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All Journal Medical Journal of Indonesia Majalah Kedokteran Andalas Majalah Patologi Indonesia

Nur Rahadiani

Department Of Anatomical Pathology, Faculty Of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta

Author-ID : 954373

Health Professions Medicine & Pharmacology Public Health

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The low prevalence of colonic serrated adenocarcinoma with high KRAS mutational status at Cipto Mangunkusumo Hospital, Indonesia Rahadiani, Nur; Handjari, Diah R.; Stephanie, Marini; Krisnuhoni, Ening
Medical Journal of Indonesia Vol 27, No 3 (2018): September
Publisher : Faculty of Medicine Universitas Indonesia

Background: Serrated adenocarcinoma (SA), a subtype of colorectal carcinoma, and the KRAS mutation, a strong marker for the patient’s response to anti-epidermal growth factor receptor therapy, have a clinical importance because of its progressive nature and tendency for chemoresistance. The purposes of this study were to (1) determine the prevalence of SA, (2) evaluate the histomorphological characteristics of SA and classical adenocarcinoma based on its prognostic factors, (3) determine the prevalence of the KRAS mutation in SA cases, and (4) identify the main characteristics of SA cases and classical adenocarcinoma with a KRAS mutation.Methods: This study was conducted by reviewing hematoxylin-eosin-stained slides of colorectal carcinoma (CRC) cases from January 2013 to July 2015 at the Department of Anatomical Pathology Cipto Mangunkusumo General Hospital. The final diagnosis of SA was based on the Tuppurainen et al criteria and the KRAS mutation was evaluated using real-time polymerase chain reaction.Results: Among the 117 adenocarcinoma cases, there were 41 unequivocal SA, 11 equivocal SA, and 65 classical adenocarcinoma. The prevalence rates of unequivocal and equivocal SA among all CRC cases were 7.7% and 2.1%, respectively. There were 11 (28.2%) cases of wild-type KRAS and 28 (71.7%) cases of mutated KRAS among all unequivocal SA cases. Tumor budding (TB) was the predominant prognostic factor.Conclusion: The prevalence of SA among all CRC cases was 7.7%. The KRAS mutation was found in almost three-quarters of all SA cases.

Perbandingan Akurasi Pemeriksaan Imunohistokimia SOX10 dengan DOG1 dalam Mendiagnosis Karsinoma Sel Asinik Kelenjar Liur pada Sediaan FFPE Ricky Handika; Ika Dhuhani; Nur Rahadiani
Majalah Patologi Indonesia Vol 29 No 1 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundMorphological diversity is a challenge in establishing diagnosis of malignant tumor originated from salivary gland, especially Aciniccell carcinoma (ACC). Immunohistochemical (IHC) staining using DOG1 is often used to help diagnosis of ACC. Lately, IHC SOX10has been reported to have almost the same accuracy to DOG1 staining. This evidence-based case report aims to determine theaccuracy of SOX10 to DOG1 immunohistocheinstry staining in establishing a diagnosis of ACC.MethodsLiterature searches were carried out on the Pubmed, Clinical key, Proquest, ScienceDirect, Scopus, SpringerLink and Wileydatabases. Two journals were relevant to the clinical scenario, then a critical review is carried out using the Diagnostic StudyAppraisal Worksheet from the Center for Evidence-based Medicine, University of Oxford, 2010.ResultsThe accuracy of SOX10 in diagnosing ACC was slightly better than DOG1, with sensitivity reaching 100% and specificity reaching87.76%. The sensitivity of SOX10 and DOG1 is the same, but SOX10 is more specific, and positive predictive value is also betterthan DOG1.ConclusionThe accuracy of SOX10 is better than DOG1 in diagnosing ACC of salivary gland. However, the intensity of SOX10 staining tends tobe rather low compared to DOG1. Therefore, further research is still needed to recommend SOX10 staining in daily practice.

