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All Journal PHARMACON Majalah Biomorfologi (Biomorphology Journal) Nusantara Hasana Journal Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine
Selvi Marcellia
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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EFFECTIVENESS OF THE LARVACIDE ETHANOL EXTRACT OF SOURSOP (Annona muricata L.) LEAVES AGAINST Aedes aegypti LARVA Selvi Marcellia; Tiara Inggrit Margareta; Agustina Retnaningsih
Majalah Biomorfologi Vol. 34 No. 1 (2024): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v34i1.2024.45-51

Abstract

Highlights Dengue fever, caused by mosquitoes known as Aedes aegypti, can be avoided by applying larvicides while the insects are still in their larval stage. The extract from soursop leaves at a concentration of 3% is the most effective for Aedes aegypti larvae, resulting in 100% mortality.   Abstract Background: Dengue Hemorrhagic Fever (DHF) is an infectious disease caused by one of the four serotypes of dengue virus transmitted through mosquitoes, especially Aedes aegypti and Aedes albopictus. As the Aedes aegypti mosquito-borne DHF illness is still in its larval stage, it can be prevented by utilizing larvicides. A more secure and efficient method to eliminate mosquitoes is by using natural larvicides. Underutilized soursop leaves contain secondary metabolite components that can potentially be larvicides, such as annonins, saponins, flavonoids, and tannins. Objective: This study was to determine the effectiveness of soursop leaf extract as a larvicide in controlling Aedes aegypti vectors and to determine the most effective concentration of soursop leaf extract as an Aedes aegypti larvicide. Material and Method: The study was an analytic observational study utilizing a cross-sectional methodology. This study was carried out from March to May 2022. Soursop leaves were extracted using the percolation method, employing a solvent of 96% ethanol with alkaloids, flavonoids, saponins, and tannins. Results: The soursop leaves extract yielded in this study was as much as 131.22 grams (13.12%). The most effective concentration of soursop (Annona muricata L.) leaves was 3%, with a mortality value of 100%, not much different from the value resulting from 1% temephos. The LC50 results obtained a value of 0.163%. Conclusion: Soursop leaf extract was effective as a larvicide against Aedes aegypti mosquito larvae.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAUN TIN (Ficus carica L.) TERHADAP BAKTERI Escherichia coli dan Staphylococcus aureus Muhammad Iqbal Farhan; Dewi Chusniasih; Selvi Marcellia
PHARMACON Vol. 11 No. 1 (2022): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.11.2022.39145

Abstract

ABSTRACTThe leaves of the fig plant that are underutilized contain secondary metabolites that have the potential as antibacterial. The purpose of this study was to determine the effectiveness of the fig leaf extract as an antibacterial against Escherichia coli and Staphylococcus aureus bacteria and to determine the concentration of the fig leaf extract as an antibacterial. Fig leaf extraction method using percolation method using ethanol as a solvent and testing the antibacterial activity of fig leaf extract against Escherichia coli and Staphylococcus aureus bacteria. fig leaf phytochemical screening results. Fig leaf extract has antibacterial activity against Escherichia coli and Staphylococcus aureus with a concentration of 20% with an inhibition zone of 10.50 mm against Escherichia coli bacteria and 5% with an inhibition zone of 1.30 mm against Staphylococcus aureus bacteria. Tin leaf ethanol extract can inhibit the growth of Escherichia coli and Staphylococcus aureus bacteria and has antibacterial activity of Escherichia coli at a concentration of 20% with an inhibition of 10.50 mm with a strong category (10-20 mm) and Staphylococcus aureus at a concentration of 5% with an inhibition of 1 .30 mm and meet the weak category (< 5 mm).Keywords: Tin leaf (Ficus carica L.) antibacterial, Staphylococcus aureus, Escherichia coli.ABSTRAKDaun dari tanaman tin yang kurang termanfaatkan memiliki kandungan senyawa metabolit sekunder yang berpotensi sebagai antibakteri. Tujuan penelitian ini untuk mengetahui ekstrak daun tin efektif sebagai anti bakteri terhadap bakteri Escherichia coli dan Staphylococcus aureus dan untuk mengetahui konsentrasi ekstrak daun tin sebagai antibakteri. Metode ekstraksi daun tin dengan metode perkolasi menggunakan pelarut etanol dan uji aktivitas antibakteri ekstrak daun tin terhadap bakteri Escherichia coli dan Staphylococcus aureus. hasil skrining fitokimia Daun Tin. Ekstrak daun tin memiliki aktivitas antibakteri terhadap bakteri Escherichia coli dan Staphylococcus aureus dengan konsentrasi 20% dengan zona hambat 10,50 mm terhadap bakteri Escherichia coli dan 5% dengan zona hambat 1,30 mm terhadap bakteri Staphylococcus aureus. Ekstrak etanol Daun Tin dapat menghambat pertumbuhan bakteri Escherichia coli dan Staphylococcus aureus dan memiliki aktivitas antibakteri Escherichia coli pada konsentrasi 20% dengan hambatan sebesar 10,50 mm dengan kategori kuat (10-20 mm) dan Staphylococcus aureus pada konsentrasi 5% dengan hambatan sebesar 1,30 mm dan memenuhi kategori lemah (< 5 mm).Kata kunci: Daun Tin (Ficus carica L.) antibakteri, Staphylococcus aureus, Escherichia coli
Manajemen Nyeri Pasca Operasi Laparotomi : Tinjauan Pustaka Haya Falisa Karimah; Ari Wahyuni; Selvi Marcellia; Dendy Maulana
Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine Vol. 11 No. 2 (2024): Jurnal Kesehatan dan Agromedicine
Publisher : Fakultas Kedokteran Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jka.v11i2.pp62-66

