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All Journal International Journal of Public Health Science (IJPHS) SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Journal of Nutrition and Health Rotasi JURNAL GIZI INDONESIA The Indonesian Biomedical Journal HISTOGRAM: Jurnal Pendidikan Matematika Jurnal Epidemiologi Kesehatan Komunitas Jurnal Riset Rumpun Seni, Desain dan Media (JURRSENDEM)

Heri Nugroho

Staf pengajar bagian Ilmu Penyakit Dalam Fakultas Kedokteran UNDIP Semarang

Author-ID : 333312

Arts Biochemistry, Genetics & Molecular Biology Education Health Professions Mechanical Engineering Medicine & Pharmacology Public Health

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PENGARUH MODEL PEMBELAJARAN LEARNING CYCLE 5E TERHADAP HASIL BELAJAR MATEMATIKA Nugroho, Heri
HISTOGRAM: Jurnal Pendidikan Matematika Vol 2, No 1 (2018): Histogram
Publisher : STKIP Andi Matappa

Penelitian ini bertujuan untuk mengetahui ada tidaknya pengaruh model pembelajaran Learning Cycle 5E terhadap hasil belajar matematika pada materi teorema Pythagoras. Populasi dalam penelitian ini adalah siswa kelas VIII SMP Negeri 2 Tuntang. Pengambilan sampel dilakukan dengan teknik Cluster Random Sampling dan diperoleh siswa kelas VIIIE sebagai kelas eksperimen dan VIIIG sebagai kelas kontrol. Uji beda rerata kemampuan awal siswa dengan menggunakan uji Mann-Whitney menghasilkan nilai signifikansi 0,851 (lebih dari 0,05), artinya kondisi awal kedua kelas seimbang. Hasil uji beda rata-rata mengahasilkan nilai signifikansi sebesar 0,024 (kurang dari 0,05). Hal ini berarti terdapat perbedaan yang signifikan antara rerata kedua kelas, maka disimpulkan terdapat pengaruh model pembelajaran Learning Cycle 5E terhadap hasil belajar matematika bagi siswa kelas VIII SMP Negeri 2 Tuntang.

Faktor Risiko Penyakit Ginjal Kronik Diabetes (PGK-DM) pada Diabetes Mellitus Tipe-2 (Studi di RSUD DR Soedarso Kota Pontianak Provinsi Kalimantan Barat) Rini, Sulistio; Hadisaputro, Suharyo; Lestariningsih, Lestariningsih; Nugroho, Heri; Budijitno, Selamat
Jurnal Epidemiologi Kesehatan Komunitas Vol 3, No 1: Februari 2018
Publisher : Sekolah Pascasarjana Universitas Diponegoro Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (51.096 KB)

Background: Prevalence of type-2 diabetes mellitus have increased signiï¬cantly. The increasing number of people with diabetes has a major impact on the development of chronic diabetic kidney disease. The research was aimed to clarify several risk factors of chronic diabetic kidney disease on type-2 diabetes mellitus (CDK-DM).Method: The research was based on case control study design. The number of respondents was 140 respondents consisting 70 cases and 70 controls that met the criteria of inclusion and exclusion. The cases were patients with type-2 chronic diabetic kidney disease stadium 2-5. The controls were patients with type-2 chronic diabetic kidney disease with blood sugar levels â¥ 200 mg/dL. The data were then analyzed using logistic regression.Results: The result shows that risk factors of chronic diabetic kidney disease in type-2 diabetes mellitus are diabetes in family (OR = 6,732; 95% CI = 2,623- 17,276), high blood pressure (OR =6,760; 95% CI = 2,190- 20,867), lack of physical activities (OR = 4,367 95% CI = 1,823-10,462) and lack of family support (OR = 4,203; 95% CI = 1,437-12,295). The probability of chronic diabetic kidney disease occurrence in type-2 diabetes mellitus when four risk factors exist are96,71%.Conclusion: The host factors have important role of chronic diabetic kidney disease in type 2 diabetes mellitus . The factors proven to be risk factors for occurrence of chronic diabetic kidney disease in type 2 diabetes mellitus were diabetic in the family, Hipertension, poor physical exercise and family Support.

