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All Journal Medical Journal of Indonesia Majalah Patologi Indonesia Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Makara Journal of Health Research
Meilania Saraswati
Faculty of Medicine Universitas Indonesia/ Cipto Mangunkusumo Hospital, Jakarta
Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health

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Analysis Expression of ZIP1 and Caspase-3 Protein in Adenocarsinoma of the Prostate Septiawan, Aditya D; Kodariah, Ria; Saraswati, Meilania
Makara Journal of Health Research Vol. 20, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: Carcinogenesis of adenocarcinoma of the prostate occurs due to dysregulation of zinc level within the cells. Intracellular zinc molecules influx is regulated by a transporter protein ZIP1, whose non-presence is predicted to inhibit apoptosis, thus leads to the development of prostate adenocarcinoma. Methods: This study was aimed to analyse the correlation of ZIP1 and Caspase-3 expression in prostate adenocarcinoma on its grading as represented by Gleason Score. This was a cross-sectional, retrospective analytical study on 31 Formalin-fixed, paraffin-embedded tissue that meets inclusion criteria. The specimen was stained using the immune-histochemistry technique for ZIP1 and Caspase-3. Protein expression of each case was counted using ImageJ analysis. Gleason score was acquired as secondary data from the cases' reports. The correlation of their expression with respect to Gleason score was analysed with Pearson's correlation using SPSS 11.5. Results: Mean expression level of ZIP1 and Caspase-3 in prostate adenocarcinoma were 35% and 33%, respectively. There was a significantly positive correlation between ZIP1 and Caspase-3 expression (r = 0.379; p = 0.018). However, their correlation was stronger in intermediate-grade group (r = 0.73; p = 0.01) and the correlation was much weaker in high-grade group (r = 0.04; p = 0.48). Conclusions: There was a positive correlation between ZIP1 and Caspase-3 expression in prostate adenocarcinoma.
Pemanfaatan Diskusi Berdasarkan Kasus Sebagai Ujian Formatif Dalam Program Pendidikan Dokter Spesialis Patologi Anatomik Fakultas Kedokteran Universitas Indonesia Saraswati, Meilania; Simadibrata, Marcellus; Mustika, Rita
Majalah Kedokteran Indonesia Vol 70 No 4 (2020): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.70.4-2020-234

Abstract

Background: Postgraduate program for Anatomical Pathology Specialist in Faculty of Medicine Universitas Indonesia use competence-/outcome-based curriculum approach. However, until now, the program has not yet adopted a structured, recorded, formative workplace-based assessment, for example, case-based discussion.Method: This was an explorative qualitative research regarding the use of formative assessment case-based discussion during educational process in postgraduate program for anatomical pathology specialist in FMUI. Interview and focused group discussion to the program manager, teaching staff and the residents were performed. Teaching staff was asked to perform three times case-based discussion (CbD) formative assessment toward the resident. Post-intervention, interview and focused group discussion to the staf and resident were conducted. Result: The staffs and residents of Anatomical Pathology Specialist Program of FMUI showed positive response toward CbD formative assessment. CbD formative assessment enabled deeper discussion between the staffs and residents regarding establishing diagnosis. The staffs were able to monitor the residents’ learning process and giving specific feedback toward the residents. The residents were able to learn about a case in a more comprehensive way and acquiring specific feedback and summative assessment simulation.Conclusion: CbD formative assessment is useful in the process of acquiring competence in diagnosis in a postgraduate education that uses competence- or outcome-based curricula.
Profil Klinikopatologik Kasus Adenokarsinoma Prostat di RSCM Tahun 2010-2019 dengan Tinjauan Khusus Biopsi Robotik Rizky Prasetya, Gusti; Saraswati, Meilania; Rizal AH. Hamid, Agus; BRE. Matondang, Sahat
Majalah Patologi Indonesia Vol 31. No. 3, September 2022
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v31i3.512

