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Prediksi Struktur 3D L-Asparaginase Bakteri Laut Vibrio sp. AND4 dengan Metode Homology Modelling Wulan Pertiwi; Luthfia Hastiani Muharram; Farhan Azhwin Maulana
Jurnal Sains Farmasi & Klinis Vol 9, No 2 (2022): J Sains Farm Klin 9(2), Agustus 2022
Publisher : Fakultas Farmasi Universitas Andalas

L-asparaginase merupakan enzim yang menghidrolisis L-asparagin menjadi L-aspartat dan ammonia yang dapat digunakan dalam terapi pengobatan Leukemia Limfoblastik Akut. Penentuan struktur 3D L-asparaginase dari berbagai sumber dapat memberikan informasi penting dalam memahami sifat dan fungsi biokimia L-asparaginase di level molekuler untuk penelusuran L-asparaginase alternatif sebagai protein teurapetik. Tujuan penelitian ini adalah memprediksi struktur 3D enzim L-asparaginase II dari bakteri laut Vibrio sp. AND4 dengan E.coli L-asparaginase II mutant (T12V) in complex with L-Asn at pH 7.0 [Escherichia coli K-12] (PDB ID: 6PA9) sebagai templat struktur, menggunakan metode pemodelan homologi dengan program SWISS-MODEL. Penelitian ini menghasilkan model struktur 3D dengan Sequence identity 70,55%, memiliki nilai QMEANDisCo 0,86±0,05 dan nilai GMQE sebesar 0,86. Terdapat 93,1% residu berada di daerah the most favored regions dan 0,3% residu berada di daerah disallowed regions pada Ramachandran plot, dengan G-Factors sebesar -0.08 yang memenuhi syarat-syarat kualitas struktur ideal.

Coronavirus-SARS-CoV-2: Biology and Problems in rRT-PCR Detection Maelita Ramdani Moeis; Anis Puji Rahayu; Nisa Ihsani; Wulan Pertiwi
Borneo Journal of Pharmacy Vol. 3 No. Special-1 (2020): Borneo Journal of Pharmacy: COVID-19
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v3iSpecial-1.1429

Coronavirus disease 2019 (COVID-19) first appeared in China in December 2019 and was declared a pandemic by the World Health Organization. COVID-19 is caused by Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2), a new virus previously unknown to humans. Here we look at what is known about this virus, the main method for detecting the presence of this virus in a person who is used as a golden standard, and the problems that could arise in this detection method. Understanding the biology of the virus and the strengths and weaknesses of the detection method are important for patient management and for overcoming the pandemic.

The DIGITALISASI DESA MELALUI PENDEKATAN SIMBOLIS DAN SUBSTANTIF DI DESA MARGAASIH, KECAMATAN MARGAASIH Haris Wahyudin; M Fadhlan Akhbari Wildhan; Muhamad Kamil Mauludin; Muhammad Luthfi Hijari; Nur Fadilah Febriani; Regita Aryaputri Lesmana; Sahwa Alfitri; Siti Rahim Mardhatillah; Syazidah Tulfa Tehupelasury; Tirani Salmaini Zahirah; Wulan Pertiwi
BAKTIMU : Jurnal Pengabdian Kepada Masyarakat Vol 3 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/bm.v3i3.958

Desa Margaasih, Kecamatan Margaasih masih terbilang minim dalam ketersediaan informasi terkait desa dari berbagai segi. Secara individu, kapabilitas literasi digital masyarakat desa pun terbilang minim mengingat potensi digital hanya dimanfaatkan dalam ruang-ruang interaksi dan komunikasi. Pelaksanaan Digitalisasi Desa ditujukan untuk mengentaskan permasalahan ketersedian informasi digital serta meningkatkan literasi digital masyarakat melalui pendekatan simbolis dan substantif. Proses pelaksanaan terdiri dari tiga tahap; Perencanaan, Pengukuran dan Pelaksanaan dengan berorientasi pada hasil yang bersifat simbolis dan substantif melalui metode observasi di lapangan secara langsung. Pelaksanaan digitalisasi desa menghasilkan bentuk-bentuk simbolis dan substantif yang terdiri dari website, film dokumenter, poster QR dan poster informasi serta tambahan kegiatan seminar dan pelatihan pada bentuk hasil dari dimensi substansi. Pada hasil pelaksanaannya masih diperlukan pengembangan-pengembangan secara kuantitas maupun kualitas. Kata Kunci: Digitalisasi; Simbolis; Substantif, Literasi, Desa

The DIGITALISASI DESA MELALUI PENDEKATAN SIMBOLIS DAN SUBSTANTIF DI DESA MARGAASIH, KECAMATAN MARGAASIH Haris Wahyudin; M Fadhlan Akhbari Wildhan; Muhamad Kamil Mauludin; Muhammad Luthfi Hijari; Nur Fadilah Febriani; Regita Aryaputri Lesmana; Sahwa Alfitri; Siti Rahim Mardhatillah; Syazidah Tulfa Tehupelasury; Tirani Salmaini Zahirah; Wulan Pertiwi
BAKTIMU : Jurnal Pengabdian Kepada Masyarakat Vol 3 No 3 (2023)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/bm.v3i3.958

