Exercise terhadap Nyeri Menstruasi pada Siswi Kelas X di SMK Indah Christiana; Elmi Nur Hidayati; Rizki Fitrianingtyas
PROFESSIONAL HEALTH JOURNAL Vol 1 No 1 (2019)
Publisher : Pusat Penelitian dan Pengabdian Masyarakat (PPPM) STIKES Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54832/phj.v1i1.96

Dsymenorrhea or abdominal pain is a gynecological complaint because of the imbalance of the hormone progesteon in the blood causing pain that comes from uterine cramps. The nature of the degree of pain varies, ranging from mild to severe, severe pain conditions can interfere with daily activities. One therapy to overcome the problem of menstrual pain is kegel exercise. Kegel exercise is a pelvic floor muscle exercises (ODP). The purpose of this study is to determine the implementation of kegel exercise against menstrual pain in grade X students in SMK Sanyanjung Banyuwangi Year 2017. The design in this study used pre experimental research design with one group pretest and postest design. Technique of collecting data using check list then analyzed by using Wilcoxon test with SPSS 23 for windows with α 0,05. Sampling technique using simple random sampling, With a sample of 30 respondents who aged 15-17 years in SMK Sritanjung Banyuwangi. Based on the results of the study of 30 respondents almost half of 46.7% (14 respondents) before giving kegel exercise experience moderate menstrual pain and almost half of 40% (12 respondents) after being given kegel exercise mild menstrual category pain. From the calculation of SPSS 23 for windows with Wilcoxon test obtained Asymp.Sig (2- tailed) value = 0,000 <α = 0.05 then Ho in reject Ha in receipt which means there is a significant influence on the kegel exercise against menstrual pain. The results of this study are expected to improve the knowledge of respondents in the management of dysmenorrhea by doing kegel exercise to reduce the level of menstrual pain.

The Relationship of Emotional Level with the Menstrual Cycle in Adolescent Women Yuni Handayani; Rizki Fitrianingtyas; Yuningsih Yuningsih; Kustin Kustin
Jurnal MID-Z (MIDWIFERI ZIGOT) Vol 5 No 2 (2022): NOVEMBER
Publisher : Universitas Islam Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56013/jurnalmidz.v5i2.1686

Emotions are related to emotional expression or profound changes that accompany emotions, characterizing individuals who are easily aroused to display emotional behavior. The factors that affect the menstrual cycle are estrogen production, nutritional status, stress factors, regular exercise, emotional changes, smoking and taking drugs. Emotional changes due to a stressor have been associated with hormonal fluctuations during the menstrual cycle. Menstrual cycle is a menstrual cycle that women experience every month starting from the first day of menstruation. In a disturbed psychological state, activation of the limbic system occurs. The menstrual cycle varies, mostly 90% of women have a cycle of 25-35 days and only 10-15% have a cycle length of 28 days. The design of this study uses a correlation with a cross sectional approach. The population is 50 young women. This study uses 44 respondents as a sample using the simple random sampling technique in SMK dr. Soebandi. The results showed maladaptive emotional levels (68.2%) and abnormal menstrual cycles (68.2%). Test data analysis using Chi Square with p-value 0.004 < (0.05) which means that there is a relationship between emotional levels and the menstrual cycle in adolescent girls. It is recommended to add information and insight to the public about the relationship between emotional levels and the menstrual cycle.

Gambaran Faktor-Faktor yang Berhubungan dengan Perilaku Seksual Remaja di SMP Kabupaten Jember Rizki Fitrianingtyas; Yuni Handayani; Zaida Mauludiyah
ARTERI : Jurnal Ilmu Kesehatan Vol 4 No 1 (2022): November
Publisher : Puslitbang Sinergis Asa Professional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37148/arteri.v4i1.238

Sexual behavior is a major problem related to various cases of juvenile delinquency. Cases of juvenile delinquency, especially sexual problems that occur from year to year show an increase. This research was conducted with the aim of knowing the description of the factors associated with adolescent sexual behavior. The design of this research is descriptive research. The research variables adolescent knowledge, adolescent attitudes, and adolescent sexual behavior. The research was conducted at SMP N 4 Jember. The research population was all students of SMP N 4 Jember, Jember City with a simple random sampling technique. Research data were collected through observation, questionnaires, and documentation methods. The research data was then processed and analyzed descriptively. The results showed that 40% of students had good knowledge, 55% had sufficient knowledge, 5% lacked knowledge. Sources of information of respondents were 11.7% from magazines/newspapers, 44.1% from television, 17.7% from the internet, from teachers 23.5%. In the attitude calculation results, 100 percent have negative sexual attitudes. A total of 37.7% of respondents had a girlfriend and 100% had held hands, 15% had kissed on the cheek, 5% had kissed on the lips. The better the level of adolescent knowledge, the healthier sexual behavior because the knowledge possessed by adolescents will form a good personality and have an impact on good daily behavior, including adolescent behavior towards premarital sex. Thus increasing knowledge about reproductive health is very important to form good sexual attitudes and behavior.