HUBUNGAN ANTARA LINGKAR PINGGANG DENGAN KOMPOSISI LEMAK TUBUH DAN INDEKS MASSA TUBUH: STUDI PADA PENDERITA DIABETES MELITUS TIPE 2 Nurhasanah, Nurhasanah; Muis, Siti Fatimah; Murbawani, Etisa Adi; Probosari, Enny; Nugroho, Heri
JNH (Journal of Nutrition and Health) Vol 7, No 3 (2019): JNH (JOURNAL OF NUTRITION AND HEALTH)
Publisher : Universitas Diponegoro

ABSTRAKLatar belakang: Obesitas merupakan faktor risiko mayor terjadinya diabetes melitus (DM), berhubungan dengan penumpukan jaringan lemak tubuh. Banyak metode untuk mengukur jaringan lemak diantaranya indeks massa tubuh (IMT), lingkar pinggang (LP) dan Bioelectrical impedance analysis (BIA). Distribusi lemak tubuh lebih berperan dalam menentukan risiko terjadinya DM dibandingkan IMT.Tujuan: untuk mengetahui hubungan LP dengan komposisi lemak tubuh dan IMT pada penderita DM tipe 2.Metode: Penelitian cross sectional pada penderita DM tipe 2 yang berobat ke RSUD Tugu Semarang bulan September 2018-Maret 2019, n= 80 orang, dengan consecutive sampling. Uji normalitas data dengan Kolmogorov-Smirnov, jika data normal dilanjutkan uji korelasi Pearson dan jika data tidak normal dilanjutkan uji korelasi Spearman?s rho. Hasil: LP memiliki hubungan signifikan, positif dan moderat dengan persentase total lemak tubuh (p <0,001, r = 0,451), hubungan signifikan, positif dan kuat dengan persentase lemak viseral (p <0,001, r= 0,693) dan lemak subkutan (p <0,001, r = 0,518). LP memiliki hubungan signifikan, positif dan sangat kuat dengan IMT (p <0,001, r = 0,801).Simpulan: LP memiliki hubungan positif kuat dengan lemak viseral, lemak subkutan dan IMT pada penderita DM tipe 2.Kata Kunci: lingkar pinggang, komposisi lemak tubuh, IMT, DM tipe 2

PENGARUH PENGGUNAAN BROQUET PADA PRESTASI MESIN SEPEDA MOTOR Arijanto, Arijanto; Nugroho, Heri
ROTASI VOLUME 13, NOMOR 1, JANUARI 2011
Publisher : Departemen Teknik Mesin, Fakultas Teknik, Universitas Diponegoro

Jumlah mobil di Indonesia telah mencapai 10 juta unit, bertambah 500 ribu unit per tahun dan sepeda motor lebih dari 25 juta unit dan bertambah 5 juta unit per tahun akan makin mencemari lingkungan serta memacu pemanasan global. Untuk mengurangi dampak emisi gas buang salah satu alat penghemat bahan bakar adalah katalisator Broquet. Katalis ini terbuat dari palladium campuran berbentuk kasa direndam dalam bahan bakar, sehingga oktan bahan bakar bertambah dan pembakaran menjadi lebih sempurna. Pengujian akan mengkaji efek penggunaan Broquet pada mesin sepeda motor Honda CS-1 125 cc terhadap perubahan performa mesin yang meliputi daya, torsi, konsumsi bahan bakar dan efisiensi. Dari hasil pengujian didapatkan torsi maksimal meningkat 18,8 % dari 11,44 Nm menjadi 13,60 Nm, setelah menggunakan broquet. Demikian juga terjadi peningkatan daya pengereman maksimal 22 % dari 0,92 kW menjadi 1,14 kW, selain itu juga diperoleh penghematan bahan bakar sebesar 13 % yang semula 1,14 liter/jam menjadi lebih hemat yaitu 1,01 liter/jam, Ditinjau dari prestasi mesin broquet layak digunakan sebagai penghemat bahan bakar alternatif bahkan dari hasil pengujian emisi gas buang penggunaan broquet juga lebih ramah lingkungan

