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Fioni, Fioni
Universitas Prima Indonesia
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Antioxidant and Anti-Hyaluronidase Activities of Dragon Fruit Peel Extract and Kaempferol-3-O-Rutinoside Liana, Liana; Rizal, Rizal; Widowati, Wahyu; Fioni, Fioni; Akbar, Khainir; Fachrial, Edy; Lister, I Nyoman Ehrich
Jurnal Kedokteran Brawijaya Vol 30, No 4 (2019)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (172.286 KB) | DOI: 10.21776/ub.jkb.2019.030.04.3

Abstract

Aging is a natural process in human life and is triggered by the presence of free radicals (ROS). The use of antioxidants from natural ingredients is one of the breakthroughs to overcome aging and counteract the harmful effects caused by the free radicals. This study aimed to determine and compare the antioxidant activity of H2O2 scavenging and hyaluronidase inhibition of red dragon fruit peel extract (DFPE) and kaempferol-3-o-rutinoside (KOR) compounds. Dragon fruit peel extract (DFPE) is obtained through extraction by maceration method using 70% ethanol solvent. The design of this study included antioxidant and anti-aging activity assay of EKBN and KOR at the series concentration of 15.63; 31.25; 62.50; 125; 250; 500 µg/mL through H2O2 scavenging, as well as the DFPE and KOR hyaluronidase inhibition assay at the series concentration of 5.21; 10.42; 20.83; 41.7; 83.33; 166.67 µg/mL. EKBN shows that the average activity of H2O2 scavenging is lower than KOR. In addition, the IC50 values of KOR for H2O2 scavenging is lower (351.46±2.30ug/mL) than DFPE (409.64±23.17ug/mL). While, KOR also has higher values of inhibitory activity than of the DFPE. However, the IC50 value of KOR for hyaluronidase inhibition activity was 84.07±10.46µg/mL, equivalent to the IC50 value of DFPE (85.32±10.24µg/mL). The presence of antioxidant and anti-aging activity in the EKBN is probably caused by betalain and the KOR compound itself contained in red dragon fruit. The results of the paired-samples T-test on antioxidant activity and anti-aging of DFPE and KOR showed non-significant difference. Thus, DFPE has an equivalent antioxidant and anti-aging through H2O2 scavenging and hyaluronidase activity as possessed by the KOR compound.
UJI EFEKTIVITAS EKSTRAK LENGKUAS MERAH (Alpinapurpurata K.Schum) DALAM MENGHAMBAT PERTUMBUHAN BAKTERI Eschericia coli SECARA IN VITRO Fioni Fioni
Jurnal Keperawatan Priority Vol. 4 No. 2 (2021)
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jukep.v4i2.1901

Abstract

Red ginger with the Latin name Alpina purpurata K. Schum is a plant of the family zingiberaceae (family ginger family) which has several medical benefits. Zingiberaceous has about 50 genera and 1300 species spread throughout the world. In relation to the flavonoid content, routine, kaempferol-3-rutionoside and kaemferol-3-oliucronide in red ginger (Alpina purpurata K. Schum) as antimicrobial, then to prove this, the trials of antimicrobial efficacy in vitro by diffusion disc (method Kirby & Bauer test) against Escherichia coli which is a gram negative bacteria. The results were analyzed with SPSS 20 software. The results showed that red ginger extract (Alpina purpurata K. Schum) effective in the course of Escherichia coli growth was at 100% concentration. The mean inhibition zone diameter was 7.825 mm at 25%, 8,625 mm at concentration 50%, 9,350 mm at concentration 75%, and 10.7 mm at 100% concentration.
KARAKTERISTIK DEMAM BERDARAH DENGUE PADA ANAK DI RUMAH SAKIT UMUM ROYAL PRIMA MEDAN Fioni Fioni
PRIMER (Prima Medical Journal) Vol. 5 No. 1 (2020): Edisi April
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/pmj.v3i1.1158

Abstract

Dengue disease is caused by dengue virus from Arbovirus B group, that is arthropod-bone virus or virus spread by arthropod. This virus belongs to the genus Flavivirus of the Flaviviridae family. The type of research used is case study design research, descriptive with retrospective approach. The required sample size is 100 patient medical record data. The results of the study were aged 15-19 (29%), based on the most sexes were men (59%), based on the patient's main complaint were all high fever (100%), based on the additional complaints most were nausea + vomiting + rash + headache + (23%), based on most inspection was the rash (40%), based on the patient's palpation were all soepel (100%), based on percussion of patients all were tympanic (100%), based on the most frequent tourniquet test is Positive (56%), based on the most common hemoglobin examination (89%), based on the most common hematocrit examination (89%), , based on the most frequent leukocyte examination is abnormal (89%), based on platelet based patients all are thrombocytopenia (100%).
Exploration of the Analgesic and Antipyretic Effects of Mangosteen Peel Methanol Extract (Garcinia mangostana L) in Male Wistar Rats Jiang Fan; Florenly Florenly; Liena Liena; Fioni Fioni
Budapest International Research in Exact Sciences (BirEx) Journal Vol 3, No 4 (2021): Budapest International Research in Exact Sciences, October
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birex.v3i4.2634

