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I Gede Pande Sastrawan
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Medicine & Pharmacology

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PERAN HIPOKSIA PADA PATOGENESIS PENYAKIT GINJAL Sastrawan, I Gede Pande; Suwitra, Ketut
journal of internal medicine Vol. 9, No. 1 Januari 2008
Publisher : journal of internal medicine

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Abstract

Chronic kidney disease is a current major worldwide health problem with an increasing prevalency.Kidney is a sensitive organ with hypoxic condition relate to its high tubular epithelial cells and vascular oxygenconsumption. Chronic peritubular ischemia may occur through several interrelating mechanisms. The activationof local renin-angiotensin system, angiotensin II, could induce hypoxia by means of hemodinamic and nonhemodinamicmechanisms.Anemia in renal disease could accelerate the decline of renal function through the induction oftubulointerstitial hypoxia. Non Steroidal Anti Inflamatory Drugs (NSAID) could evoke renal medullar hypoxiaby its regional hypoperfusion mechanism and the escalation of tubular transport. The Outer region of renalmedulla and tubulus are main target of hypoxic renal damage. The mechanism of hypoxia induced AcuteKidney Disease involves renal vascular and tubulus through the reduction of blood flow and the increasing oftubular oxygen demands. The Patofisiology of hypoxia induced chronic kidney disease occurs bytubulointerstitial damage which induce fibrogenesis, causing interference of peritubular blood flow and oxygenconsumption.
PREVALENSI ASMA BRONKIAL ATOPI PADA PELAJAR DI DESA TENGANAN Sastrawan, I Gede Pande; Suryana, Ketut; Ngurah Rai, I B
journal of internal medicine Vol. 9, No. 1 Januari 2008
Publisher : journal of internal medicine

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Abstract

Asthma as one of the allergic diseases continuos to be a major public health problem in developed anddeveloping countries. We carried out a population-based survey to search the prevalence of atopic asthma inschool children of Tenganan, Manggis-Karangasem. Asthma was diagnose by quisioner and bronchodilator test.Atopic asthma define as asthma patients with total IgE > 100 IU/ml and or skin prick test 3 mm. Five hundredfourteen (91.5%) students out of of 562 students were were invited, participated the study. Thirty six (7%)students were diagnosed asthma based on peak expiratory flow variability after brochodilator test, stratified bysex there were 13 (36.1%) boys and 23 (63.9%) girls and 9 (25.0%) primary school children, 14 (38.9%) juniorhigh, 13 (36.1%) high school, respectively. Mean of age, serum IgE total and wheal diameter was 13.42 ± 3.26year, 1551.83 ± 2008.19 IU/ml, 22.9±3.4% and 3.58 ± 0.99 mm, respectively. Out of 36 asthma patients, 35(97.2%) diagnosed atopic asthma consist of 12 (34.3%) boys and 23 (65.7%) girls, and 1 (2.8%) diagnosednonatopic asthma.
Co-Authors I B Ngurah Rai Ketut Suryana Ketut Suwitra