Bone mineral density and osteoporosis related risk factors in type 2 diabetes mellitus Nugroho, Heri; Kurniawan, Rizal; Purnami, Cahya Tri
International Journal of Public Health Science (IJPHS) Vol 13, No 2: June 2024
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v13i2.23544

Diabetes mellitus negatively affects bone tissue and unfavourably impacts bone mineral density (BMD), therfore increasing the probability of fractures through pathological mechanisms. This study aimed to explore the factors associated with BMD and osteoporosis risk in individuals with a diagnosis of type 2 diabetes mellitus (T2DM). An investigation was undertaken involving 49 patients diagnosed with T2DM who fulfilled the specified criteria. These individuals underwent BMD assessment as part of a cross-sectional study. The analysis encompassed both univariate and bivariate approaches, utilizing the Chi-square test (X2) and binary logistic regression methods. A total of 30 participants (61%) have decreased BMD. Among the participants aged 60 years and above, 83.4% exhibited a decreased BMD status (osteopenia and osteoporosis), in contrast to the under 60 years age group, in which 40% displayed decreased BMD status. Older age (>60 years) is a risk factor for decreasing bone density onset of diabetes mellitus (DM) diagnosis, duration of DM, glycemic control, body mass index (BMI), use of thiazolidinediones (TZD) drugs, kidney function, were not associated with lower BMD in T2DM patients.

Effect of vitamin D3 supplementation on serum 25 (OH)D Levels, hand grip strength, blood sugar levels, and cognitive function in the elderly Probosari, Enny; Subagio, Hertanto Wahyu; Winarni, Tri Indah; Nugroho, Heri; Manikam, Nurul Ratna Mutu
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 13, No 1 (2024): December
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.13.1.79-87

ABSTRACTBackground: The aging process in the elderly can be caused by a decrease in vitamin D precursors and reduced Vitamin D levels due to impaired absorption of Vitamin D. Vitamin D plays a role in cognitive function, acts as an immunomodulator affecting blood glucose levels, promotes muscle atrophy, and affects the intranuclear VDR concentration and gene expression of VDR.Objectives: To determine the effect of vitamin D3 supplementation on Serum 25(OH)D levels, hand grip strength, blood sugar levels, and cognitive function in the elderly.Materials and Methods: This study used a quasi-experimental pre-posttest control group design with a total of 60 subjects included and divided into two groups. The treatment group received vitamin D3 at a dosage of 1000 IU/day for three months, while the control group was given a placebo. Blood serum levels were used to obtained serum 25(OH)D and blood sugar level. Hand grip strength values were measured by a hand grip dynamometer, and cognitive function was assessed using the Mini-Mental State Examination (MMSE) Questionnaire. The data was analyzed using the Wilcoxon test, and the bivariate analysis was performed using the Mann-Whitney test.Results: Most subjects were between 60 and 92 years old and had a vitamin D deficiency. Significant (P<0,05) differences were observed in serum 25(OH)D levels, blood sugar levels, and cognitive function following the intervention. The differences in serum 25(OH)D levels were 8,50±6,17, blood sugar levels were -21,68±25,88, and cognitive function was 2,23±3,05. Additionally, hand grip strength increased after the intervention (mean=0,42±4,66) but was not statistically significant (P=0,633).Conclusion: There is an improvement in cognitive function and a decrease in blood glucose levels, along with an increase in 25(OH)D levels after three months of vitamin D supplementation. However, hand grip strength did not significantly increase after supplementation.Keywords: Vitamin D3 Supplementation; serum 25(OH)D; hand grip strength; blood sugar level; cognitive function; elderly.