Abstract

Analgetic-antipyretic is a compound that is often used to reduce pain and fever. A natural plant that has the potential as an antipyretic analgesic compound is mangosteen fruit (Garcinia mangostana L). This study aims to find out the analgesic and antipyretic effects of mangosteen peel methanol extract on male Wistar rats. This type of research is experimental, design Post-Test Only Control Group Design. The research was conducted at the Pharmaceutical Laboratory of the University of North Sumatra Medan, January - March 2021. The test was conducted using 25 mice divided into 5 groups. Data analysis uses SPSS test one-way ANOVA if the data does not distribute normal Kruskal-Wallis. The results of the study 5 hours after treatment, the body temperature of the mice experienced a significant change, the value of P < 0.05 (Value P = 0.004). Where the methanol extract group of mangosteen skin III showed the lowest body temperature 5 hours after treatment which was 36.14 ± 0.12oC and the methanol extract group Mangosteen-III skin also showed a significant difference to the control group that showed the highest body temperature of 37.36 ± 0.46oC. The least amount of geliat found in the mangosteen-III skin methanol extract group was 5.22 ± 1.91 and this number showed a significant difference with the mangosteen- I skin methanol extract group (12.81 ± 3.12) and the control group (11.10 ± 1.91). In conclusion, the results of mangosteen skin testing have antipyretic and antipyretic effects, found at 5 hours after treatment and the highest dose is 750 mg/ kgBB. Meanwhile, the results of the hematologic examination showed a significant decrease in line with the increase in the dose of mangosteen skin methanol extract given.
Effect of Turmeric Ethanol Extract Ointment (Curcuma Longa) on the Healing of Grade II Burns in Wistar Rats (Rattus Norvegicus) Ji Junfeng; Florenly Florenly; Johannes Bastira Ginting; Fioni Fioni
Budapest International Research in Exact Sciences (BirEx) Journal Vol 3, No 4 (2021): Budapest International Research in Exact Sciences, October
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birex.v3i4.3053

Abstract

Burns is still a choir for clinical nurses as severe burns have led to high postburn morbidity. In Indonesia, the death rate from burns is still high at about 40%, mainly caused by severe burns. Curcuma longa herbal products have several such antioxidants, anti-inflammatory, anti-cancer. The purpose of this study was to find out the phytochemical content and effect of turmeric Ethanol Extract Ointment (Curcuma longa Linn) in curing grade II burns in Wistar rats (Rattus norvegicus). This study is an experimental study with a pre and post-test control group design approach. This research was conducted at Riwandi Pet Shop and Animal House and Laboratoirum Taxonomy of Plants, Department of Biology, Faculty of Mathematics and Natural Sciences (FMIPA), the University of North Sumatra in February-March 2021. The study sampled 20 turmeric rhizomes and male Wistar rats (Rattus norvegicus) divided into 4 treatment groups. Independent variables of topical formulation (base ointment, nebacetin ointment®, Turmeric Ethanol Extract Ointment (Curcuma longa) 5% and Turmeric Ethanol Extract Ointment (Curcuma longa) 10%, as well as independent variables that include wound contraction and epithelial period. The results of phytochemical screening in turmeric found phytochemicals in the form of flavonoids, alkaloids, and tannins. The results of the study obtained significant differences in the epithelial period of the standard group, turmeric ointment 5% and 10% against the control group. However, in the turmeric ointment group and the standard group, there was no difference in epithelialization periods. This is evident from the value P < 0.05 (Value P = 0.028). Where the wound contraction rate of turmeric ointment is 10% better than nebacetin ointment as standard. But in both turmeric ointments, both 5% and 10% and nebacetin ointment as standard did not show significant differences in the parameters of the epithelial period.
Analysis of Grade II Burns Healing from Andaliman Fruit Ethanol Extract Ointment (Zanthoxylum Acanthopodium Dc.) in Wistar Rats (Rattus Norvegicus) Li Sha; Florenly Florenly; Johannes Bastira Ginting; Fioni Fioni
Budapest International Research in Exact Sciences (BirEx) Journal Vol 3, No 4 (2021): Budapest International Research in Exact Sciences, October
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birex.v3i4.3054

