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All Journal Jurnal Jamu Indonesia Jurnal Mandala Pharmacon Indonesia Jurnal Pengabdian Kepada Masyarakat Journal of Public Health and Pharmacy Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Tien Wahyu Handayani
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Uji Efektivitas Antihiperglikemia Daun Kelor (Moringa Oleifera Lam.) dan Gambaran Histopatologi Pankreas Tikus Putih Jantan (Rattus Norvegicus) yang Diinduksi Streptozotocin Joni Tandi; Ida Yanti Palinggi; Seblin Tonapa Rammang; Tien Wahyu Handayani
Jurnal Jamu Indonesia Vol. 4 No. 2 (2019): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (16854.593 KB) | DOI: 10.29244/jji.v4i2.131

Abstract

Penelitian ini bertujuan untuk menguji efek penurunan kadar glukosa darah dan gambaran histopatologi pankreas dari daun kelor pada tikus putih jantan, serta senyawa metabolit sekunder pada ekstrak fraksi n-heksan, fraksi etil asetat dan fraksi etanol-air. Pengujian menggunakan 35 ekor tikus dibagi menjadi tujuh kelompok dengan perlakuan yaitu kelompok kontrol normal, kontrol negatif, kontrol positif metformin, kontrol positif simvastatin, dan kelompok uji (fraksi n-heksan, fraksi etil asetat dan fraksi etanol air) dengan dosis 300 mg/kg BB. Pengukuran kadar glukosa darah dilakukan pada hari ke-0, 35, 42 dan 49 setelah diberi perlakuan. Hasil penelitian menunjukkan bahwa terdapat senyawa metabolit sekunder fraksi etil asetat dan etanol air yaitu alkaloid, flavonoid, saponin, tannin dan steroid. Fraksi n-heksan hanya terdapat saponin. Fraksi etanol air ekstrak daun kelor pada dosis 300 mg/kg BB yang memiliki efek penurunan kadar glukosa darah sebesar 114,6 (mg/dL) dan nilai kerusakan pancreas rata-rata 2. Lebih baik dibandingkan dengan fraksi n-heksan dan etil asetat.
Uji Ekstrak Etanol Daun Kemangi Terhadap Kadar Glukosa Darah, Dan Gambaran Histopatologi Pankreas Tikus Yang Diinduksi Streptozotocin Joni Tandi; Niswatulfahriyati Niswatulfahriyati; Nurmadinah Nurmadinah; Tien Wahyu Handayani
Jurnal Mandala Pharmacon Indonesia Vol. 5 No. 02 (2019): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi STIKES Mandala Waluya Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v5i02.41

Abstract

Penelitian ini bertujuan menguji ada tidaknya kandungan senyawa metabolit sekunder pada ekstrak etanol daun kemangi,efek penurunan kadar glukosa darah dari ekstrak etanol daun kemangipada tikus putih jantan yang diinduksi streptozotocin.Penelitian ini merupakan penelitian eksperimen laboratorium dengan menggunakan hewan uji sebanyak 30 ekor tikus putih jantan dibagi menjadi 6 kelompok dan tiap kelompok terdiri dari 5 ekor tikus dengan rincian kelompok I sebagai kontrol normal, kelompok II sebagai kontrol negatif yang diberikan suspensi Na-CMC 0,5%, kelompok III sebagai kontrol positif yang diberikan suspensi glibennklamide dan kelompok IV,V,VI sebagai kelompok uji diberikan ekstrak etanol daun keamngi, dengan masing-masing dosis 200 mg/kg BB, 400mg/kg BB dan 800mg/kg BB . Perlakuan diberikan selama 14 hari dan dilakukan pengukuran kadar glukosa darah diukur dengan glukometer pada hari ke-0, 7, 14, 21 dan 28. Data hasil pengujian kadar glukosa darah dan menggunakan uji one way Anova pada tariff kepercayaan 95% kemudian dilanjutkan dengan uji Least Significant Difference (LSD), dan data hasil skoring tingkat kerusakan pankreas dianalisis dengan uji Kruskal-Wallis dilanjutkan dengan uji Mann-Whitney untuk melihat perbedaan antar perlakuan. Hasil penelitian menunjukkan bahwa terdapat senyawa metabolit sekunder pada ekstrak etanol daun kemangi yaitu flavonoid, saponin, dan tanin: pemberian ekstrak etanol daun kemangi memberikan efek menurunkan kadar glukosa darah pada tikus putih yang diinduksi streptozotocin: Hasil penelitian menunjukkan bahwa pengaruh ekstrak etanol daun kemangi yang memberikan hasil yang maksimal untuk menurunkan kadar glukosa darah dan regenerasi jaringan pankreas
POTENSI ANTIDIABETIK EKSTRAK ETANOL DAUN MATOA(Pometia pinnata) PADA TIKUS PUTIH JANTAN Joni Tandi; Afriani S; Nadira; Handayani KR; Wirawan W; Afrizal; Tien Wahyu Handayani
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 8 No. 1 (2022): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v8i1.521

