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All Journal JURNAL ILMIAH PENDIDIKAN FISIKA AL BIRUNI Jurnal Fisika FLUX International Journal of Applied Mathematics, Sciences, and Technology for National Defense Jurnal Penelitian Pendidikan
Yohannes Sardjono
Badan Tenaga Nuklir Nasional Pusat Sains dan Teknologi Akselerator
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Earth & Planetary Sciences Education Electrical & Electronics Engineering Materials Science & Nanotechnology Mathematics Physics

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Studi Awal Pengaruh Pemberian Asam Boron dan Penembakan Neutron terhadap cell fibroblast dan cell lineKanker Payudara Maslebu, Giner; Muninggar, Jodelin; S. Rondonuwu, Ferdy; Trihandaru, Suryasatriya; Widarto, Widarto; Sardjono, Yohannes
Jurnal Fisika FLUX Vol 14, No 2 (2017): Jurnal Fisika FLUX Edisi Agustus 2017
Publisher : Lambung Mangkurat University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/flux.v14i2.4191

Abstract

Kanker merupakan salah satu penyakit mematikan yang mendapatkan perhatian serius oleh peneliti dan praktisi di bidang kesehatan. Penyakit kanker adalah penyakit yang timbul akibat pertumbuhan tidak normal sel jaringan tubuh yang berubah menjadi sel kanker.Dari berbagai jenis kanker, kasus yang paling banyak terjadi pada kaum perempuan adalah kanker payudara. Teknik pengobatan kanker terus dikembangkan sehingga mampu secara selektif membunuh target sel kanker (cell targeting) dan memberikan efek yang minimal bagi sel sehat di sekitar target. Salah satu teknik pengobatan yang menjanjikan adalah Boron Neutron Captured Teraphy (BNCT). Dalam penelitian ini, sel fibroblast dan sel kanker payudara T47D dipanen pada sumuran setelah diinkubasi selama 16 jam, kemudian diberikan perlakuan  asam boron dengan dosis asam boron berjenjang 100 µM, 200 µM, 400 µM.Penembakan neutron diberikan dengan flux sebesar 1010 neutron/cm2s mengggunakan sumber neutron pada fasilitas reaktor Kartini PSTA-Batan terhadap kultur selselama 30 menit. Pada sel fibroblast tingkat kematian sel berkisar antara 2,5-21,212 % setelah pemberian asam Boron dan meningkat menjadi 24,242-71,424 % setelah penembakan neutron. Pada sel kanker payudara T47D tingkat kematian sel berkisar antara 26,761-48,76 % setelah pemberian asam Boron dan meningkat menjadi 36,585-56,25 % setelah penembakan neutron. Hasil penelitian ini menunjukkan ada pengaruh pemberian asam Boron dan penembakan Neutron terhadap tingkat kematian sel.
Investigation on electron contamination of LINAC at different operating voltages using particle heavy ion transport code system (PHITS) Bilalodin, Bilalodin; Haryadi, Aris; Sardjono, Yohannes; Kasesaz, Yaser
Jurnal Ilmiah Pendidikan Fisika Al-Biruni Vol 11 No 1 (2022): Jurnal Ilmiah Pendidikan Fisika Al-Biruni
Publisher : Universitas Islam Negeri Raden Intan Lampung, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24042/jipfalbiruni.v11i1.11929