Abstract

The prevalence of injuries has increased every year, from riskesdas results data in 2013 reported that burns are the sixth cause of accidental injuries with a prevalence of 0.7 percent of the Indonesian population. Andaliman fruit extract with various phytochemicals has active physiological activity as a potential antioxidant and antimicrobial. The study aims to explore the wound healing effects of andaliman fruit ethanol extract. This study was an experimental study using 20 rats divided into 4 groups (Control, Standard, Essential Oil 10%, and Essential Oil 15%). Wound healing parameters are assessed through wound contraction and epithelial period. Samples of andaliman fruit used in this study were obtained from one of the traditional markets in the city of Medan. Essential oils are obtained from the hydrodistillation process. The results of the study showed significant differences in the epithelial period of the standard group, 10% and 15% in the control group. However, in the andaliman ointment group and the standard group, there was no difference in the epithelial period. This is evident from the value P < 0.05 (Value P = 0.029). The conclusion of the healing effects of burns possessed by andaliman ointment both 10% and 15% and nebacetin ointment as standard shows a significant difference. Where the wound contraction rate of your ointment is 15% better than nebacetin ointment as standard. But in both andaliman ointments, both 10% and 15% and nebacetin ointment as standard did not show significant differences in the parameters of the epithelial period.
The Healing Analysis of II Degree Burn from Surgery Essential Oil Ointment (Curcuma Longa) in Wistar Rats (Rattus Norvegicus) Chen Wei; Florenly Florenly; Dewi Riastawaty Purba; Fioni Fioni
Budapest International Research in Exact Sciences (BirEx) Journal Vol 4, No 1 (2022): Budapest International Research in Exact Sciences, January
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birex.v4i1.3474

Abstract

Data in Indonesia the death rate from burns is still high at around 40%, mainly caused by severe burns. The most potential medicinal turmeric plant is its rhizome, which contains the phenolic compound curcumin and essential oils. Some of the benefits of turmeric antioxidants, anti-inflammatory, anti-cancer, acetylcholinesterase activity inhibitors, anti-fungal, and anti-bacterial. This study aims to find out the phytochemical content and effects of Turmeric Essential Oil Ointment (Curcuma longa Linn) in curing grade II burns in Wistar rats (Rattus norvegicus). This type of research is experimental with a pre-post approach and post-test control group design. The study was conducted at Riwandi Pet Shop and Animal House March-May 2021. The research sample is turmeric (Curcuma longa) obtained from a traditional market in the city of Medan and identified in herbarium Medanese (MEDA), Laboratoirum Taxonomy of Plants, Department of Biology, Faculty of Mathematics and Natural Sciences (FMIPA), University of North Sumatra, Medan. The test animal is a Wistar strain rat with as many as 20 tails divided into 4 treatment groups, so each group consists of 5 rats. The results of the study contained significant differences in the epithelial period of the standard group, 10% turmeric ointment and 15% against the control group. However, in the turmeric ointment group and the standard group, there was no difference in epithelialization periods. This is evident from the value P < 0.05 (Value P = 0.029). The healing effects of burns possessed by Turmeric ointment are both 10% and 15% and nebacetin ointment as standard shows significant differences. Where the wound contraction rate of turmeric ointment is 15% better than nebacetin ointment as standard. But in both turmeric ointments, both 10% and 15% and nebacetin ointment as standard did not show significant differences in the parameters of the epithelial period.
Analysis of Factors Related to the Risk of Hypertension Events at Royal Prima Medan Hospital in 2021 Li Wei; Florenly Florenly; Liena Liena; Fioni Fioni
Budapest International Research in Exact Sciences (BirEx) Journal Vol 3, No 4 (2021): Budapest International Research in Exact Sciences, October
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birex.v3i4.2660

