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Samekto Wibowo Samekto Wibowo
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Penicillin Dalam Pengobatan Infeksi Meningococci Samekto Wibowo, Samekto Wibowo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 6, No 02 (1974)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Banyak obat yang dipakai dalam pengobatan infeksi meningococci, di antaranya ialah penicillin. Obat pilihan bukan saja harus mempunyai effektivitas terhadap microorganismenya, juga harus mempunyai kemampuan masuk dalam cairan cerebrospinal. Inflamasi meninges memperbesar pemasukan obat ke dalam cairan itu.Banyak obat masuk dalam golongan penicillin, tapi semuanya termasuk golongan yang sukar menembus barrier darah-otak. Amoxycillin, suatu preparat penicillin semisynthetis yang baru, mempunyai kemampuan masukdalam cairan cerebrospinal yang lebih besar. lagi bila diberikan secara infus intraveneus yang lambat. Percobaan telah dilakukan pada anjing. Seandainya hal itu juga berlaku pada manusia, tentulah akan sangat menggembirakan.
The Motor Nerve Conduction Velocity Features of Leprosy Patients in Sardjito Central General Hospital, Yogyakartal) Samekto Wibowo, Samekto Wibowo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 19, No 01 (1987)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Telah diketahui infeksi Mycobacterium leprae dapat menimbulkan gejala neuropati. Kecepatan Hantar Saraf Tepi (KHST) dapat menunjukkan level neuropati. Pada penelitian ini pemeriksaan KHST motorik dikerjakan pada sejumlah penderita lepra yang berobat jalan di Rumah Sakit Umum Pusat Sardjito, Yogyakarta. Gambaran KHST motoriknya menunjukkan terdapatnya gejala neuropad. Saraf yang terkena lehih berm nampaknya adalah n. radialis, n. peroneus dan n. tibialis. Di camping cara-cara lain, pemeriksaan elektromiografi kiranya dapat bermanfaat untuk memantau penyembuhan gejala neuropati. Key Words: leprosy — neuropathy — motor latency — nerve conduction velocity — electromyography
Farmakologi Klinik Suatu Introduksi Samekto Wibowo, Samekto Wibowo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 7, No 02 (1975)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Perkembangan keadaan memerlukan bidang pengetahuan Baru yakni: farmakologi klinik. Hal yang perlu diperhatikan ialah fungsi, organisasi dan keperluan-keperluannya. Hanya saja, sebelum putusan ke arah pembinaan farmakologi klinik haruslah didapat persesuaian dalam hal kebutuhannya, baik bagi rumah sakit maupun bagi fakultas kedokteran.Fungsi harus dijelaskan dulu, fungsi akademik dalam fakultas kedokteran dan fungsi service dalam rumah sakit. Adanya laboratorium farmakologi klinik dan service klinik akan banyak menghemat tenaga dan alat yang akan diperlukan oleh sebuah rumah sakit. Daripada tiap departemen rumah sakit membuat laboratorium sendiri-sendiri, akan lebih baik ada laboratorium sentral farmakologi klinik. Dan harus diingat, bahwa nanti mencakup pula status administratif, perencanaan staf tehnicus dan professionil, ruang kantor dan laboratorium serta fasilitas rumah sakit termasuk out-patient dan tentu saja dana (Wardell, 1974).Melihat kondisi kebutuhan yang sama, nampaknya Indonesia sudah harus mulai berfikir ke arah itu. Jalan awal yang paling sederhana ialah memberikan pelajaran farmakologi klinik pada mahasiswa. Dari sini perkembangan lebih lanjut farmakologi klinik akan dibina.
Pengobatan Asthma Bronchiale Dan Pemakaian Corticosteroid Samekto Wibowo, Samekto Wibowo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 6, No 03 (1974)
Publisher : Universitas Gadjah Mada

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Abstract

Survai mengenai tempat perkembang-biakan nyamuk Aedes aegypti di Daerah Istimewa Yogyakarta telah dilakukan oleh Bagian Parasitologi Fakultas Kedokteran dan Fakultas Biologi Universitas Gadjah Mada pada tgl. 27 Maret sampai dengan 30 April 1973.Dari hasil survai ternyata bahwa nyamuk Aedes aegypti lebih banyak bersarang di kota daripada di pedesaan. Hampir 100% dari desa atau kampung di mana terdapat penderita suspect D. H. F. terbukti positip Aedes aegypti. Nyamuk ini kebanyakan berkembang biak dalam tempayan (di dalam rumah lebih banyak daripada di luar rumah) dan hanya sedikit di pot-pot bunga ataupun di lobang-/obang pohon; jadi tidak seperti sifat aselinya.Dengan laporan di atas ini diharapkan agar penanggulangan penyakit D. H. F., khususnya pemberantasan vektor Aedes aegypti dapat berhasil dengan memuaskan.
The association of acety/ation status with the occurrence of autonomic neuropathy: Diabetic neuropathy cases study Samekto Wibowo, Samekto Wibowo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 31, No 02 (1999)
Publisher : Universitas Gadjah Mada

