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All Journal Jurnal Kedokteran Syiah Kuala Journal of Epidemiology and Public Health
Revi Gama Hatta Novika
Midwifery Study Program, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia
Health Professions Medicine & Pharmacology Public Health

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Effects of acetylcholinesterase inhibitor Donepezil on cognitive function and vital sign in patients with dementia Maria Yosita Ayu Hapsari; Fathu Thaariq Baihaqy; Muhana Fawwazy Ilyas; Pepi Budianto; Revi Gama Hatta Novika
Jurnal Kedokteran Syiah Kuala Vol 23, No 1: April 2023
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v23i1.27558

Abstract

The prevalence of people with dementia is increasing both in Indonesia and throughout the world. Donepezil is one of the dementia therapy options that has been shown to have benefits. This study aims to determine the relationship between the administration of donepezil with cognitive function and vital signs: systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) in patients with dementia. The research was conducted at Dr. Moewardi Hospital (RSDM), Surakarta, Indonesia from September 2021 to February 2022 using a quasi-experimental design with different designs: one-group pretest-posttest design and time-series design. This study followed people with dementia who were given donepezil for 20 weeks. The patient was given donepezil 5 mg daily and scheduled for evaluation by the neurologist every 4 weeks to check vital signs. Cognitive function examination was performed with Mini-Mental State Examination (MMSE) at initial (before drug administration) and final (after 20 weeks). The analytical test included: repeated measures Anova, Friedman alternative, and paired T-test. A total of 27 patients were included in this study. There was an association between the administration of donepezil with cognitive function in patients with dementia at the RSDM (p0.004). Meanwhile, there was no significant association between the administration of donepezil and vital sign parameters (SBP, DBP, and HR).
Global Research Trends on Preconception Care on the Infertility Prevention: A Bibliometric Study Revi Gama Hatta Novika; Atriany Nilam Sari; Siti Nurhidayati; Rufidah Maulina; Luluk Fajria Maulida; Nurul Jannatul Wahidah; Muhana Fawwazy Ilyas
Journal of Epidemiology and Public Health Vol. 10 No. 2 (2025)
Publisher : Masters Program in Public Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/jepublichealth.2025.10.02.12

Abstract

Background: Infertility affects approximately one in six individuals globally and remains a growing reproductive health concern, often linked to modifiable risk factors present before conception. Preconception care (PCC) has gained recognition as a preventive strategy, however the implementation of PCC at scale remains challenged and yet its research landscape in relation to infertility remains under-mapped.This study aimed to analyze global research trends on preconception care in the context of infertility prevention using bibliometric methods.Subjects and Method: A bibliometric analysis was conducted using the Scopus database, with data retrieved on May 12, 2024. The search strategy included terms related to PCC and infertility, yielding 486 eligible publications after screening. Included documents were English-language publications in final form, relevant to preconception care and infertility, and classified as articles, reviews, conference papers, or book materials. Analysis was performed using Scopus tools, Biblioshiny (R), and VOSviewer to examine publication trends, key contributors, and thematic evolution.Results: A total of 486 publications from 1991 to 2025 were identified, with an annual growth rate of 6.43%. Most documents were original articles (67.7%) and reviews (28.4%), authored by 2,529 contributors across 307 publication sources. Several national strategies have formalized PCC into broader public health policy to reduce disparities in pregnancy outcomes and unmet fertility needs, but there remains a critical gap in the global PCC research agenda, such as the heterogeneity in intervention protocols.Conclusion: Research on preconception care in the context of infertility prevention has expanded steadily. However, Future research should prioritize longitudinal and interventional studies, foster global collaboration, and align with broader reproductive justice goals to strengthen the evidence base. Ultimately, enhancing the visibility and implementation of PCC in both clinical and public health domains will be pivotal in addressing modifiable infertility risks and promoting equitable reproductive outcomes worldwide.
Co-Authors Arif Nur Muhammad Ansori Atriany Nilam Sari Budianto, Pepi Cinantya Dwi Jayanti Erindra Budi Cahyanto Fathu Thaariq Baihaqy Hafi Nurinasari Haris Nur Ashfi Arifa Luluk Fajria Maulida Maria Yosita Ayu Hapsari Maulina, Rufidah Muhana Fawwazy Ilyas Muhana Fawwazy Ilyas Nanda Yuli Rahmawati Nurul Jannatul Wahidah Siti Nurhidayati Soetrisno Soetrisno