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All Journal JSFK (Jurnal Sains Farmasi & Klinis)
Annisa Nur Salasa
Fakultas Farmasi Universitas Andalas
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Uji Toksisitas Subkronis Ekstrak Etanol Tali Putri (Cassytha filiformis L.) Terhadap Fungsi Ginjal Tikus Yori Yuliandra; Armenia Armenia; Annisa Nur Salasa; Friardi Ismed
Jurnal Sains Farmasi & Klinis Vol 2, No 1 (2015): J Sains Farm Klin 2(1), November 2015
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (570.967 KB) | DOI: 10.29208/jsfk.2015.2.1.47

Abstract

Sub-chronic toxicity test of the deffated ethanolic extract of  tali putri (Cassytha filiformis L.) on the rat renal function has been carried out. A number of 16 male rats aged 2-3 months, weighing ±250 g were used as experimental animals. The rats were divided into 4 groups which consisted of 1 control group and 3 extract-treated groups given 1.25, 2.5, and 5 mg/kg extract administrated intraperitoneally once a day for 14 days. The creatinine clearance, renal function, and the ratio of renal were calculated and analyzed by two-way ANOVA followed by Duncan’s test. The study showed that the creatinine clearance and renal function decreased significantly during treatment (p<0.05). The kidney weight ratio of groups treated with extract, especially with greater doses, showed a very significant increase as compared with control (p<0,01). These indicated that the ethanolic extract of  C. filiformis on the doses of 1.25 – 5 mg/kg might decrease the renal function, althought it seemed to be relatively safe when used for 14 days.
Co-Authors Armenia, Armenia Friardi Ismed Yori Yuliandra