Abstract

Diabetes Mellitus is a metabolic disease characterized by high blood glucose levels which is commonly called hyperglycemia due to lack of insulin secretion. One of the matoa plants (Pometia pinnata) that has been used as a traditional medicine is matoa leaves which are efficacious as diabetes mellitus. The purpose of this study was to determine the secondary metabolite compounds in the ethanol extract of matoa leaves, as well as to determine the potential dose of ethanolic extract of matoa leaves which was effective in reducing blood glucose levels and on the histopathological description of the pancreas of male white rats induced by Streptozotocin. This study used a laboratory experimental method, divided into 6 treatment groups, each group consisting of 5 rats, namely normal control, negative control, positive control, treatment groups with doses of 100, 200, and 300 mg/kg body weight. Data were analyzed using One Way ANOVA statistical test at 95% confidence level followed by LSD test to see differences between treatments. The results showed that the ethanolic extract of matoa leaves contained secondary metabolites of alkaloids, flavonoids, saponins, tannins, and steroids. at a dose of 300 mg/kg BW showed effective results in reducing blood glucose levels with an average decrease of 99.6 mg/dL and the ethanol extract of matoa leaves had the potential to regenerate pancreatic cells in streptozotocin-induced male white rats of 0. 6±0.54
Optimalisasi Potensi Tanaman Herbal Lokal Melalui Pelatihan Pembuatan Minyak Gosok di Desa Petiro, Kabupaten Poso Joni Tandi; Tien Wahyu Handayani; Vivi Gretia Triposa
PaKMas: Jurnal Pengabdian Kepada Masyarakat Vol 5 No 2 (2025): November 2025
Publisher : Yayasan Pendidikan Penelitian Pengabdian Algero

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54259/pakmas.v5i2.4075

Abstract

The use of herbal plants in modern medicine is increasing, notably for their antioxidant properties that effectively reduce free radicals. The growing "back to nature" trend, coupled with the high cost of modern pharmaceuticals, has encouraged communities to seek safer alternative treatments. This community service program was designed to enhance the capabilities of residents in Petiro Village, East Pamona District, Poso Regency to independently produce herbal massage oil as a sustainable health solution. Methodologically, the program employed a combination of lectures, practical demonstrations, and interactive discussions. Evaluation was conducted through pre-tests and post-tests administered to 22 participants to measure knowledge acquisition. The implementation process followed a systematic approach: preparation of raw materials, processing them into dry simplicia, and formulating massage oil using essential oils combined with natural herbs including ginger, turmeric, red betel leaf, garlic, and onion. Results demonstrated a remarkable improvement in community understanding, rising from 25% to 100% following the training intervention. This improvement encompassed comprehensive knowledge of the benefits, production techniques, and understanding of herbal massage oil ingredients. The training successfully fostered practical skills that participants could immediately apply. The significant knowledge transfer achieved has important implications for developing local herbal massage oil production as a sustainable enterprise, potentially improving both community health outcomes and economic prosperity in rural communities. Additionally, this initiative contributes to preserving traditional herbal knowledge while adapting it to contemporary health needs, creating a viable model for other rural communities seeking health self-sufficiency.
Innovative Oil from STIFA Pelita Mas for Glycemic Control and Tissue Regeneration in Diabetic Rats Joni Tandi; Muthmainah Tuldjanah; Tien Wahyu Handayani
Journal of Public Health and Pharmacy Vol. 6 No. 1: MARCH 2026
Publisher : Pusat Pengembangan Teknologi Informasi dan Jurnal Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jphp.v6i1.7192

Abstract

Introduction: Diabetes mellitus is a significant global health problem with increasing prevalence in Indonesia. Conventional management of diabetes mellitus is often accompanied by side effects and high costs, prompting the search for alternatives based on natural ingredients. STIFA Pelita Mas Herbal Oil is an innovative formulation that combines various efficacious natural ingredients, but its effectiveness on histopathological changes in pancreatic and kidney tissues due to diabetes has not been comprehensively explored. This study aims to evaluate the effectiveness and mechanism of action of STIFA Pelita Mas Herbal Oil on reducing blood glucose levels, repairing pancreatic tissue damage, and kidneys in a streptozotocin-induced rat model. Methods: This study used a quantitative approach with an experimental design on 30 male white rats (Rattus norvegicus) divided into 6 treatment groups. STIFA Pelita Mas Herbal Oil is made by combining simplicia (Shallots, Garlic, Ginger, Curcuma zanthorrhiza, Lemongrass red, and Piper ornatum leaves) with various oils (VCO, eucalyptus oil, citronella oil, olive oil, and cinnamomum cullilawan). Diabetes was induced using streptozotocin (40 mg/kg BW) intraperitoneally. The parameters measured included blood glucose levels and histopathological changes in the kidneys and pancreas with Hematoxylin-Eosin staining. Data were analyzed using One Way ANOVA followed by the LSD or Kruskal-Wallis test. Result: The results showed that all three herbal oil formulas were able to lower blood glucose levels, with formula 1 and formula 3 showing comparable effectiveness to glibenclamide on day 28. In histopathological observations of the kidneys, formula 3 showed the best effectiveness in repairing damage to renal tubule and glomerular cells with a damage score of 0, equivalent to normal controls. Similarly, in histopathological observations of the pancreas, formula 3 showed the highest effectiveness in repairing damage to pancreatic beta cells with a damage score of 0.2, not significantly different from normal and positive controls. Conclusion: Stifa Pelita Mas herbal oil, especially formula 3, has the potential as an effective antidiabetic agent in lowering blood glucose levels and repairing tissue damage in the kidneys and pancreas due to diabetes. Future research should focus on dose variations to see at what dose this oil is effective.
Co-Authors Afriani S Afrizal Handayani KR Ida Yanti Palinggi Joni Tandi, Joni Muthmainah Tuldjanah Nadira Niswatulfahriyati Niswatulfahriyati Nurmadinah Nurmadinah Seblin Tonapa Rammang Vivi Gretia Triposa Wirawan W