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Agusdi Firdaus
Sekolah Tinggi Ilmu Farmasi (STIFARM) Padang
Medicine & Pharmacology

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Uji Efek Teratogen Ekstrak Etanol Daun Patikan Kebo (Euphorbia Hirta L.) Terhadap Fetus Mencit Putih Suhatri Suhatri; Agusdi Firdaus; Zet Rizal
Jurnal Farmasi Higea Vol 6, No 1 (2014)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (777.881 KB) | DOI: 10.52689/higea.v6i1.97

Abstract

Has done research about the teratogenic effects ethanol of extract test patikan Kebo leaves (Euphorbia hirta L.) concerning to fetal white mice. Animal experiments were grouped into 4 groups consisting of group I as  negative control given only 0.5% suspension of Na CMC, group II, group III and group IV was given the ethanol extract of patikan kebo leaves with variations dose of 25 mg / kg BW, 50 mg / kg BW, and 100 mg / kg BW once a day from day 6 to day 15 of pregnancy. 18th day of pregnancy mice dilaparaktomi. Dose of 25 mg / kg BW, dose of 50 mg / kg BW did not cause teratogenic effects. Teratogenic effect was found at dose of 100 mg/kg BW there was the discovery of defects cleft palate. The results showed the ethanol extract of patikan kebo leaves not affected weight gain parent mice were significantly (p> 0.05) when compared to the negative control. Amount of fetuses were significantly reduced (p <0.05) when compared to the negative control. Fetal weight showed no significant effect (p> 0.05) if compared with negative controls.
Co-Authors Suhatri Suhatri Zet Rizal