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Florenly Florenly
Master of Clinical Medicine, Faculty of Medicine, Universitas Prima Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Physics Transportation

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Effect of Turmeric Ethanol Extract Ointment (Curcuma Longa) on the Healing of Grade II Burns in Wistar Rats (Rattus Norvegicus) Ji Junfeng; Florenly Florenly; Johannes Bastira Ginting; Fioni Fioni
Budapest International Research in Exact Sciences (BirEx) Journal Vol 3, No 4 (2021): Budapest International Research in Exact Sciences, October
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birex.v3i4.3053

Abstract

Burns is still a choir for clinical nurses as severe burns have led to high postburn morbidity. In Indonesia, the death rate from burns is still high at about 40%, mainly caused by severe burns. Curcuma longa herbal products have several such antioxidants, anti-inflammatory, anti-cancer. The purpose of this study was to find out the phytochemical content and effect of turmeric Ethanol Extract Ointment (Curcuma longa Linn) in curing grade II burns in Wistar rats (Rattus norvegicus). This study is an experimental study with a pre and post-test control group design approach. This research was conducted at Riwandi Pet Shop and Animal House and Laboratoirum Taxonomy of Plants, Department of Biology, Faculty of Mathematics and Natural Sciences (FMIPA), the University of North Sumatra in February-March 2021. The study sampled 20 turmeric rhizomes and male Wistar rats (Rattus norvegicus) divided into 4 treatment groups. Independent variables of topical formulation (base ointment, nebacetin ointment®, Turmeric Ethanol Extract Ointment (Curcuma longa) 5% and Turmeric Ethanol Extract Ointment (Curcuma longa) 10%, as well as independent variables that include wound contraction and epithelial period. The results of phytochemical screening in turmeric found phytochemicals in the form of flavonoids, alkaloids, and tannins. The results of the study obtained significant differences in the epithelial period of the standard group, turmeric ointment 5% and 10% against the control group. However, in the turmeric ointment group and the standard group, there was no difference in epithelialization periods. This is evident from the value P < 0.05 (Value P = 0.028). Where the wound contraction rate of turmeric ointment is 10% better than nebacetin ointment as standard. But in both turmeric ointments, both 5% and 10% and nebacetin ointment as standard did not show significant differences in the parameters of the epithelial period.
Analysis of Grade II Burns Healing from Andaliman Fruit Ethanol Extract Ointment (Zanthoxylum Acanthopodium Dc.) in Wistar Rats (Rattus Norvegicus) Li Sha; Florenly Florenly; Johannes Bastira Ginting; Fioni Fioni
Budapest International Research in Exact Sciences (BirEx) Journal Vol 3, No 4 (2021): Budapest International Research in Exact Sciences, October
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birex.v3i4.3054

Abstract

The prevalence of injuries has increased every year, from riskesdas results data in 2013 reported that burns are the sixth cause of accidental injuries with a prevalence of 0.7 percent of the Indonesian population. Andaliman fruit extract with various phytochemicals has active physiological activity as a potential antioxidant and antimicrobial. The study aims to explore the wound healing effects of andaliman fruit ethanol extract. This study was an experimental study using 20 rats divided into 4 groups (Control, Standard, Essential Oil 10%, and Essential Oil 15%). Wound healing parameters are assessed through wound contraction and epithelial period. Samples of andaliman fruit used in this study were obtained from one of the traditional markets in the city of Medan. Essential oils are obtained from the hydrodistillation process. The results of the study showed significant differences in the epithelial period of the standard group, 10% and 15% in the control group. However, in the andaliman ointment group and the standard group, there was no difference in the epithelial period. This is evident from the value P < 0.05 (Value P = 0.029). The conclusion of the healing effects of burns possessed by andaliman ointment both 10% and 15% and nebacetin ointment as standard shows a significant difference. Where the wound contraction rate of your ointment is 15% better than nebacetin ointment as standard. But in both andaliman ointments, both 10% and 15% and nebacetin ointment as standard did not show significant differences in the parameters of the epithelial period.
Anti-Dislipidemia Effectiveness Test of Turmeric Ethanol Extract (Curcuma Longa) in Male Wistar Mice Given Propylthiouracil (PTU) Ke Huajing; Florenly Florenly; Johannes Bastira Ginting; Fioni Fioni
Budapest International Research in Exact Sciences (BirEx) Journal Vol 4, No 1 (2022): Budapest International Research in Exact Sciences, January
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birex.v4i1.3475