Abstract

Hypertension is estimated to be the cause of death of 7.1 million people worldwide or about 13% of the total death. The purpose of the study is to find out the analysis of factors related to the risk of hypertension events. This type of quantitative research is a non-experimental descriptive approach. The study was conducted at Royal Prima Hospital, April-June 2021. The study population of all inpatients/street, Structural Equation Modelling (SEM) sampling technique sample numbered 200 people. Instrument research tension meter, stethoscope, digital scales, meter, and questionnaire. Bivariate (Chi-square) and multivariate (multiple logistic regression) analysis, 0.05 degree of confidence. The results of statistical tests using Chi-Square, the majority of respondents aged 56-65 years 124 people (62%), p-value 0,000, the majority of female respondents are 141 people (72%), p-value 0,000, the majority of respondents have a history of hypertension in the family of 161 people (81%), p-value 0,006, the majority of respondents do not smoke 146 people (73%), p-value 0,044, the majority of respondents dietary patterns rarely consume fat by 156 people (78%), p-value 0.026, the majority of respondents did not consume alcohol 171 people (86%), p- value 0.016, these variables had a meaningful relationship with p-value < 0.05. While the majority of obese respondents amounted to 138 people with a percentage (69%), had no association with p-value 0.117 (>0.05). In the results of multivariate analysis, the most dominant factor determining the incidence of hypertension is the sex variable, p-value (0.000) < 0.05, or value 21,200, meaning that the sex has a 21,200 chance of developing hypertension. Conclusions of research variables age, gender, family history, smoking, diet, alcohol consumption have an association with the incidence of hypertension, the most dominant factor is gender. It is expected that all communities can still maintain a healthy lifestyle, to avoid various diseases, especially non-communicable diseases.
The effect of gelagah stem extract on blood glucose levels in male white rats induced with alloxan Simatupang, Veronica Triwindari; Lubis, Asyrun Alkhairi; Nasution, Ali Napiah; Lumbantobing, Christina JRE; Fioni, Fioni; Rahimi, Armon
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 1 (2024): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i1.5218

Abstract

Diabetes mellitus is a metabolic disorder characterized by elevated blood glucose levels due to insulin deficiency, insulin resistance, or both. This study aimed to investigate the effects of gelagah stem extract (Saccharum spontaneum L.) on blood glucose levels in male Sprague-Dawley rats induced with alloxan. Experimental rats were divided into six groups: a normal control group, a negative control group (administered 100 mg/kg body weight alloxan), a positive control group (administered 5 mg/kg body weight glibenclamide), and three treatment groups administered gelagah stem extract at doses of 100, 200, and 400 mg/kg body weight. Results showed that all doses of gelagah stem extract significantly reduced blood glucose levels in alloxan-induced diabetic rats. Statistical analysis (Post hoc LSD) confirmed that the decrease in blood glucose levels was significantly different between the treatment groups and the negative control group (p < 0.05).
Analisis kadar zat besi pada sari kedelai kemasan dengan metode spektrofotometri UV-VIS br Karo, Reh Malem; Sinurat, Jhon Patar; Fioni, Fioni; Fibrini, Dewi
Jurnal Prima Medika Sains Vol. 3 No. 2 (2021): Desember
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v3i2.2038

Abstract

Latar belakang: Kedelai adalah hasil pangan jenis kacang-kacangan yang sangat kaya akan nutrisi yang bermanfaat bagi kesehatan manusia. Tujuan: Untuk mengetahui keberadaan zat besi dan kadar zat besi dalam sari kedelai. Metode: Analisis kualitatif menggunakan pereaksi NaOH, K4[Fe(CN)6] dan K3[Fe(CN)6] dan analisis kuantitatif menggunakan spektrofotometer UV-Visibel pada panjang gelombang 248.3 nm. Hasil: Sari kedelai mengandung zat besi yang dibuktikan melalui analisis kualitatif menggunakan pereaksi NaOH, K4[Fe(CN)6] dan K3[Fe(CN)6] yang menghasilkan masing-masing endapan hijau, biru dan coklat yang artinya mengnadung zat besi. Persamaan regresi linear larutan standar besi adalah Y = 0.0154x  +  0.1555 dengan korelasi (R2) sebesar 0.9981. Kadar zat besi dalam sari kedelai adalah 56.48 mg/ml dan termasuk dalam kelompok produk yang memiliki kadar zat besi yang cukup tinggi. Kesimpulan: Sari kedelai mengandung zat zat besi dengan kadar sebesar 56.48mg/ml.
Co-Authors ARILYN, ERIKA JIMENA Aulia, Hilda Rafni Chen Wei Dewi Riastawaty Edy Fachrial Fibrini, Dewi Florenly Florenly Florenly Florenly Florenly Florenly Ji Junfeng Jiang Fan Johannes Bastira Ginting Khainir Akbar, Khainir Li Sha Li Wei Liana Liana Liena Liena Lister, I Nyoman Ehrich Lubis, Asyrun Alkhairi Lumbantobing, Christina JRE Nasution, Ali Napiah Rahimi, Armon Reh Malem br Karo Rizal Rizal Simatupang, Veronica Triwindari Sinurat, Jhon Patar WAHYU WIDOWATI Wienaldi, Wienaldi