Abstract

Research has been carried out to investigate the occurrence of secondary electron contamination in a linear accelerator (LINAC) machine. The research was conducted in a simulation using a Monte Carlo-based simulator, namely Particle and Heavy Ions Transport code System (PHITS). The simulation of the occurrence of secondary electron contamination was carried out based on the model of the LINAC Electa head that is operated at voltages of 6, 8, 10, 15, 18, and 25 MV, using a field area of 10 X 10 cm and SSD 100 cm. The simulation results show that electron contamination occurs due to the interaction of X-ray photons with the components of the LINAC head, namely the primary collimator, flattening filter, and secondary collimator. The secondary electron contaminants generated by the LINAC head components spread through the water phantom. The higher the operating voltage, the higher the secondary electron flux produced. The secondary electron contamination dose calculated in the water phantom shows that the higher the LINAC voltage, the higher is the dose received in the phantom.
Shielding innovation for health security: A PHITS-based optimization of Portland material for proton therapy Suyanto, Damar Adhiwidya; Oktaviana, Aditya Tri; Syväjärvi, Mikael; Sardjono, Yohannes; Wijaya, Gede Sustresna; Triatmoko, Isman Mulyadi
International Journal of Applied Mathematics, Sciences, and Technology for National Defense Vol 3, No 2 (2025): International Journal of Applied Mathematics, Sciences, and Technology for Natio
Publisher : FoundAE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58524/app.sci.def.v3i2.841

Abstract

Proton therapy is an advanced treatment method for cancer that uses protons to irradiate tumors with high precision. However, the high energy of protons requires effective shielding to protect the surrounding environment and personnel from radiation exposure. In this research, the radiation shielding performance of Portland material was evaluated using the PHITS version 3.351 simulation software. The study focuses on assessing the attenuation of radiation within the cyclotron room under various operational conditions. The effectiveness of radiation shielding made from Portland material in a 230 MeV, 300 NA cyclotron room for a proton therapy facility was investigated. The results from PHITS simulations provide insights into the potential of Portland material in reducing radiation levels in proton therapy rooms, contributing to the safety and efficiency of such facilities. This analysis is essential for optimizing shielding design and ensuring compliance with safety regulations in proton therapy facilities.
Dose Analysis in Boron Neutron Capture Therapy on Prostate Cancer using PHITS Program Version 3.32 Fernando, Rio Agustian Gilang; Dwijananti, Pratiwi; Masturi, Masturi; Sunarno, Sunarno; Sardjono, Yohannes
Jurnal Penelitian Pendidikan Vol. 42 No. 2 (2025): October 2025
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jpp.v42i2.34883

Abstract

Prostate cancer is the second most common cancer in male worldwide. Boron Neutron Capture Therapy (BNCT) offers cancer treatment with minimum side effects. BNCT is radiation therapy that uses the 10B isotope and neutron beams which can selectively destroy tumor cells. The resulting radiation dose cannot be measured directly, so a computational method is needed to calculate the dose. The aim of this research is to determine the effective boron concentration, determine the optimal direction of irradiation, and determine the duration of irradiation time at an effective boron concentration for BNCT of prostate cancer. The computational method used is the Monte Carlo method with PHITS Version 3.32 software. The phantom used is an adult male ORNL phantom. The type of prostate cancer modeled is adenocarcinoma with an intermediate risk group. The neutron source is a 30 MeV cyclotron. Variations in 10B concentrations used were 100, 110, 120, 130, 140, and 150 µg/g boron/cancer tissue. The variations in direction used are: anterior-posterior, lateral-anterior oblique, and left-lateral. This study yield that the effective boron concentration used for BNCT in prostate cancer is 150 µg/g boron/cancer tissue. The most optimal radiation direction for BNCT of prostate cancer is the anterior-posterior direction. The duration of irradiation time required for a boron concentration of 150 µg/g boron/cancer tissue is 1 hour 16 minutes 10 seconds.
Co-Authors Aris Haryadi, Aris Bilalodin Bilalodin Ferdy Semuel Rondonuwu Fernando, Rio Agustian Gilang Giner Maslebu Isman Mulyadi Triatmoko, Isman Mulyadi Jodelin Muninggar, Jodelin Kasesaz, Yaser Masturi Masturi Oktaviana, Aditya Tri Pratiwi Dwijananti Sunarno Sunarno Suyanto, Damar Adhiwidya Syväjärvi, Mikael Wijaya, Gede Sustresna Yayi Suryo Prabandari