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POTENSI EKSTRAK IKAN GABUS TERHADAP KESEMBUHAN LUKA DIABETES Bambang Prayugo; Muhammad Ichwan; Zulham Yamamoto
Jurnal Kedokteran Syiah Kuala Vol 21, No 2 (2021): Volume 21 Nomor 2 Agustus 2021
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v21i2.20376

Abstrak. Luka diabetes merupakan luka kronis yang berdampak buruk bagi morbiditas, mortalitas, dan psiko-sosio-ekonomi penderita maupun keluarganya. Kondisi hiperglikemia mengakibatkan fase penyembuhan luka tidak berjalan normal. Ekstrak ikan gabus, yang dapat diberikan peroral maupun sebagai bahan kombinasi penutup luka berpotensi terhadap penyembuhan luka diabetes melalui peningkatan jumlah netrofil dan makrofag, neovaskularisasi. Selain itu, ekstrak ikan gabus meningkatkan jumlah fibroblas, deposisi kolagen, peningkatan re-epitelisasi, kekuatan regangan, dan kontraksi pada penyembuhan luka.

Efek Antibakteri Kombinasi Ekstrak Daun Kelor (Moringa oleifera Lam.) dan Amoksisilin terhadap Staphylococcus aureus dan Escherichia coli secara In Vitro Setiadi Abdillah Pratama; Tri Widyawati; Muhammad Ichwan; Dian Dwi Wahyuni
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 1 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i1.1174

Staphylococcus aureus and Escherichia coli often infect humans and risky cause antibiotics resistance including amoxicillin. This encourages us finding alternative active ingredients: Moringa oleifera leaf. This study evaluated antibacterial activity of combination of Moringa leaf extract (KDK) and amoxicillin (KA) against S. aureus and E. coli in vitro. The research methods with true experimental research with post-test control group design. KDK obtained by maceration. Four concentrations of KDK test materials (20, 30, 40, 50%) and 1 concentration of KA (3 mg/mL). Disc diffusion test method taken and the parameter measured: the diameter of the disc inhibition zone. Data analyzed by One-way ANOVA and further Tukey’s test. KDK+KA against S. aureus (20.77±1.79 – 21.33±1.74 mm)>KDK (11.45±0.21 – 12.45±0.28 mm) or KA (14.50±0.42 mm). KDK+KA against E. coli (15.53±0.71 – 17.87±0.42 mm)>KDK (9.00±0.28 – 10.30±0.42 mm) or KA (13.45±0.35 mm). A significant (p<0.05) was obtained between the combination group (KDK+KA) versus a group (KDK or KA). The combination of Moringa leaf ethanol extract and amoxicillin synergistically effected as antibacterial against S. aureus and E. coli in vitro.

PENGARUH PEMBERIAN D-GALAKTOSA TERHADAP PERUBAHAN BERAT BADAN MENCIT JANTAN Indah Permata Sari; Muhammad Ichwan; Yahwardiah Siregar
JURNAL KEPERAWATAN DAN FISIOTERAPI (JKF) Vol 2 No 2 (2020): Jurnal Keperawatan dan Fisioterapi (JKF)
Publisher : Fakultas Keperawatan dan Fisioterapi Institut Kesehatan Medistra Lubuk Pakam

D-galactose is aldohexose which occurs naturally in the body, including in the brain which is found in lactose disaccharides in honey, beets and milk products. Needed in the body for lactose formation during the process of lactogenesis. Provision of large amounts of D-galactose can cause oxidative damage to various tissues and organs. The purpose was to see changes in body weight in male rats after being given a D-galactose injection. Samples using male mice aged 8 weeks with a weight of Â± 30 grams, the number of samples was 6 mice swiss webster strain. intra-peritoneal injection of D-galactose is given for 6 weeks every day (150 mg / kg / bb). The results of this study indicate that the statistical analysis is significant p <0.05 (p = 0.016). The conclusion after being given injection of D-galactose for 6 weeks every day intra peritoneally was found D-galactose had an effect on the weight gain of male mice.

EFEK LATIHAN FISIK TERHADAP KADAR MALONDIALDEHID PADA HEWAN MODEL PENUAAN Indah Permata Sari1; Muhammad Ichwan; Yahwardiah Siregar
Jurnal Endurance Vol. 6 No. 1 (2021): Jurnal Endurance : Kajian Ilmiah Problema Kesehatan
Publisher : LLDIKTI Wilayah X