Ketepatan Pemeriksaan Imunohistokimia CK19 Dibandingkan dengan PDX-1 pada Tumor Pankreas dan Anak Sebarnya Bayu Perkasa Rosari; Michelle Linggodigdo; Yan Cahya Wijaya; Marini Stephanie; Nur Rahadiani
Majalah Patologi Indonesia Vol 30 No 3 (2021): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundMetastatic adenocarcinoma of unknown origin remains a serious problem in oncology. Pancreatic cancer is often diagnosed when ithas already metastasized. Therefore immunohistochemistry (IHC) examination for detecting metastases of pancreatic origin is veryimportant IHC marker of Pancreatic duodenal homeobox-1 (PDX-1) has a good accuracy for detecting metastases of pancreaticorigin, however it is not readily available in many centers in Indonesia. Instead, IHC marker that is often being used is CK19. Thismarker is not specific, because it is also expressed by gastrointestinal and hepatobilliary tumors. This evidence-based case reportaims to determine the accuracy of CK19 compared with PDX-1 IHC for detecting pancreatic tumor and its metastases.MethodsLiterature searches were conducted on Pubmed/MEDLINE®, Scopus®, Cochrane®databases. Four articles about PDX-1 and 5 articlesabout CK19 that are relevant were found. Those articles were critically appraised.ResultsAll articles are considered valid, as they fulfilled the important criteria for journal validity. A study of CK19 IHC found that this markerhas 100% sensitivity and 6% specificity for diagnosing liver metastases from well-differentiated pancreatic ductal adenocarcinoma.Studies of PDX-1 IHC have different results; a study found that 27 out of 67 were PDX-1 positive in metastases of pancreaticadenocarcinoma origin, while another study found that PDX-1 has 72% sensitivity and 93% specificity for pancreatic neuroendocrinetumor, with 100% sensitivity and 75% specificity for pancreatic neuroendocrine tumor metastases.ConclusionCK19 IHC is highly sensitive for detecting adenocarcinoma metastases of pancreatic origin, thus it can be utilized as a screening test.However, CK19 IHC specificity for detecting adenocarcinoma metastases of pancreatic origin is low compared to PDX-1 IHC

Akurasi Pemeriksaan Polymerase Chain Reaction Menggunakan Primer IS6110 dan MPB64 untuk Mendeteksi Mycobacterium tuberculosis pada Spesimen Formalin-Fixed Paraffin-Embedded Timotius Benedict Djitro; Faramitha Nur Izzaty; Nur Rahadiani
Majalah Patologi Indonesia Vol 28 No 3 (2019): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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ABSTRAKLatar belakangTantangan yang dihadapi dalam mengontrol penyakit tuberculosis (TB) adalah ketersediaan alat diagnostikyang cepat dan tepat. Pemeriksaan baku emas untuk diagnosis TB saat ini adalah kultur bakteri tahan asam,tetapi metode ini membutuhkan waktu yang lama dan tidak dapat digunakan pada jaringan yang telah difiksasidengan formalin. Pemeriksaan PCR memliki sensitivitas dan spesifisitas yang tinggi, membutuhkan waktu yanglebih singkat dibanding kultur, serta dapat digunakan pada jaringan yang telah difiksasi dengan formalin.Laporan ini bertujuan mengetahui akurasi pemeriksaan PCR menggunakan primer IS6110 dan MPB64 untukmendeteksi M.tuberculosis pada spesimen FFPE (formalin-fixed paraffin-embedded).MetodeDilakukan pencarian literatur pada basis data Pubmed, Scopus, Proquest, Springer Link dan Cochrane.Terdapat dua jurnal yang relevan dengan kasus, lalu dilakukan telaah kritis menggunakan Diagnostic StudyAppraisal Worksheet dari Centre for Evidence-based Medicine, University of Oxford, 2010.HasilDari kedua jurnal, akurasi PCR dengan primer IS6110 dan MPB64 saat ini masih kurang baik, Sensitivitasberkisar antara 45,5-88,9%, spesifisitas antara 88,1-100%. Rentang nilai sensitivitas yang luas ini kemungkinandisebabkan oleh volume dan proses embedding jaringan yang dapat menyebabkan kerusakan integritas DNAM.tuberculosis.KesimpulanPemeriksaan PCR dengan primer IS6110 dan MPB64 dapat digunakan sebagai konfirmasi pada spesimenFFPE karena nilai spesifisitas yang tinggi dari pemeriksaan ini. Nilai sensitivitas yang bervariasi berisikomenghasilkan negatif palsu apabila tidak ada pemeriksaan lain yang digunakan bersama dengan PCR padaspesimen FFPE.