Abstract

BackgroundProstate adenocarcinoma is second most common malignancy in men and fourth leading death cause from malignancy worldwide. Prostate biopsy is the gold standard for diagnosing this disease. However, the difficulty of sampling is a weakness in this procedure. In Cipto Mangunkusumo hospital, biopsy technology is now available with robotic techniques for biopsy sampling, which is expected to increase prostate biopsy accuracy. This study was to determine prostate adenocarcinoma case profile in the Department of Pathology Anatomic Cipto Mangunkusumo Hospital for 10 years and to examine differences in sampling of biopsy preparations with robotic and non-robotic techniques. MethodsThis study was an exploratory descriptive study with cross-sectional design to determine prostate adenocarcinoma case profile in the Department of Anatomic Pathology FKUI-RSCM for 10 years. The data obtained between the Gleason score of prostate biopsy preparations and surgery. Robotic prostate biopsy results were compared with prostate imaging reporting and data system (PIRADS) score. ResultsThe mean age of the patients was 67 years old and several patients were aged <50 years old. Many poor differentiation cases were found. It appears that there is a relationship between WHO/ISUP degree and perineural invasion. In 14 patients who underwent histopathological examination more than once, it was found that 9 patients had the same WHO/ISUP degree and 5 patients had a changed WHO/ISUP degree. There are several discrepancies in PIRADS score and histopathological findings from 21 robotic preparations examined. ConclusionThe mean age of patients fit to theory of generalized prostate adenocarcinoma. Many cases of poor differentiation were found, possibly related to RSCM as a national referral center. The repeated sample examination results are similar to the results of other studies. Robotic method biopsy gives the sense of more comprehensive sampling in comparison to non-robotic method.
SOX2 expression in the primary tumor of castration-naive metastatic prostate adenocarcinoma in association with metastasis extent Saraswati, Meilania; Kekalih, Aria; Lisnawati; Rahadiani, Nur; Asmarinah; Hernowo, Bethy Suryawathy; Hamid, Agus Rizal Ardy Hariandy; Mochtar, Chaidir Arif
Medical Journal of Indonesia Online First
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.247588

Abstract

BACKGROUND Poor prognosis in patients with metastatic prostate adenocarcinoma (mPCa) may be due to the expression of stem cell-related genes. This study aimed to demonstrate the association between the expression of cancer stem cell markers and metastasis in patients with castration-naive mPCa. METHODS This cross-sectional, analytical study investigated a formalin-fixed paraffin-embedded prostate specimens from patients diagnosed in Cipto Mangunkusumo Hospital. Patients aged ≥50 years old were grouped based on the extent of metastases (high-volume disease [HVD] and low-volume disease [LVD]). In each case, immunohistochemical staining for CD133, CD44, SOX2, and androgen receptor was performed and analyzed using H-score. All data were recorded and analyzed using SPSS software version 20.0. RESULTS A total of 61 patients were recruited from 2020 to 2023 and divided into the HVD (n = 38) and LVD (n = 23) groups, with a mean age of 67.9 years. 45 of the patients had International Society of Urological Pathology (ISUP) grade 5 disease, while 16 of them had grade <5. A significant difference of ISUP grade and PSA serum level was observed in the HVD versus LVD group (p = 0.017 and <0.001, respectively). Additionally, a significant association was found between SOX2 expression and metastatic extent. CONCLUSIONS The LVD group showed higher SOX2 expression in the primary tumor compared to the HVD group. Different SOX2 expressions in various sites and stages may be due to the cancer cells’ systemic network.
Co-Authors Agus Rizal Ardy Hariandy Hamid, Agus Rizal Ardy Hariandy Aida Lydia Aria Kekalih Asmarinah Bethy Suryawathy Hernowo BRE. Matondang, Sahat Chaidir Arif Mochtar Dharmeizar Dharmeizar Lisnawati Marcellus Simadibrata Mustika, Rita Rahadiani, Nur Ria Kodariah Rizal AH. Hamid, Agus Rizky Prasetya, Gusti Saraswati, Mita Hafsah Septiawan, Aditya D Siti Setiati