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All Journal Jurnal Agroindustri Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Amriani Sapra
Sekolah Tinggi Ilmu farmasi Makassar
Agriculture, Biological Sciences & Forestry Chemistry Electrical & Electronics Engineering Energy Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Nursing Public Health

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UJI STABILITAS DAN IRITASI FORMULA KRIM ANTI NYERI EKSTRAK ETANOL DAUN KELOR (Moringa oleifera) Amriani Sapra; Suwahyuni Mus; Rifka Malluka; Dwirandy Dwirandy
Jurnal Ilmiah Manuntung Vol 6 No 2 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i2.380

Abstract

Moringa oleifera leaf contains quercetin act as an analgesic by inhibiting cyclooxygenase and lipooxygenase. These enzymes interfere synthesis of prostaglandins by arachidonic acid and lead to reduce pain. This study aimed to obtain a physically stable M/A cream formula from the lyophilized ethanol extract of Moringa leaf and to determine the irritation effect. The cream prepared with variations of cetyl alcohol concentration F1 (2%), F2 (4%,) and F3 (6%). The cream stability was determined with organoleptic, homogeneity, type of emulsion, pH, viscosity, and spreadability parameters after accelerated condition. The Irritancy test was determined to the Albino Oryctolagus cuniculus. The results showed that F1 has the best stability than F2 and F3 and showed irritation index 0,5 classified as moderate irritation.
FORMULASI GRANUL INSTAN EKSTRAK BUAH BUNI (Antidesma bunius L.) SEBAGAI MINUMAN ANTIOKSIDAN Nur Khairi Jalil Genisa; Amriani Sapra; Suryani Tawali; Maulita Indrisari
Jurnal Agroindustri Vol. 14 No. 1 (2024): May 2024
Publisher : BPFP Faperta UNIB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31186/jagroindustri.14.1.1-10

Abstract

Buni is a plant that is widespread in Asia, especially Indonesia. Buni fruit has been reported to contain anthocyanins which have activity as flavonoids, antiocyanins, saponins, alkaloids and as high antioxidant agents, but because Buni fruit is seasonal so raw materials depend on the season, therefore to increase availability it needs to be extracted and formulated in a form preparations. The purpose of this study was to obtain an instant granule formula that meets the physical characteristics and to determine the IC50 value of the antioxidant activity of the instant granule preparation of buni fruit extract (Antidesma bunius L.). The extract was prepared by extraction method using 70% ethanol solvent with the addition of 3% citric acid for 3x24 hours. Instant granules were prepared using the wet granulation method using varying concentrations of PVP as a binder, namely 1%, 3% and 5%. Furthermore, the physical characteristics were evaluated including flow properties, moisture content, soluble time, then antioxidant activity was determined based on the IC50 value using the DPPH method. The results showed that F1 and F2 had good flow properties and F3 had very good flow properties, the moisture content was around 2-4% and the dissolution time was 2-3 minutes. Based on the test results obtained formula 3 with a PVP concentration of 5% is a formula that meets the physical requirements of granules and an IC50 value of 65.94 µg/mL is included in the strong antioxidant category.
Co-Authors Dwirandy Dwirandy Maulita Indrisari, Maulita Nur Khairi Jalil Genisa Rifka Malluka Suryani Tawali Suwahyuni Mus