Perbedaan Profil Histomorfologik Jaringan Hati Resipien dan Donor Pascatransplantasi Hati Anak antara Kelompok Pasien Rejeksi dan Tidak Rejeksi di Departemen Patologi Anatomik FKUI/RSCM Periode 2010-2019 Alif Gilang Perkasa; Marini Stephanie; Nur Rahadiani; Diah Rini Handjari; Ening Krisnuhoni; Hanifah Oswari
Majalah Patologi Indonesia Vol 31 No 1 (2022): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundLiver rejection is an immune system response of recipient in which attacking the antigen originating from a donor that can causedamage to the transplanted organ. Although the prevalence of liver rejection has decreased due to the use of immunosuppressivedrugs, it is estimated that 20-40% of recipients still experience rejection and are at risk of re-transplantation and even death. Thisstudy aims to investigating histomorphological characteristics that can play a role as risk factors for rejection by assessing thedifferences in histomorphological characteristics before transplantation between recipient groups with rejection and non-rejection inpediatric liver transplant recipients in the Department of Anatomical Pathology, Faculty of Medicine, University of Indonesia, Dr.Cipto Mangunkusumo (PA-FKUI/RSCM)MethodsThis study was an analytical study with a cross sectional design, using secondary data from the archives of the Department ofAnatomical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo 2010-2019. The clinical andhistopathologic data obtained were analyzed using comparative statistical tests.ResultsRejection were found in 25% of recipients. Rejection were more common in the group of recipients aged >1 (75%), male (58%),cirrhosis 4C (92%) and mild portal inflammation (56%). Rejection were more common in the group of donor with male (66%) andsteatosis ≤10% (92%). There were no significant differences in the histomorphological profiles of recipients and donors with orwithout rejection.ConclusionThe histomorphologic profiles of both recipients and donors were known to be descriptively associated with complications of posttransplant liver rejection. However, in terms of analysis, there was not any significant differences

Ekspresi HER2/neu(c-ErbB2) pada Kanker Kolorektal Nita Afriani; Ening Krisnuhoni; Nur Rahadiani
Majalah Kedokteran Andalas Vol 37 (2014): Supplement 2 | Published in December 2014
Publisher : Faculty of Medicine, Universitas Andalas

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Kanker kolorektal merupakan keganasan pada kolon dan rektum, penyebab morbiditas danmortalitas ketiga terbanyak diantara keganasan lainnya. Penelitian ekspresi HER2 pada kankerkolorektal memiliki rentang yang cukup jauh yaitu 0-83% dan belum pernah dipublikasi dilndonesia. Penelitian ini bertujuan untuk menilai ekspresi HER2 pada kanker kolorektal. Studicross-secfiona/ dilakukan terhadap 51 sediaan blok parafin kanker kolorektal rentang tahunJanuari 2011-Desember 2012 di Departemen Patologi Anatorni RS Cipto MangunkusumoJakarta. Penilaian karakteristik sampel diambil dari rekam medis dan penilaian histopatologidari sediaan HE pasien kanker kolorektal. Pulasan imunohistokimia HER2 menggunakanantibodipoliklonalantiHER2(DAKO). Rata-rata usia penderita adalah 57.8t13.54tahun,58.8%penderita adalah laki-laki dan 41.2o/o perempuan. Semua sediaan adalah adenokarsinomakolorektal. Ekspresi HER2 positif ditemukan sebanyak 5(9.8%) kasus.AbstractColorectal cancer is a neoplasia of colon and rectum ,and also the 3rd leading cause ofmorbidity and mortality among men and women in the world. HER2 expression has controversialresults ranging from 0-83% and never been pubiished in lndonesia. This research aims tostudy HER2 expression in colorectal cancer. Cross-sectional study was conducted in 51 casesof colorectal cancer from January 2011 until December 2012 in Pathology Department ofCipto Mangunkusumo Hospital. Patient characteristic was reviewed from medical record andhistopathologic was evaluated from HE slides. lmunohistochemistry staining used anti HER2polyclonal antibody frorn DAKO. Mean age was 57.8113.54 years, 58.8% were males and41.2o4 were females. Positive HER2 was 5 cases (9.8%).

Co-Authors Alif Gilang Perkasa Bayu Perkasa Rosari Diah Rini Handjari Diah Rini Handjari Ening Krisnuhoni Faramitha Nur Izzaty Handjari, Diah R. Hanifah Oswari Ika Dhuhani Marini Stephanie Michelle Linggodigdo Nita Afriani Ricky Handika Sufangga, Fili Timotius Benedict Djitro Yan Cahya Wijaya

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