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Abstract

Background: Acetylation is a type of drug metabolism pathway. People can be divided into two groups: rapid acetylators, i.e. those who will acetylate drugs (chemical substances) rapidly, and slow acetylators, i.e. those who will acetylate drugs (chemical substances) slowly. Many studies reported that slow acetylator become more succeptable to certain diseases compared to rapid acetylators. Neuropathy might occur in diabetes mellitus, with the following symtoms mononeuropathy, symmetrical peripheral polyneuropathy and/or autonomic neuropathy.Objective: To study the association between acetylation status with the occurrence of autonomic neuropathy on diabetic neuropathy cases.Methods: An analytical descriptive study involving 140 patients of diabetic neuropathy was conducted at Sardjito Central General Hospital, Yogyakarta, Indonesia.Results: Schellong Test confirmed a definite sympatic neuropathy in 11 (7,9%) patients. The examination of acetylation status revealed that 68% of patients were rapid acetylators, and 32% patients were slow acetylators. Among the patients with autonomic neuropathy, it was found that 64% were slowly acetylators, whereas only 36% were rapid acetylators. Among the patients without autonomic neuropathy, 30,5% were slowly acetylators, whrereas 69,5% were rapid acetylators: this distribution frequency was similar to the normal population.Conclusion: Slow acetylation status had significant association (p<0,05) with the occurrence of autonomic neuropathy. Key words: acetylation status - autonomic neuropathy - diabetic neuropathy - sympatic neuropathy - Schellong Test 
Polytherapy in the management of epilepsy Samekto Wibowo, Samekto Wibowo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 29, No 04 (1997)
Publisher : Universitas Gadjah Mada

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Abstract

Antiepileptic drugs take a dominant role in the management of epilepsy. Although monotherapy has been recommended, polytherapy sometimes is very difficult to be avoided. This study wanted to remind: what factors should be considered in epilepsy polytherapy. Drug-drug interactions and the risk of side effects might occures. Optimal polytherapy was often achieved with drugs that had different mechanism of action, relatively few side effects, high therapeutic indexes, and limited or no drug interactions. To choose the drug groups, the following factors should also be considered, namely: efficacy, safety, suitability and cost of treatment. In short, polytherapy should be rational.Key words: epilepsy - monotherapy - polytherapy - rational use of drugs - drugs infraction
The association between diabetic autonomic neuropathy with thiamine deficiency Samekto Wibowo, Samekto Wibowo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 31, No 03 (1999)
Publisher : Universitas Gadjah Mada

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Abstract

Background: Autonomic neuropathy is a kind of diabetes mellitus complication. Parasympathetic neuropathy occurs first, and then it is followed by sympathetic neuropathy. Autonomic nerves are widely distributed in many organs and systems, including cardiovascular, gastrointestinal, urogenital, thermoregulation, and ocular organs. Therefore, the involvement of those organs will produce certain clinical symptoms related to the functions of the internal organs. On the other hand, thiamine status influences the condition of nerve fibers. Thiamine deficiency may produce nerve impairment.Objective: To discover the association between diabetic autonomic neuropathy with thiamine deficiency. Methods: Diabetes mellitus cases of Sardjito Central General Hospital were involved in this study. Schellong test was used to diagnose autonomic neuropathy. Thiamine status was measured in The Nutrition and Food Laboratory of Gadjah Mada University by determining transketolase enzyme activity as done by Ismadi. Results: One hundred and forty subjects were involved in this study. Eleven subjects (7.9%) suffered from autonomic neuropathy. Thiamine deficiency occured in 60% of autonomic neuropathy subjects. Among the subjects without autonomic neuropathy, 55.6% suffered from thiamine deficiency. The difference was not significant (p> 0.05). Odds Ratio 1,2; 95%Cl 0.32-4,46.Conclusions: Thiamine deficiency was more prominent among diabetic autonomic neuropathy subjects. Nevertheless, diabetic autonomic neuropathy had no significant association (p > 0.05) OR 1.2; 95% CI 0.32-4.46) with thiamine deficiency.Key words: diabetes mellitus - thiamine deficiency - autonomic neuropathy - diabetic autonomic neuropathy - postural hypotension
The association between diabetic autonomic neuropathy with thiamine deficiency Samekto Wibowo Samekto Wibowo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 31, No 03 (1999)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (126.941 KB)

