Widiastuti Samekto
Ilmu Kedokteran Universitas Diponegoro Semarang

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BEBERAPA FAKTOR RISIKO YANG BERPENGARUH TERHADAP KEJADIAN STROKE NON HEMORAGIK (STUDI KASUS DI STROKE CENTER RUMAH SAKIT KHUSUS DAERAH PROPINSI SULAWESI SELATAN) ., Nildawati; Hadisaputro, Suharyo; Samekto, Widiastuti
Jurnal Kesehatan Vol 7, No 2 (2014): Jurnal Kesehatan
Publisher : Kesehatan Masyarakat UIN Alauddin Makassar

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Abstract

Stroke non hemoragik masih menjadi masalah kesehatan masyarakat, berkaitan dengan tingginya angka morbiditas, mortalitas dan disability. Data tahun 2009 menunjukkan bahwa jumlah kunjungan Stroke non hemoragik di RS khusus daerah Propinsi Sulawesi Se-latan mencapai 890. Tujuan Penelitian ini adalah untuk mengetahui beberapa faktor risiko yang berpengaruh terhadap kejadian stroke non hemoragik.Metode Case Control Study dimana kasus adalah pasien stroke non hemoragik yang berkunjung di Stroke Center Rumah Sakit Khusus Daerah Propinsi Sulawesi Selatan antara kurun waktu Januari 2011 hingga April 2012, sedangkan kontrol adalah pasien yang pernah dan sedang dirawat inap dari bangsal penyakit dalam, dalam kurun waktu yang sama dengan kelompok kasus. Data diperoleh dari buku register, catatan medis, serta dilakukan indepth interview.Hasil analisis multivariat menunjukkan bahwa faktor risiko yang terbukti berpengaruh terhadap kejadian stroke non hemoragik adalah riwayat penyakit dalam keluarga (p = 0,004, OR = 3,6, 95%CI = 1,5-8,9), kebiasaan mengkonsumsi alkohol/ballo (p = 0,004, OR = 4,9, 95%CI = 1,8-13,3), stressor psikososial (p = 0,050, OR = 2,9, 95%CI = 1,0-7,9), pola perilaku (p = 0,004, OR = 5,1, 95%CI = 1,7-15,7), diabetes mellitus (p = 0,000, OR = 5,6, 95%CI = 2,5-12,9%), penyakit jantung (p = 0,011, OR = 3,7, 95%CI = 1,3-9,9), dan kebia-saan mengkonsumsi daging (p = 0,008, OR = 6,0, 95%CI = 1,5-22,7).Faktor risiko yang terbukti secara signifikan adalah riwayat penyakit dalam keluarga, kebiasaan mengkonsumsi alkohol, stressor psikososial, pola perilaku tipe A, diabates melli-tus, kelainan jantung, serta kebiasaan mengkonsumsi daging. Perilaku hidup sehat dengan tidak mengkonsumsi alkohol, olah raga secara teratur, makan makanan yang sehat dan kon-sumsi kolesterol yang berimbang serta tidak stress merupakan faktor penting untuk mencegah terjadinya stroke non hemoragik.Kata kunci : Stroke Non Hemoragik, Faktor-Faktor Risiko, Kasus Kontrol.
Green Synthesis of Silver Nanoparticles as a Wound Healing Agent: a Systematic Review of the Biological Activities Priambodo, Galih; Samekto, Widiastuti; Subagio, Agus; Susanto, Hardhono; Dwiantoro, Luky
Indonesian Journal of Medicine Vol. 8 No. 1 (2023)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2023.8.1.612

Abstract

Background:  The implication of nanotechnology includes silver nanoparticles to medical sciences, and has a revolutionary impact on therapeutic and diagnostics management. Many studies reported that silver nanoparticle (AgNPs) application can accelerate the wound healing process. This study aimed to systematically review the biological activities of silver nanoparticles as a wound-healing agent.Subjects and Method:  This article was a systematic review study conducted by searching for articles from online databases such as EBSCO, PubMed, Science Direct, and World Scientific. Populations: laboratory animals; Intervention: green synthesis of silver nanoparticles; Comparison: a standard ointment for wounds such as povidone-iodine, etc; Outcome: wound healing. The independent variable is the green synthesis of silver nanoparticles, and the dependent variable is wound healing. The inclusion criteria for this study were full articles using an experimental study, with the publication year until 2022. The data extraction was focused on the biological activities of silver nanoparticles and reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations for systematic reviews.Results:  A total of 8 articles reviewed in this study were from countries: Egypt, India, Saudi Arabia, Singapore, and China. The green synthesis of AgNPs was accomplished using a natural aqueous extract from leaves such as Azadirachta indica, Tridax procumbens, the combinations of Catharanthus roseus and Azadirachta indica, Scutellaria barbata, the fungus Fusarium verticillioides, or cyanobacterial platforms (ex: Phormidium sp., Synechocystis sp, and arthrospira sp polysaccharides). All studies were animal-based experimental with wounds infected with bacteria and inflicted in regards to the experiment. All trials resulted in favor of the AgNPs ointment treated group compared to the untreated group or the standard ointment group.Conclusion:  Our review suggested that all studies about the efficacy of AgNPs as wound-healing therapy showed positive results.Keywords:  biological activities, silver nanoparticles, wound healing.Correspondence: Galih Priambodo. Faculty of Medicine, Universitas Diponegoro. Jl. Prof. Sudarto, Tembalang, Kec. Tembalang, Kota Semarang, Central Java. Email: g2_37@yahoo.co.id. Mobile: 085229998999.Indonesian Journal of Medicine (2023), 08(01): 100-113https://doi.org/10.26911/theijmed.2023.08.01.10