Correlation between haemoglobin, leukocytes, HbA1c, and albumin levels with diabetic foot ulcer severity: a cross-sectional study Sadyah, Nur Anna Chalimah; Nugroho, Heri; Putra, Agung; Riwanto, Ignatius
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 16, No 1 (2025): June 2025
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v16i1.41423

Diabetic foot ulcers (DFUs) represent a serious complication of diabetes mellitus, associated with significant morbidity and healthcare costs. The progression of DFUs is influenced by systemic and local factors, including haemoglobin levels, leukocyte count, glycated haemoglobin (HbA1c), and serum albumin. This study aims to explore the relationship between these clinical parameters and the severity of DFUs. We enrolled 62 patients with DFUs and classified ulcer severity as mild, moderate, or severe according to the Wagner classification system. Using Spearman’s rank correlation, we found significant associations: lower hemoglobin and albumin levels correlated with more severe ulcers (ρ = -0.34, p= 0.0065; ρ = -0.41, p = 0.00084, respectively), while higher HbA1c and leukocyte counts were associated with increased ulcer severity (ρ = 0.62, p = 0.000; ρ = 0.40, p = 0.0013, respectively). These findings suggest that hematologic and biochemical markers may serve as valuable indicators of DFU progression, potentially guiding clinical decision-making and improving patient outcomes. Further research is needed to elucidate the underlying mechanisms and evaluate targeted interventions for this high-risk population.

Pembentukan Identitas Budaya melalui Kepakaran Artistik dalam Film dan Televisi sebagai Sarana Representasi Sosial dalam Masyarakat Nugroho, Heri; Patrio, Andri Nur
Jurnal Riset Rumpun Seni, Desain dan Media Vol. 4 No. 2 (2025): Oktober: Jurnal Riset Rumpun Seni, Desain dan Media
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrsendem.v4i2.6727

Film and television play a central role in shaping and representing the cultural identity of society. Through artistic expertise manifested by directors, screenwriters, actors, cinematographers, and producers, cultural construction is presented not only as entertainment but also as a social discourse that reflects values, traditions, and the dynamics of collective identity. This study aims to analyze how artistic expertise contributes to constructing cultural identity representation through film and television mediums in Indonesia. The research methodology used is qualitative, employing content analysis and semiotics approaches on selected Indonesian films and TV series that highlight cultural aspects, such as Losmen Bu Broto and Gadis Kretek. These works were chosen because they feature rich local culture while reflecting the role of culture in the dynamics of Indonesian society. The findings indicate that artistic expertise plays a crucial role in constructing cultural representation, both through narrative, visual elements, music, and actors' performances. The representations produced not only affirm local and national identities but also reflect the process of cultural negotiation with global influences. This study underscores that film and television serve as strategic media for cultural diplomacy and the formation of collective identity awareness in Indonesian society. Through this process, these mediums contribute to the preservation of local culture amidst global cultural flows. The research highlights the importance of film and television as tools for maintaining and constructing cultural identity, where local traditions and values are both preserved and adapted to the changing global landscape.

Combined Sleeve Gastrectomy and Omentoplasty Improves Inflammation and Insulin Resistance in Obese Rats with Type II Diabetes Mellitus: A Randomized Controlled Trials Nugroho, Heri; Mughni, Abdul; Putranto, Indra Kusuma Adi; Prasetya, Anggoro Teguh; Novitasari, Vicky
The Indonesian Biomedical Journal Vol 16, No 3 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i3.3047

