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All Journal Acta Pharmaciae Indonesia : Acta Pharm Indo
Wahida Hajrin
Department of Pharmacy, Faculty of Medicine, Mataram University, Indonesia
Medicine & Pharmacology

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Formulasi Dan Uji Aktivitas Antiradikal Bebas Granul Effervescent Sari Buah Duwet (Syzygium cumini L.) Dengan Metode DPPH Afrah Baitunnisyah; Windah Anugrah Subaidah; Dyke Gita Wirasisya; Wahida Hajrin; Yohanes Juliantoni
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 9 No 1 (2021): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2021.9.1.3382

Abstract

Buah duwet diketahui memiliki aktivitas antioksidan namun pengunaan di masyarakat belum optimal sehingga perlu diformulasikan ke dalam sediaan farmasi yang lebih efektif. Tujuan penelitian ini adalah menguji aktivitas antiradikal bebas sari buah duwet kemudian diformulasi dalam bentuk sediaan granul effervescent dan menguji aktivitas antiradikal bebasnya. Metode pengujian aktivitas penghambat radikal bebas DPPH sari buah duwet menggunakan instrumen spektrofotometri UV-Vis. Formulasi granul effervescent sari buah duwet dibuat dengan metode granulasi basah, kemudian dilakukan pengujian aktivitas antiradikal bebas menggunakan metode DPPH. Hasil penelitian menunjukkan bahwa sari buah duwet memiliki nilai IC50 sebesar 168,266 µg/ml. Hasil evaluasi sifat fisik granul effervescent yang didapat yakni kadar air 5,46 ± 102%, waktu alir 33,02 ± 0,474 detik, sudut diam sebesar 30,95 , waktu larut 1 menit 35 detik ± 0,01 detik, dan pH 7. Berdasarkan penelitian ini disimpulkan bahwa sari buah duwet memiliki aktivitas antiradikal bebas yang sedang dan dapat diformulasi menjadi granul effervescent dengan hasil evaluasi sifat fisik yang baik, namun tidak memiliki aktivitas antiradikal bebas setelah diformulasi.
Optimasi Konsentrasi Vaselin Album dan Adeps Lanae pada Formulasi Sediaan Salep Ekstrak Etanol Daun Kersen (Muntingia calabura L.) Baiq Saomi Alfilaili; Wahida Hajrin; Yohanes Juliantoni
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 9 No 2 (2021): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2021.9.2.4084

Abstract

Cherry leaves (Muntingia calabura L.) contain secondary metabolites such as tannins, flavonoids, and saponins. This secondary metabolite compound functions as an antibacterial, especially Staphylococcus epidermidis bacteria that cause acne, so that it can be developed into a formula. One of the dosage forms that can be developed is the ointment dosage form. The choice of base concentration is very important because it can affect the physical properties and effectiveness of the preparation. The purpose of this study was to determine the optimum composition of the ethanol extract formula of cherry leaves with variations concentration of Vaseline album and adeps lanae, physical properties and level of acceptance of the consumer formula which was declared optimal. Cherry leaves were extracted by maceration method using ethanol 96% solvent. Determination of the optimum value was carried out using the Simplex Lattice Design method available in the Design Expert software Version 11. The results showed that the optimum ointment formula had a composition of vaseline albumin and adeps lanae of 73,29% and 9,71%, with a spreadability 3,10 ± 0,12 cm, adhesion 6,10 ± 0,53 seconds, pH 4,78 ± 0,08, and the acceptability value is 4,02. So it can be concluded that the formula declared optimum has physical properties that meet the requirements and are liked by the respondents.
Variasi Metode Ekstraksi dan Penetapan Nilai SPF Ekstrak Rumput Laut Merah (Eucheuma cottonii) Yuyun Ramdani; Agus Dwi Ananto; Wahida Hajrin
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 9 No 1 (2021): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2021.9.1.4001

Abstract

Rumput laut merah (Eucheuma cottonii) memiliki kemampuan tabir surya dalam melindungi kulit dari paparan sinar matahari yang ditunjukkan oleh nilai SPF (Sun Protective Factor). Kandungan senyawa rumput laut merah dapat dipengaruhi oleh metode ekstraksi. Penelitian ini bertujuan untuk menentukan metode ekstraksi yang optimal agar diperoleh nilai SPF paling tinggi yang digunakan sebagai bahan aktif sediaan lotion serta melakukan evaluasi sifat fisik sediaan lotion. Metode ekstraksi yang dilakukan pada penelitian ini yaitu maserasi, soxhletasi, dan sonikasi. Penentuan nilai SPF dilakukan menggunakan spektrofotometri UV-Vis. Data diolah secara kuantitatif dengan analisis statistik SPSS dan hasil evaluasi sediaan lotion dianalisis secara deskriptif. Hasil penelitian diperoleh rendemen ekstrak maserasi, soxhletasi dan sonikasi secara berturut-turut yaitu 41,96%, 17,11%, dan 33,26%. Hasil nilai SPF ekstrak maserasi, soxhletasi, dan sonikasi dengan konsentrasi 20.000 ppm secara berturut-turut yaitu 31,147; 16,817; dan 17,908. Berdasarkan hasil uji statistik menunjukkan nilai SPF ekstrak maserasi berbeda signifikan dengan nilai SPF ekstrak sonikasi dan soxhletasi. Hasil tersebut menunjukkan bahwa metode ekstraksi mempengaruhi aktivitas tabir surya rumput laut merah. Hasil sifat fisik dari sediaan lotion yaitu berwarna putih keabuan, aroma lilin dengan sedikit aroma khas rumput laut, pH 6,67, daya sebar 5,16, daya lekat 1,06 detik serta sediaan yang homogen. Hasil SPF sediaan lotion diperoleh 6,010 dengan tipe proteksi ekstra.
Solvent optimization in moringa leaves' flavonoids extraction using simplex lattice design Siti Muhsonah Oktaviana; Wahida Hajrin; Nisa Isneni Hanifa
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 1 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.1.5271

Abstract

Background: Flavonoids found mainly as pharmacologically active natural ingredient of moringa (Moringa oleifera L.). Therefore, optimizing the solvent to maximize the levels of flavonoid components is needed. Objective: This study was conducted to determine the optimum solvent composition for extracting flavonoid compounds from moringa leaves using the simplex lattice design (SLD). Methods: Moringa leaves were extracted using the sonication method with five combinations of 96% ethanol and water as the solvent. The solvent composition was optimized using Design-Expert version 11 software. Moreover, UV-Vis spectrophotometry was used to screen and identify flavonoid content. Results: Flavonoids were detected in moringa extract. Using the F test, a valid SLD equation, y= 440,243(A) + 142,983(B) - 47,324(A)(B), was obtained. This equation shows that the solvent ethanol 96% : water (100:0) was the best solvent and produced the maximum amount of moringa flavonoid content, which was 440,2427 mg QE/g extract. Conclusion: The flavonoid content was directly proportional to the high composition of 96% ethanol.
Co-Authors Afrah Baitunnisyah Agus Dwi Ananto, Agus Baiq Saomi Alfilaili Dyke Gita Wirasisya Nisa Isneni Hanifa Siti Muhsonah Oktaviana Windah Anugrah Subaidah Yohanes Juliantoni Yuyun Ramdani