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This Author published in this journals
All Journal Jurnal Sain Veteriner Journal of Economic, Bussines and Accounting (COSTING) Journal of Economics Research and Social Sciences Jurnal Ekonomi Efektif Journals of Economics and Business
Monica Septiani
Fakultas Kedokteran Hewan UGM
Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Industrial & Manufacturing Engineering Veterinary

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Journal : Jurnal Sain Veteriner

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Histopathological and Immunohistochemical Evaluation of African Swine Fever Pigs in Bali Province Septiani, Monica; Juniantito, Vetnizah; Priosoeryanto, Bambang Pontjo
Jurnal Sain Veteriner Vol 42, No 3 (2024): Desember
Publisher : Faculty of Veterinary Medicine, Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jsv.98994

Abstract

African Swine Fever (ASF) is a disease affecting pigs, caused by a double-stranded DNA virus that is not transmissible to humans or other animals. It leads to significant economic losses due to high morbidity and mortality rates, particularly in densely populated pig regions like Bali Province. During the ASF outbreak from June to December 2023, this study conducted histopathological research on clinical samples. Biological materials from twelve pigs confirmed positive for ASF via qPCR examination were histopathologically analyzed. Tissue samples from various organs underwent processing and examination using hematoxylin and eosin staining. Immunohistochemistry (IHC) was employed to detect the ASF virus’s p54 protein. Clinical symptoms, anatomical pathology, and histological examination revealed characteristic acute ASF lesions. Immunohistochemistry consistently showed p54 viral antigen distribution in mononuclear cells/macrophages across various organs, with the spleen and lymph nodes being dominant sites in 12 pigs (100%). This comprehensive study demonstrates the effectiveness of IHC in detecting the ASF virus and characterizing its histopathology.Keywords: ASF; histopathology; immunohistochemistry
Co-Authors Ade Candra, Ade Bambang Pontjo Priosoeryanto Belinda, Arey Jessica Dwi Purwanti Efendi, Nandar Saputri, Hani Vetnizah Juniantito