BACKGROUND: Diabetes mellitus (DM) is often associated with obesity, which can lead to chronic inflammation. Sleeve gastrectomy (SG) is a common treatment for obesity. Combining SG with omentoplasty, might help reducing inflammation in pancreatic beta cells. However, there is limited research regarding the combined effects of SG and omentoplasty in type 2 DM (T2DM). This study was conducted to fill this gap by evaluating the impact on body weight, insulin resistance, glucagon expression, and levels of interleukins (IL)-1, IL-6, and IL-10 in obese rats with type II DM.METHODS: An experimental study was conducted on 18 obese Wistar rats with DM that were randomized into: control, T1 (SG), and T2 (SG + omentoplasty). SG involved the surgical removal of a portion of the stomach to reduce its size, while omentoplasty utilized the omentum to target inflammation in pancreatic beta cells. Venous blood samples were taken from subjects one day before and ten days after the intervention to measure the biomedical parameters with various methods. Data was statistically analyzed using paired t-tests for pre-test and post-test differences, and Post Hoc tests or Mann-Whitney tests for hypothesis testing.RESULTS: All rats were confirmed to have obesity and DM according to the Lee index and blood glucose levels. T2 group exhibited a significant decrease in body weight, homeostatic model assessment of insulin resistance (HOMA-IR) values were lower, and glucagon expression, IL-1, IL-6, and IL-10 levels were significantly greater compared to both control and T1 groups.CONCLUSION: The combination of SG and omentoplasty significantly improves inflammation and insulin resistance in obese rats with T2DM.KEYWORDS: diabetes mellitus, sleeve gastrectomy, omentoplasty, inflammation, obesity

Lycopene Enhances the Beta Cell Capacity and Antihyperlipidemic Effects of Metformin on Type 2 Diabetic Rats Nugroho, Heri; Sianturi, Medina; Retnoningrum, Dwi; Susiloningsih, Neni
The Indonesian Biomedical Journal Vol 16, No 3 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i3.2989

BACKGROUND: Hyperglycemia causes dyslipidemia in type 2 diabetes mellitus (T2DM). Metformin monotherapy is known to be less effective at improving glycemic status, insulin function, and lipid profiles. Lycopene is a potential antioxidant and has been shown to be hypoglycemic and hypocholesterolemic. However, the effects lycopene and metformin combination are still up for debate. This study was conducted to determine the potential of lycopene in enhancing the ability of metformin to improve glycemic status, insulin resistance, beta cell capacity, and lipid profile of T2DM rats.METHODS: Thirty male Wistar rats were randomly divided into six groups: control (N), T2DM-untreated (D), T2DM + metformin (DM), T2DM + metformin + 10 mg/kgBW lycopene (DMLy-10), T2DM + metformin + 20 mg/kgBW lycopene (DMLy-20), and T2DM + metformin + 40 mg/kgBW lycopene (DMLy-40). The treatment was administered once daily through oral route and lasted for 28 days, before blood samples were collected. Fasting blood glucose (FBG) was assessed by oxidase-peroxidase method, fasting serum insulin and HbA1c were measured using enzyme-linked immunosorbent assay (ELISA), while lipid profile was determined using enzymatic methods. The homeostatic model assessment for insulin resistance (Homa-IR) as well as the homeostatic model evaluation of β-cell function (Homa-B) were then calculated.RESULTS: Fasting serum insulin levels increased significantly (p<10.05) in the DMLy-20 and DMLy-40 groups, but Homa-B or high-density lipoprotein (HDL) did not significantly increase. Additionally, the FBG, HbA1c, Homa-IR, total cholesterol, triglyceride, and low-density lipoprotein levels were not significantly decreased than in the group treated with metformin alone.CONCLUSION: Lycopene can enhance the ability of metformin to improve the glycemic status, insulin resistance, beta-cell capacity, and lipid profile of T2DM rats.KEYWORDS: dyslipidemia, Homa-B, insulin resistance, lycopene, metformin, type 2 diabetes mellitus

Co-Authors Abdul Mughni Agung Putra Andri Nur Patrio Arijanto Arijanto Cahya Tri Purnami Enny Probosari Etisa Adi Murbawani Hertanto Wahyu Subagio Ignatius Riwanto, Ignatius Lestariningsih Lestariningsih Maria Suryani Medina Sianturi Novitasari, Vicky Nur Anna Chalimah Sadyah Nurhasanah Nurhasanah Nurul Ratna Mutu Manikam Prasetya, Anggoro Teguh Putranto, Indra Kusuma Adi Retnoningrum, Dwi Rini, Sulistio Rizal Kurniawan Selamat Budijitno Siti Fatimah Muis Suharyo Hadisaputro Susiloningsih, Neni Tri Indah Winarni Widiastuti Samekto

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