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Journal : Indonesian Journal of Multidisciplinary Science

Evaluation of the Influence of Risk Factors on the Time of Onset of Ulcers, Rest Pain, and New Gangrene Post-Angioplasty in Patients with Chronic Limb Threatening Ischemia (CLTI) at Dr. Cipto Mangunkusumo General Hospital Effendi, Haikal; Suhartono, Raden; Kekalih, Aria
Indonesian Journal of Multidisciplinary Science Vol. 4 No. 11 (2025): Indonesian Journal of Multidisciplinary Science
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/ijoms.v4i11.1178

Abstract

Chronic Limb Threatening Ischemia (CLTI) represents the end stage of peripheral arterial disease, characterized by rest pain, ulcers, and gangrene. This study aims to evaluate the influence of metabolic risk factors—namely diabetes mellitus (DM), chronic kidney disease (CKD), and hypertension—on the timing of new symptom onset. This study employed a retrospective observational design involving CLTI patients who underwent successful angioplasty at RSUPN Dr. Cipto Mangunkusumo. Clinical data and the onset time of symptoms were collected and analyzed using univariate, bivariate, and multivariate logistic regression analyses. The study revealed a high prevalence of diabetes mellitus (89.3%, with 56% uncontrolled), hypertension (77.3%, with 41.3% uncontrolled), and chronic kidney disease (32%). Post-angioplasty symptoms included gangrene (33.3%), rest pain (24%), combined rest pain and gangrene (24%), and ulcers (18.7%), with a mean onset time of 80 ± 105 days. Uncontrolled diabetes mellitus (p=0.001; mean 39.46 days), hypertension (p=0.006; mean 54.81 days), and chronic kidney disease (p=0.001; mean 29.58 days) were significantly associated with accelerated symptom onset. Multivariate regression analysis identified hypertension as the strongest predictor (p=0.021; B=59.234; ?=0.273), followed by DM (p=0.027; B=40.693; ?=0.249) and CKD (p=0.036; B=30.234; ?=0.226), collectively explaining 53.9% of the variation in onset time. Uncontrolled DM was associated with increased incidence of ulcers and gangrene; hypertension with combined rest pain and gangrene; while CKD was more frequently associated with rest pain. These findings highlight the importance of aggressive risk factor management and structured post-angioplasty monitoring to delay symptom onset and reduce complications.
The Correlation of Smoking and Coffee Consumption with Diabetic Foot Ulcer Using Wifi Criteria at Cut Meutia General Hospital, Lhokseumawe Syafruddin, Syafruddin; Suhartono, Raden; Sanyoto, Dhanasari Vidiawati
Indonesian Journal of Multidisciplinary Science Vol. 4 No. 12 (2025): Indonesian Journal of Multidisciplinary Science
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/ijoms.v4i12.1187

Abstract

Diabetic Foot Ulcer (DFU) is a serious complication of diabetes mellitus. Risk factors such as smoking habits and coffee consumption have been associated with poor glucose control and vascular dysfunction; however, their relationship to the severity of DFU is not yet fully understood. The severity of DFU wounds can be assessed using the clinically validated WIFI system (Wound, Ischemia, and Foot Infection). This research aims to evaluate the association between smoking habits and coffee consumption with the severity of DFU based on the WIFI score in patients at RSUD Cut Meutia, Aceh. This was a cross-sectional study involving 188 DFU patients who met the inclusion criteria. Statistical analysis was performed using the Chi-square test of independence. Results show a significant association was found between moderate smoking and DFU severity (p=0.002). Coffee consumption was not significantly associated with the severity of DFU (p=0.468). In multivariate analysis, no significant effect of smoking or coffee consumption on WIFI scores was found when analyzed simultaneously (p>0.05). Moderate smoking is associated with increased DFU severity, especially when combined with light or moderate coffee consumption. Coffee consumption alone did not show a meaningful relationship. The multivariate analysis did not reveal a significant simultaneous effect of both variables, suggesting the potential influence of other confounding factors on DFU severity.