Effect of Depo Medroxsi Progesteron Acetat (DMPA) on Indeks Apoptosis Ovarium in The Exposed Rated Endometrium (Rattus Novergicus) Rizki Fitrianingtyas; Indah Christiana
Jurnal Kesehatan dr. Soebandi Vol 10 No 2 (2022): Jurnal Kesehatan dr. Soebandi
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jkds.v10i2.384

Introduction: Depo Medroxiprogesterone Asetat is the type contraceptive containing only progestin are granted every 3 months that which are considered most effective and regarded with few side effects directly. Side effects long-term that of them , drought the vagina, decrease in the libido , decrease Bone Mineral Density .This caused by because of a decrease in function in the ovary due to the occurrence of apoptosis. Objective: To prove the influence of DMPA with index apoptosis on the ovaries Rattus Norvegicus based on for too long a time exposure to. Methods: Design that is used of these tests are true experiment with the selection in the entire house hold sample use the design of randomized post test drives in cotrol group including on the instrument types. Samples from 30 the tail of a rat males or the two females was classified into 3 group . Group stage matches at first one is the control group (KN) , a second group are to supply 1 treatment being handed out by the provision of therapy DMPA every 1 weeks for rp as long as 1 the month and within a group the third of which was included in the research sample oil which is injected DMPA every once a week for 2 months. Apoptosis index observed with a method of tunel assay kit and a cell that mediate apoptosis in an analysis using a microscope olympus and counting olyvia use . Result : The research results show (p value < 0.05) which means differ significantly . Apoptosis index to 2 are more large treatment from a group 1 and the group one standings larger than the express group control . Estradiol serves as a control an increase in antioxidant genes an enzyme that is an enzyme superoksidase dismutase (SOD) which was with in the mitochondria as a result estradiol can not fulfill their function as antioxidant .The state of this caused the oksidative strees characterized the emergence of free radical. Free radical causes oxidative modification cellular macromolecules , impeding the function of proteins and increase mediate apoptosis. Conclusion: the injections DMPA able to increase apoptosis index in the ovary.

Implementasi Kegel Exercise terhadap Nyeri Menstruasi pada Siswi Kelas X di SMK Indah Christiana; Rizki Fitrianingtyas; Elmi Nur Hidayati
PROFESSIONAL HEALTH JOURNAL Vol. 1 No. 1 (2019)
Publisher : Pusat Penelitian dan Pengabdian Masyarakat (PPPM) STIKES Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54832/phj.v1i1.96

Dsymenorrhea or abdominal pain is a gynecological complaint because of the imbalance of the hormone progesteon in the blood causing pain that comes from uterine cramps. The nature of the degree of pain varies, ranging from mild to severe, severe pain conditions can interfere with daily activities. One therapy to overcome the problem of menstrual pain is kegel exercise. Kegel exercise is a pelvic floor muscle exercises (ODP). The purpose of this study is to determine the implementation of kegel exercise against menstrual pain in grade X students in SMK Sanyanjung Banyuwangi Year 2017. The design in this study used pre experimental research design with one group pretest and postest design. Technique of collecting data using check list then analyzed by using Wilcoxon test with SPSS 23 for windows with α 0,05. Sampling technique using simple random sampling, With a sample of 30 respondents who aged 15-17 years in SMK Sritanjung Banyuwangi. Based on the results of the study of 30 respondents almost half of 46.7% (14 respondents) before giving kegel exercise experience moderate menstrual pain and almost half of 40% (12 respondents) after being given kegel exercise mild menstrual category pain. From the calculation of SPSS 23 for windows with Wilcoxon test obtained Asymp.Sig (2- tailed) value = 0,000 <α = 0.05 then Ho in reject Ha in receipt which means there is a significant influence on the kegel exercise against menstrual pain. The results of this study are expected to improve the knowledge of respondents in the management of dysmenorrhea by doing kegel exercise to reduce the level of menstrual pain.

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