Aging is a natural process that is characterized by decreased function. In the aging process a decline in the ability of reactive oxygen species. This causes damage to the membrane lipids that cause a decrease in function of the body's organs. Lipid oxidation process in the membrane because free radicals produce lipid peroxidation such as malondialdehyde which is used as a marker of oxidative stress. Regular physical exercise can overcome the negative effects of oxidative stress. To conduct studies on aging, animal models are used. One of the animal models used is the aging induction model by giving D-galactose. Metabolites from d-galactose can induce aging by causing oxidative stress. The purpose of this study was to determine the effect of physical exercise on reducing malondialdehyde levels in an aging animal model induced by D-galactose. This research was experimental in-vivo with a post test only research design. The research sample of 8 weeks old swiss webster mice, consisted of 10 treatment groups. The results of studies on animal models of aging induced D-galactose on malondialdehyde levels after being treated for 6 weeks from the statistical results obtained p value ≥ 0.05 was not significant. However, there was a significant decrease in MDA levels in the D-galactose + physical exercise group

EFEK LATIHAN FISIK TERHADAP KADAR MALONDIALDEHID PADA HEWAN MODEL PENUAAN Indah Permata Sari1; Muhammad Ichwan; Yahwardiah Siregar
Jurnal Endurance Vol. 6 No. 1 (2021): Jurnal Endurance : Kajian Ilmiah Problema Kesehatan
Publisher : LLDIKTI Wilayah X

Aging is a natural process that is characterized by decreased function. In the aging process a decline in the ability of reactive oxygen species. This causes damage to the membrane lipids that cause a decrease in function of the body's organs. Lipid oxidation process in the membrane because free radicals produce lipid peroxidation such as malondialdehyde which is used as a marker of oxidative stress. Regular physical exercise can overcome the negative effects of oxidative stress. To conduct studies on aging, animal models are used. One of the animal models used is the aging induction model by giving D-galactose. Metabolites from d-galactose can induce aging by causing oxidative stress. The purpose of this study was to determine the effect of physical exercise on reducing malondialdehyde levels in an aging animal model induced by D-galactose. This research was experimental in-vivo with a post test only research design. The research sample of 8 weeks old swiss webster mice, consisted of 10 treatment groups. The results of studies on animal models of aging induced D-galactose on malondialdehyde levels after being treated for 6 weeks from the statistical results obtained p value ≥ 0.05 was not significant. However, there was a significant decrease in MDA levels in the D-galactose + physical exercise group

Pemberdayaan Teman Sebaya untuk Strategi Regulasi Emosi, Pencegahan Perilaku Berisiko, dan Pemahaman Kesehatan Reproduksi Remaja Vita Camellia; Khairunnisa Khairunnisa; Muhammad Ichwan; Farah Dhiba; Zulfendri Zulfendri; Dewi Gita
Indonesian Journal for Social Responsibility Vol. 8 No. 02 (2026): December 2026
Publisher : LPkM Universitas Bakrie

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36782/ijsr.v8i02.623

Achieving the goals of Indonesia Emas 2045 requires a high-quality generation that is productive, innovative, capable of building harmonious social relationships, possesses strong character, and demonstrates awareness of the relationship between humans and environmental sustainability. In line with the programs of the Tebing Tinggi Population Control and Family Planning Office, the Forum Genre and the Youth Information and Counseling Center (Pusat Informasi dan Konseling Remaja [PIK-R]) have implemented youth empowerment activities to prevent drug abuse and early marriage. Findings from the Focus Group Discussion (FGD) indicated that adolescents had limited knowledge of emotion regulation strategies and reproductive health and had never received related training. This condition became the basis for implementing this community service program. The program was conducted over two days. On the first day, 67 students from several public senior high schools participated in emotion dysregulation screening using the Emotion Regulation Questionnaire (ERQ), psychological distress screening using the Kessler Psychological Distress Scale (K10), and educational sessions on emotion regulation and reproductive health. On the second day, 33 female students who were members of the Forum Genre and PIK-R participated in training on identifying cognitive distortions and practicing mindfulness. The results showed that 38.81% of participants did not experience psychological distress, while the remainder experienced mild to severe psychological distress. In addition, 25 participants (37.31%) predominantly used cognitive reappraisal, whereas 42 participants (62.69%) predominantly used expressive suppression. Overall evaluation revealed high participant satisfaction, participants expressing their readiness to apply and disseminate the knowledge to their peers.

Identification of Microbiota Causing Bromhidrosis in the Axillary Putri Wahdiah Utama; Nelva Karmila Jusuf; Imam Budi Putra; Muhammad Ichwan; R. Lia Kusumawati
Indonesian Journal of Global Health Research Vol 7 No 1 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i1.4194