Abstract

Manajemen nyeri pasca operasi merupakan aspek penting dalam perawatan pasien setelah menjalani laparotomi. Penggunaan opioid sebagai dasar manajemen nyeri sering kali dibatasi oleh efek samping yang berpotensi berbahaya, seperti kecanduan dan depresi pernapasan. Oleh karena itu, pendekatan multimodal yang menggabungkan berbagai teknik analgesik dan metode non-farmakologis menjadi semakin relevan. Penelitian ini bertujuan untuk mengeksplorasi efektivitas strategi manajemen nyeri multimodal dalam mengurangi penggunaan opioid dan meningkatkan pemulihan pasca operasi. Hasil menunjukkan bahwa terapi ini tidak hanya mengurangi efek samping yang terkait dengan penggunaan opioid, tetapi juga meningkatkan kontrol nyeri secara keseluruhan dan kualitas hidup pasien. Dengan demikian, penerapan strategi manajemen nyeri yang komprehensif dan terintegrasi diharapkan dapat memberikan hasil pemulihan yang lebih baik bagi pasien pasca laparotomi. Selain itu, penelitian ini menekankan pentingnya intervensi non-farmakologis, seperti teknik relaksasi dan edukasi preoperasi, sebagai bagian dari manajemen nyeri yang efektif. Manajemen ini diharapkan dapat mengatasi tantangan global terkait penggunaan opioid yang berlebihan dan meningkatkan kualitas hidup pasien.
POLYGENIC RISK SCORE SEBAGAI PREDIKTOR DIABETES MELLITUS TIPE 2: SYSTEMATIC RIVIEW Ni Ketut Diah Ayu Pramisswari; Ety Apriliana; Selvi Marcellia; Putu Ristyaning Ayu Sangging
Nusantara Hasana Journal Vol. 5 No. 8 (2026): Nusantara Hasana Journal, January 2026
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i8.1881

Abstract

Type 2 diabetes mellitus (T2DM) is a multifactorial metabolic disease with a significant genetic contribution. Polygenic risk score (PRS) has been developed to integrate the cumulative effects of multiple genetic variants to improve T2DM risk prediction. This Systematic review aimed to evaluate the role of PRS in predicting T2DM incidence, disease progression, and related complications across different populations. This study was conducted in accordance with the PRISMA guidelines, with a literature search performed using the PubMed database and keywords related to PRS and T2DM. Included studies were observational in design and assessed the association between PRS and T2DM incidence or clinical outcomes. Three main studies with case-control, cross-sectional, and cohort designs were analyzed. The results demonstrated that PRS was significantly associated with increased T2DM risk, disease progression, and metabolic complications such as liver fibrosis, including in the context of organ transplantation. Integration of PRS with traditional clinical risk factors improved predictive performance. PRS has the potential to support precision-based T2DM risk stratification, although further cross-population validation is still required.
Co-Authors Ari Wahyuni Dendy Maulana Dewi Chusniasih Ety Apriliana Haya Falisa Karimah Muhammad Iqbal Farhan Ni Ketut Diah Ayu Pramisswari Retnaningsih, Agustina Sangging, Putu Ristyaning Ayu Tiara Inggrit Margareta