Desa Margaasih, Kecamatan Margaasih masih terbilang minim dalam ketersediaan informasi terkait desa dari berbagai segi. Secara individu, kapabilitas literasi digital masyarakat desa pun terbilang minim mengingat potensi digital hanya dimanfaatkan dalam ruang-ruang interaksi dan komunikasi. Pelaksanaan Digitalisasi Desa ditujukan untuk mengentaskan permasalahan ketersedian informasi digital serta meningkatkan literasi digital masyarakat melalui pendekatan simbolis dan substantif. Proses pelaksanaan terdiri dari tiga tahap; Perencanaan, Pengukuran dan Pelaksanaan dengan berorientasi pada hasil yang bersifat simbolis dan substantif melalui metode observasi di lapangan secara langsung. Pelaksanaan digitalisasi desa menghasilkan bentuk-bentuk simbolis dan substantif yang terdiri dari website, film dokumenter, poster QR dan poster informasi serta tambahan kegiatan seminar dan pelatihan pada bentuk hasil dari dimensi substansi. Pada hasil pelaksanaannya masih diperlukan pengembangan-pengembangan secara kuantitas maupun kualitas. Kata Kunci: Digitalisasi; Simbolis; Substantif, Literasi, Desa

Review: Peran Protein Virus dalam Host Immune System Evasion Nurhaifa Azzahra; Nazif Muhammad; Wulan Pertiwi
Jurnal Biodiversitas dan Bioteknologi Vol 2 No 2 (2025): Biodiverse: Jurnal Biodiversitas dan Bioteknologi
Publisher : Jurnal Biodiversitas dan Bioteknologi

Show Abstract | Download Original | Original Source | Check in Google Scholar

The human body has an immune system that functions to protect the body from pathogens such as bacteria and viruses. This system consists of two types of immunity: non-specific immunity (innate immunity) and specific immunity (adaptive immunity). Non-specific immunity acts quickly using various cells and molecules to combat pathogens, while specific immunity takes longer but is more effective and has the ability to remember pathogens for a faster response in the future. Despite this, many viruses have developed mechanisms to evade detection and elimination by the immune system, known as immune evasion. This evasion is carried out in various ways, including modifications of viral proteins that disrupt immune pathways, such as antigen presentation, interferon signaling, and immune cell functions. This literature review aims to identify the various strategies used by viruses to evade the immune system. The method used is a literature search from various scientific journals such as PubMed, Wiley, and Elsevier. The analysis results show that viruses can avoid PRR detection, inhibit JAK-STAT signaling, and regulate autophagy to survive and replicate within the host body. This study provides an in-depth understanding of the immune evasion mechanisms by viruses, which are a major challenge in the treatment and prevention of infectious diseases. A deep understanding of these immune evasion mechanisms in crucial for developing more effective strategies to fight viral immune evasion, thereby enhancing the effectiveness of therapies and vaccines in the treatment and prevention of infectious diseases

Peran Virus Onkolitik dalam Terapi Kanker: Tinjauan Literatur Tiara Zahira; Mahesa Dhiyaa Alkhairan; Rica Handayati; Wulan Pertiwi
Jurnal Biodiversitas dan Bioteknologi Vol 2 No 2 (2025): Biodiverse: Jurnal Biodiversitas dan Bioteknologi
Publisher : Jurnal Biodiversitas dan Bioteknologi

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Cancer is one of the leading causes of death in the world and a major challenge in the medical world. This disease is caused by uncontrolled cell growth and can damage healthy tissue. Conventional therapy still has limitations, so new approaches are needed such as oncolytic virus-based therapy. This study aims to present a review of the use of oncolytic viruses in cancer therapy, including the mechanism of action, effectiveness, and challenges faced. The method used is an online literature review with a focus on various aspects of oncolytic viruses. The results show that oncolytic viruses can destroy cancer cells in a specific way, while triggering the body's immune response. In addition, this therapy shows better effectiveness when combined with chemotherapy. The use of oncolytic viruses as cancer therapy offers promising potential, although there are still challenges in terms of virus spread and patient response. Further development is needed to maximize the effectiveness of this therapy.

Strategi Pencegahan Influenza Terhadap Resistensi dan Efektivitas Antiviral : Kajian Literatur Aulia Putri Salsabila; Neva Afifah Putri Suharja; Nurul Fadhillah; Wulan Pertiwi
Jurnal Biodiversitas dan Bioteknologi Vol 2 No 2 (2025): Biodiverse: Jurnal Biodiversitas dan Bioteknologi
Publisher : Jurnal Biodiversitas dan Bioteknologi

Show Abstract | Download Original | Original Source | Check in Google Scholar

Influenza is a viral infection that can cause serious complications and spread rapidly. Antivirals such as oseltamivir, zanamivir, peramivir and baloxavir are effective at reducing the duration of illness if given within the first 48 hours. However, viral mutations can lead to resistance to antivirals, decreasing the effectiveness of treatment. This review analyzes antiviral resistance and effectiveness based on a literature review from various sources. Results show that resistance to oseltamivir and amantadine is a major challenge, and antiviral effectiveness is affected by the timing of administration, patient condition, and viral mutations. Several strategies, including antiviral combinations, new drug development, herbal plants, and vaccination, were developed to overcome resistance, but none have been fully effective. Monitoring viral resistance and developing adaptive treatment strategies are needed to improve influenza control.

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