Bromhidrosis is a clinical condition defined by an uncomfortable or unpleasant body odor. Since the apocrine glands are only active during puberty, most bromhidrosis occurs in the apocrine glands in the armpit and occurs when apocrine gland secretions approach the skin's surface, where they undergo various biochemical reactions caused by the presence of microbiota in the axillary skin, resulting in odor in the axilla. This research aims to identify microbiota species in the axilla that can cause bromhidrosis. A laboratory experimental research design with purposive sampling is used in this study. In this study, 60 samples were collected from students aged 15 to 18 years old at a high school in Medan, and the samples were analyzed at the University of North Sumatra Hospital's Microbiology Laboratory. All samples were taken from the right axillary skin swab, a Gram stain was performed, and the identified microbiota isolates were identified. The results of skin smear culture revealed a Gram-positive cocci group in 59 samples (98.3%) and a Gram-positive bacilli group in only one sample (1.7%). The microbiota responsible for bromhidrosis was identified as Staphylococcus hominis spp. hominins (30.4%), Staphylococcus epidermidis (27.8%), Staphylococcus aureus (16.5%), Kocuria kristinae and Staphylococcus haemolyticus (6.3%), Staphylococcus lugdunensis and Staphylococcus saprophyticus. The most common microbiota that causes bromhidrosis in the axilla is Staphylococcis hominis spp. Hominis, Staphylococcus epidermidis, and Staphylococcus aureus.

Efficacy of Combined Channa Striata and Curcumin Supplementation to Enhance Quality of Life among NSCLC Patients Undergoing Chemotherapy: A Randomized, Double-Blind, Controlled Trial Ammayasyiro Uzhma; Noni Noviasari Soeroso; Setia Putra Tarigan; Muhammad Ichwan; Taufik Ashar; Guntur Berlian; Asep Aripin
Indonesian Journal of Global Health Research Vol. 8 No. 5 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i5.2184

Chemotherapy remains a cornerstone treatment for non-small cell lung cancer (NSCLC), but treatment-related toxicities frequently contribute to nutritional deterioration and impaired quality of life (QoL). Nutritional supplementation may help support patients during treatment. This study evaluated the efficacy of combined Channa striata extract and Curcumin supplementation in improving health-related quality of life among patients with NSCLC undergoing chemotherapy. This study aimed to assess the effects of combined Channa striata extract and Curcumin supplementation on changes in health-related quality of life among patients with non–small cell lung cancer receiving chemotherapy. A randomized, double-blind, placebo-controlled trial was conducted among newly diagnosed NSCLC patients receiving chemotherapy. Participants were randomly assigned to receive either a combination of Channa striata extract and Curcumin (Striatamin®, PT Mega Medica) or placebo during two chemotherapy cycles. Quality of life was assessed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) at baseline and after treatment. Thirty-two patients were enrolled, with 16 patients in each group. On the EORTC QLQ-C30 functional scale, social functioning improved significantly in the intervention group compared with the control group after the second chemotherapy cycle (45.06 ± 25.65 vs. 33.33, p = 0.049). The intervention group also demonstrated a significantly greater improvement in global health status than the control group (12.49 ± 12.57 vs. 8.27, p = 0.041). Although numerical improvements were observed in several symptom domains, no significant differences were found between groups on the symptom scale (p > 0.05). Administration of a combination of Channa striata and Curcumin up to the second chemotherapy cycle was shown to improve quality of life, particularly in the social functioning domain, and to significantly enhance overall health in patients with NSCLC.

Association between Adherence to Secondary Prophylaxis and the Severity of Valvular Heart Disease in Children with Rheumatic Heart Disease Ressa Hana Peranginangin; Tina Christina Lumban Tobing; Fathia Meirina; Muhammad Ichwan; Rizky Adriansyah; Gema Nazri Yani
Indonesian Journal of Global Health Research Vol. 8 No. 5 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i5.2428

Rheumatic heart disease (RHD) is a complication of acute rheumatic fever that can cause progressive damage to the heart valves. Secondary prophylaxis is given to prevent recurrence of rheumatic fever and slow the progression of valve damage. However, the relationship between adherence to secondary prophylaxis and heart valve disease in children with RHD remains unclear. To determine the relationship between adherence to secondary prophylaxis medication use and the severity of heart valve disease in children with RHD. This study used a retrospective cohort design conducted at Haji Adam Malik General Hospital, Medan. Subjects were pediatric patients aged <18 years with a diagnosis of RHD who visited the Pediatric Heart Clinic between June and December 2025, had undergone routine secondary prophylaxis therapy for at least one year, and had complete echocardiographic data. Patients with congenital heart defects or other heart diseases were excluded. Data were obtained from patient registries and medical records, including age, gender, age at diagnosis, initial echocardiography results, adherence to secondary prophylaxis medication, and the severity of valve abnormalities after one year of follow-up. Data were analyzed using statistical software using univariate and bivariate analyses with a significance level of p<0.05. The most common valve lesion was severe mitral regurgitation (57,4%), and the mitral valve was the most frequently involved valve in children with RHD. Adherence to secondary prophylaxis was quite good, with 61.7% of patients compliant and 38.3% non-compliant. The analysis showed that adherence to secondary prophylaxis medication was not significantly associated with changes in heart valve severity during one year of follow-up (p>0.05). Adherence to secondary prophylaxis did not significantly correlate with changes in heart valve severity in children with RHD, although most patients maintained stable valve conditions throughout the follow-up period.

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