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All Journal Majalah Kedokteran The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Devy Serevina
Unknown Affiliation
Medicine & Pharmacology

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Association between HBV DNA Level and Intrahepatic HBcAg Protein Expression of Hepatocytes in Patients with Chronic Hepatitis B Devy Serevina; Ening Krisnuhoni; Rino Alvani Gani
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 11, NUMBER 2, August 2010
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/112201079-82

Abstract

Background: Correlation between serum Hepatitis B viral deoxyribonucleic acid (HBV DNA) and hepatitis B core antigen (HBcAg) protein expression in the liver regarding hepatitis B e-antigen (HBeAg) status have not been well studied. This study was aimed to demonstrate association between serum HBV DNA and HBeAg levels with HBcAg expressions in the liver. Method: A total of 55 naive chronic hepatitis B (CHB) patients were enrolled. All samples were tested for HBeAg serum by serological test enzyme-linked immunosorbent assay (ELISA) and HBV DNA was determined by polymerase chain reaction (PCR) HBsAg and HBcAg were evaluated immunohistochemically in the liver tissue Results: Of 55 patients, 44 (80%) were HBeAg positive and 11 (20%) were HBeAg negative. There was a positive correlation between serum HBV DNA and HBcAg expression in the nuclei (r: 0.383; p = 0.004). There was association between HBcAg expression in the nucleus and qualitative HBeAg (p = 0.017). Conclusion: In the patient with chronic HBV, there is a very significant positive correlation between the level of viral replication and HBcAg expression in the nucleus of hepatocytes. Moreover, there is association between HBcAg expression in the hepatocytes nucleus and HBeAg serum level. These finding lead to the proposition that nucleus localization of HBcAg protein function to amplify the pool of cccDNA in the replication cycle of HBV.. Keywords: HBV DNA, Imunohistochemistry, HBcAg
Profil Pasien Kanker Serviks di RS Awal Bros Batam Tahun 2020–2022 Jenifer, Debora; Serevina, Devy; Nurprilinda, Marliana
Majalah Kedokteran UKI Vol. 39 No. 2 (2023): MEI - AGUSTUS
Publisher : Fakultas Kedokteran Universitas Kristen Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/mk.v39i2.5898

Abstract

Kanker serviks adalah keganasan leher rahim yang disebabkan oleh Human Papilomavirus tipe 16 dan 18 dan ditularkan melalui hubungan seksual. Indonesia merupakan negara dengan kasus kanker serviks terbanyak di Asia Tenggara. Tujuan penelitian ini untuk mengetahui profil pasien kanker serviks di RS Awal Bros Batam tahun 2020-2022. Penelitian ini bersifat retrospektif dengan mengambil data rekam medis pasien kanker serviks. Sebanyak 97 orang subjek yang diteliti memiliki rentang umur 36-50 tahun (55,7%), menikah (99%), paritas 3-4´ (52,6%), berpendidikan SMA (50,5%), ibu rumah tangga (74,2%). Keluhan utama adalah perdarahan yang ditemukan pada 52 subjek dengan gambaran histopatologi karsinoma sel skuamosa (72,2%) dengan diferensiasi baik (44,3%). Kata kunci: Human Papilomavirus, karsinoma sel skuamosa, paritas, derajat diferensiasi Cervical cancer is a malignancy of the cervix caused by Human Papillomavirus types 16 and 18 and is transmitted through sexual contact. Indonesia is the country with the most cases of cervical cancer in Southeast Asia. The aim of this research is to determine the profile of cervical cancer patients at Awal Bros Hospital, Batam in 2020-2022. This research is retrospective in nature by taking medical record data from cervical cancer patients. A total of 97 subjects studied had an age range of 36-50 years (55.7%), married (99%), parity 3-4 times (52.6%), high school education (50.5%), housewives (74.2%). The main complaint was bleeding which was found in 52 subjects with histopathological features of squamous cell carcinoma (72.2%) with good differentiation (44.3%). Keywords: Human Papiloma Virus, squamous cell carcinoma, parity, degree of differentiation
Co-Authors Ening Krisnuhoni Jenifer, Debora Nurprilinda, Marliana Rino Alvani Gani Rino Alvani Gani