Abstract

Background: Autonomic neuropathy is a kind of diabetes mellitus complication. Parasympathetic neuropathy occurs first, and then it is followed by sympathetic neuropathy. Autonomic nerves are widely distributed in many organs and systems, including cardiovascular, gastrointestinal, urogenital, thermoregulation, and ocular organs. Therefore, the involvement of those organs will produce certain clinical symptoms related to the functions of the internal organs. On the other hand, thiamine status influences the condition of nerve fibers. Thiamine deficiency may produce nerve impairment.Objective: To discover the association between diabetic autonomic neuropathy with thiamine deficiency. Methods: Diabetes mellitus cases of Sardjito Central General Hospital were involved in this study. Schellong test was used to diagnose autonomic neuropathy. Thiamine status was measured in The Nutrition and Food Laboratory of Gadjah Mada University by determining transketolase enzyme activity as done by Ismadi. Results: One hundred and forty subjects were involved in this study. Eleven subjects (7.9%) suffered from autonomic neuropathy. Thiamine deficiency occured in 60% of autonomic neuropathy subjects. Among the subjects without autonomic neuropathy, 55.6% suffered from thiamine deficiency. The difference was not significant (p> 0.05). Odds Ratio 1,2; 95%Cl 0.32-4,46.Conclusions: Thiamine deficiency was more prominent among diabetic autonomic neuropathy subjects. Nevertheless, diabetic autonomic neuropathy had no significant association (p > 0.05) OR 1.2; 95% CI 0.32-4.46) with thiamine deficiency.Key words: diabetes mellitus - thiamine deficiency - autonomic neuropathy - diabetic autonomic neuropathy - postural hypotension
The association of acety/ation status with the occurrence of autonomic neuropathy: Diabetic neuropathy cases study Samekto Wibowo Samekto Wibowo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 31, No 02 (1999)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (149.121 KB)

Abstract

Background: Acetylation is a type of drug metabolism pathway. People can be divided into two groups: rapid acetylators, i.e. those who will acetylate drugs (chemical substances) rapidly, and slow acetylators, i.e. those who will acetylate drugs (chemical substances) slowly. Many studies reported that slow acetylator become more succeptable to certain diseases compared to rapid acetylators. Neuropathy might occur in diabetes mellitus, with the following symtoms mononeuropathy, symmetrical peripheral polyneuropathy and/or autonomic neuropathy.Objective: To study the association between acetylation status with the occurrence of autonomic neuropathy on diabetic neuropathy cases.Methods: An analytical descriptive study involving 140 patients of diabetic neuropathy was conducted at Sardjito Central General Hospital, Yogyakarta, Indonesia.Results: Schellong Test confirmed a definite sympatic neuropathy in 11 (7,9%) patients. The examination of acetylation status revealed that 68%' of patients were rapid acetylators, and 32% patients were slow acetylators. Among the patients with autonomic neuropathy, it was found that 64% were slowly acetylators, whereas only 36% were rapid acetylators. Among the patients without autonomic neuropathy, 30,5% were slowly acetylators, whrereas 69,5% were rapid acetylators: this distribution frequency was similar to the normal population.Conclusion: Slow acetylation status had significant association (p<0,05) with the occurrence of autonomic neuropathy. Key words: acetylation status - autonomic neuropathy - diabetic neuropathy - sympatic neuropathy - Schellong Test 
Polytherapy in the management of epilepsy Samekto Wibowo Samekto Wibowo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 29, No 04 (1997)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (143.524 KB)

Abstract

Antiepileptic drugs take a dominant role in the management of epilepsy. Although monotherapy has been recommended, polytherapy sometimes is very difficult to be avoided. This study wanted to remind: what factors should be considered in epilepsy polytherapy. Drug-drug interactions and the risk of side effects might occures. Optimal polytherapy was often achieved with drugs that had different mechanism of action, relatively few side effects, high therapeutic indexes, and limited or no drug interactions. To choose the drug groups, the following factors should also be considered, namely: efficacy, safety, suitability and cost of treatment. In short, polytherapy should be rational.Key words: epilepsy - monotherapy - polytherapy - rational use of drugs - drugs infraction
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