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All Journal Jurnal Sains dan Kesehatan Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian
Anis Puji Rahayu
Universitas Muhammadiyah Bandung
Health Professions Medicine & Pharmacology Public Health

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Coronavirus-SARS-CoV-2: Biology and Problems in rRT-PCR Detection Maelita Ramdani Moeis; Anis Puji Rahayu; Nisa Ihsani; Wulan Pertiwi
Borneo Journal of Pharmacy Vol. 3 No. Special-1 (2020): Borneo Journal of Pharmacy: COVID-19
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v3iSpecial-1.1429

Abstract

Coronavirus disease 2019 (COVID-19) first appeared in China in December 2019 and was declared a pandemic by the World Health Organization. COVID-19 is caused by Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2), a new virus previously unknown to humans. Here we look at what is known about this virus, the main method for detecting the presence of this virus in a person who is used as a golden standard, and the problems that could arise in this detection method. Understanding the biology of the virus and the strengths and weaknesses of the detection method are important for patient management and for overcoming the pandemic.
AKTIVITAS ANTIBAKTERI DAUN TUBA LAUT (Derris trifoliata Lour) ASAL INDONESIA TERHADAP BAKTERI METHICILLIN RESISTANT Staphylococcus aureus ATCC BAA-44 Anis Puji Rahayu; Aghnia Dwijunnisa Zabir; Rokhimatul Maula; Tina Rostinawati
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.752

Abstract

Daun tuba laut (Derris trifoliata Lour.) banyak digunakan masyarakat pesisir pantai utara pulau Jawa sebagai tanaman herbal bermanfaat. Hal ini menarik perhatian banyak peneliti untuk menelaah kandungan senyawa dan aktivitas farmakologi yang dimiliki daun tersebut. Daun tuba laut memiliki aktivitas antibakteri terhadap 25 jenis bakteri patogen. Namun kajian aktvitasnya terhadap bakteri resisten yang salah satunya adalah Methicillin Resistant Staphylococcus aureus (MRSA) ATCC BAA-44 belum dilakukan. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri ekstrak metanol dan tiga jenis fraksi (air, etil asetat, n-heksan) dari daun tuba laut terhadap MRSA. Ekstraksi dilakukan melalui proses maserasi dan dilanjutkan dengan fraksinasi bertingkat. Skrining aktivitas antibakteri diawali menggunakan metode difusi padat untuk mengamati adanya diameter hambat. Penentuan Konsentrasi Hambat Minimum (KHM) dan Konsentrasi Bunuh Minimum (KBM) dilakukan melalui metode dilusi padat. Ekstrak metanol daun tuba laut menunjukkan adanya aktivitas antibakteri pada kosentrasi 50% (b/v). Sedangkan hasil skrining aktivitas antibakteri pada sampel fraksi teramati adanya zona inhibisi pada fraksi etil asetat dan tidak teramati pada fraksi air ataupun n-heksana. Nilai KHM dan KBM fraksi etil asetat daun tuba laut secara berturut-turut diperoleh sebesar 10 mg/ml dan 15 mg/ml. Kata kunci : aktivitas antibakteri; daun tuba laut; MRSA
Formulasi, Evaluasi, dan Uji Aktivitas in Vivo Kapsul Ekstrak Daun Pepaya California (Carica papaya L.) pada Model Zebrafish Adelia Putri Callysta; Feris Dzaky Ridwan Nafis; Anis Puji Rahayu
Jurnal Sains dan Kesehatan Vol. 10 No. 1 (2026): Juni : Jurnal Sains dan Kesehatan (JUSIKA)
Publisher : Universitas Muhamadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jusika.v10i1.1154

Abstract

California papaya leaves (Carica papaya L.) are known to contain various active compounds that have the potential to stimulate appetite and boost metabolism, making them a promising candidate for development as a pharmaceutical formulation. This study aims to design a capsule formulation of California papaya leaf extract with appropriate excipients and to evaluate its ability to increase body weight through preclinical testing using a zebrafish (Danio rerio). The extract was obtained via maceration with 96% ethanol and formulated into capsules using the wet granulation method in four variations (F0–F3). Physical evaluations included organoleptic properties, flowability, angle of repose, loss on drying, disintegration time, weight uniformity, and stability testing using the cycling test method. The results indicated that all formulas met the physical requirements, with disintegration times of 3–4 minutes and loss on drying <15%. Formula F2 exhibited the most optimal physical characteristics; however, stability testing revealed a decline in physical properties after extreme temperature treatment. Efficacy tests showed a significant increase in zebrafish weight (p < 0.05), with F3 yielding the best results. A high survival rate (≥80%) suggests the formulation is relatively safe. In conclusion, California papaya leaf extract capsules demonstrate significant potential as an agent to promote weight gain.
Co-Authors Adelia Putri Callysta Aghnia Dwijunnisa Zabir Feris Dzaky Ridwan Nafis Maelita Ramdani Moeis Nisa Ihsani Rokhimatul Maula Tina Rostinawati Wulan Pertiwi