Abstract

Dyslipidemia is a lipid metabolic disorder that is a risk factor for coronary heart disease (CHD). According to the American Heart Association, data from 2013 to 2016, as many as 92.8 million adults in America have total cholesterol of more than 200 mg / dL. Curcumin, the main compound in turmeric, can lower cholesterol levels due to inhibiting the reabsorption of cholesterol derived from the outside (exogenous) and increasing the enzyme HMG-CoA reductase inhibitor so that fat synthesis can run well. The purpose of this study was to find out the effectiveness of mangosteen peel ethanol extract as an anti-dyslipidemia in male Wistar rats given Propylthiouracil (PTU). This study is an experimental study with a Pre-test and Post-test group only control design approach that uses male Wistar rats as test animals and turmeric extract. The study was conducted in March 2021, at the Herbarium Medanese FMIPA USU, the Pharmacognosy Laboratory of the FACULTY of Pharmacy USU, and the Laboratory of Pharmaceutical Pharmacology USU. Descriptive data analysis (Central tendency and Dyspersi) in the form of lipid profiles (LDL, HDL, Total Cholesterol, and Triglycerides), color, texture, weights. Then analyzed with One-Way Anova if the distributed data is normal, if the distributed data is not normal, then the Kruskal-Wallis test is used. The results and conclusions, turmeric ethanol extract (Curcuma Longa) III (151.70 ± 0.95 mg/dl) can significantly decrease total cholesterol compared to the control group (178.50 ± 6.05mg/dl) (P-value < 0.05). Turmeric ethanol extract (Curcuma Longa) III (110.00 ± (109-112) mg/dl) may significantly lower triglyceride levels compared to the control group (167.00 (162-179) mg/dl). (Value P = 0.027). Turmeric ethanol extract (Curcuma Longa) III (68.50 ± 1.28 mg/dl) significantly lowered LDL levels compared to the control group (107.20 ± 3.60 mg/dl). (P-value < 0.05). Turmeric ethanol extract (Curcuma Longa) III, (61.00 (60-62) mg/dl) may significantly increase HDL levels compared to the control group (28.50 (37-45) mg/dl). (Value P = 0.027). Turmeric ethanol extract (Curcuma Longa) III significantly lowered SGOT (Value = 0.027) and SGPT (Value P < 0.05) compared to the control group. 
Influence Before and After Early Mobilization of Changes in Pain Levels in Sectio Cesarea Postoperative Clients at Royal Prima Hospital in 2020 Ma Hongjun; Florenly Florenly; Liena Liena; Fioni Fioni
Budapest International Research in Exact Sciences (BirEx) Journal Vol 3, No 4 (2021): Budapest International Research in Exact Sciences, October
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birex.v3i4.3052

Abstract

Sectio Caesarea is artificial labor in which the fetus is born through an incision in the front wall of the abdomen and the uterine wall. The number of Sectio Caesarea patients in Indonesia has exceeded the recommended threshold of the Department of Health > 20%. Surgery can cause postoperative pain in the client, this pain is usually felt 12 to 36 hours after surgery. One of the management of non-famakological treatment of post-section caesarean section pain treatment is early mobilization. Early mobilization aims to accelerate wound healing, improve circulation, and prevent venous static. The purpose of this study was to determine the influence before and after early mobilization of changes in pain levels in postoperative clients of sectio cesarea. This type of research is descriptively correlational, One Group Pretest-Postest, conducted at RSU Royal Prima Medan Petisah, North Sumatra from September to November 2020. The study population ± 43 people. The number of samples using the formula Slovin, so 36 samples were obtained. The selection of samples with non-probability sampling is consecutive sampling. Analysis of data, with a univariate, bivariate, meaningful limit of 0.05 with t-dependent test (paired t-test).The results, the change in pain level score of the pre-test test results of the mean value 3.22, at the time of the post-test test the mean value is 2.17. So the result of the value Z = -6,128 then p-value as much as 0.000 < 0.05 so that it was concluded Ho was rejected and Ha received. Concluded there is an influence of early mobilization of pain changes in postoperative clients sectio caesarea in the room of RSU Royal Prima in 2020.
Co-Authors Fioni, Fioni Ji Junfeng Johannes Bastira Ginting Ke Huajing Li Sha Liena Liena Ma Hongjun