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All Journal BALI MEDICAL JOURNAL (BMJ) Majalah Kedokteran Bandung Dentika Dental Journal Global Medical and Health Communication BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Buletin Farmatera Acta Biochimica Indonesiana SRIWIJAYA JOURNAL OF MEDICINE Jurnal Respirologi Indonesia Jurnal Keperawatan dan Fisioterapi (JKF) JURNAL FARMASIMED (JFM) Sumatera Medical Journal KLOROFIL: Jurnal Ilmu Biologi dan Terapan Jurnal Endurance: Kajian Ilmiah Problema Kesehatan

Yahwardiah Siregar

Department Of Biochemistry, Faculty Of Medicine, Universitas Sumatera Utara, Medan

Author-ID : 382021

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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HUBUNGAN KADAR TARTRAZIN DAN SENG (ZN) DALAM DARAH PADA ANAK PENDERITA DEFISIT PERHATIAN DAN GANGGUAN HIPERAKTIVITAS (ADHD) Batubara, Melvariani Syari; Siregar, Yahwardiah; Rusmarilin, Herla; Soviani, Sri; Febriani, Husnarika
BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Vol 4, No 1 (2017): Agustus
Publisher : Program Studi Biologi, Fakultas Biologi Universitas Medan Area

This research aims to study Tartrazine and Zinc (Zn) status in blood sample of Attention Deficit Hyperactivity Disorder (ADHD) children. Deductive research using the descriptive method through 3 stage, namely : 1. Taken of blood sample, 2. Analysis of Tartrazine status in blood sample was performed by using High Performance Liquid Chromatograpy (HPLC) method, and 3. Analysis of Zinc (Zn) status in blood sample were measurements by using Atomic Adsorbance Spectrophotometry (AAS) method. Data were analyzed using descriptive analysis techniques and Chi Square tests (X2) by Computer programs (SPSS 15). The result of the assessment of Tartrazine status in blood sample of ADHD children that had been was considered statistically highly significant a increase of the assessment of Tartrazine status in blood sample of ADHD children by 130 mg/ml compared with laboratory reference (control) by 28 mg/ml, HA>C** (p<0,001). The result of the assessment of Zinc (Zn) status in blood sample of ADHD children that had been was showed statistically highly significant a reduce of the assessment of Zinc (Zn) status in blood sample of ADHD children by 0,37 Âµg/ml compared with laboratory reference (control) by 0,64-1,18 Âµg/ml, HA<C** (p<0,001). This was considered a reduction and increase in Tartrazine and Zinc (Zn) concentrations induces of the Hyperactivity children by 95%.

Hubungan Kadar Vitamin D Plasma dengan Indeks Mitosis pada Pasien Kanker Payudara Pratiwi, Astrid Siska; Siregar, Yahwardiah
Sriwijaya Journal of Medicine Vol. 1 No. 3 (2018): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (175.58 KB)

Breast cancer is the most common cancer suffered by women and one of the biggest causes of death for women worldwide. Later, nutrition became one of the risk factors in breast cancer outcome, one of them is vitamin D. Calcitriol is the active form of vitamin D as an anti-proliferation, and inhibits tumor growth. Uncontrolled proliferation is one of the characteristics of cancer cells. Tumor growth rates become prognostic markers that can be evaluated by correlating at cellular levels such as mitosis. The aimed of this study was to analyze the relationship between vitamin D levels and mitosis index in breast cancer patients. Research with cross sectional design gathered 50 breast cancer patients who were newly diagnosed and had never received chemotherapy. The study was conducted from January 2017 - August 2018 at the Department of Surgical Oncology, RSUPH. Adam Malik Medan. Examination of plasma vitamin D levels is done by ELISA technique at the Lab. Faculty of Medicine Universitas Sumatera Utara. The mitosis index data was obtained from the medical record of the research subjects reviewed by anatomical pathology specialists at the Lab. Anatomical Pathology of Faculty of Medicine Universitas Sumatera Utara. Statistical test uses Fisher Exact. The results of the study 48% of subjects had vitamin D sufficiency, 38% insufficiency and 14% had deficiency. The mean vitamin D levels in all of the study subjects were insufficiency (27.93ng / ml). In this study there was no significant relationship between plasma vitamin D levels and mitosis index in breast cancer patients p = 0.062. The insignificant relationship between vitamin D levels and mitotic index in this study shows that vitamin D not a single factors to influence the mitosis index in breast cancer patients.

SNP8NRG433E1006 NEUREGULIN-1 GENETIC VARIATION IN BATAKS ETHNIC WITH SCHIZOPHRENIA PARANOID AND HEALTHY CONTROL Effendy, Elmeida; Loebis, Bahagia; Amir, Nurmiati; Siregar, Yahwardiah
BALI MEDICAL JOURNAL Vol 3 No 2 (2014)
Publisher : BALI MEDICAL JOURNAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (332.257 KB)

The neuregulin 1 (NRG1) gene which influences the development of white matterconnectivity has been associated with schizophrenia. It influences neuronal migration, synaptogenesis,gliogenesis, neuron-glia communication, myelination, and neurotransmission in the brain and others.NRG1 is located in 8p13, and it is frequently replicated in schizphrenia. SNP8NRG433E1006 geneNRG1 is one of core at risk haplotype of schizphrenia. This study looked forward differencesSNP8NRG433E1006 neuregulin 1 between Bataks ethnic with schizophrenia paranoid and Bataksethnic healthy control. Methods: Batak ethnic with schizophrenia paranoid were recruited andinterviewed with semi-structured MINI ICD-X to establish the diagnosis. All the eligible subjectswere requested their permission for blood sampling. Healthy Batak ethnic were also recruited bymathcing the age and gender. The blood samples went through DNA isolation, Nested PCR, and DNAsequencing. Results: Ninety three subjects were recruited, but only 74 blood samples weresuccesfully sequenced. We found three types of polymorphisms, i.e. G/A allele at base pair (bp) 76,G/T allele at bp 112, and deletion at bp 110 in Batak ethnic with schizophrenia. There were two kindsequences at bp 113-116 in Batak ethnics, and Batak ethnics with ATCG were at higher risk forhaving schizophrenia. This study support that NRG1 is a schizophrenia-susceptibility gene.

ASPERGILLUS FUMIGATUS PADA SPUTUM PENDERITA BATUK KRONIK MENGGUNAKAN METODE PCR DAN KULTUR Thristy, Isra; Siregar, Yahwardiah
Majalah Kedokteran Bandung Vol 48, No 2 (2016)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Kecepatan tumbuh jamur yang bertambah pada manusia dapat terjadi akibat berbagai penggunaan obat-obatan, alat-alat kesehatan invasif, juga terdapat faktor predisposisi berupa penyakit kronik yang berat termasuk penyakit keganasan. Aspergilus fumigatus merupakan salah satu spesies jamur sistemik yang dapat menginfeksi manusia. Penggunaan polymerase chain reaction (PCR) untuk mendeteksi jamur merupakan diagnostik yang optimal. Tujuan penelitian ini adalah menganalisis Aspergillus fumigatus menggunakan PCR dan kultur pada sputum penderita batuk kronik. Penelitian ini menggunakan 51 sampel sputum penderita batuk kronik yang berasal dari Rumah Sakit Haji Adam Malik Medan, periode Mei 2012?Februari 2013 diteliti dengan metode deskriptif cross-sectional. Sputum diperiksa menggunakan metode PCR dan dilakukan kultur sebagai gold standard pemeriksaan jamur. Hasil penelitian dari 51 sampel didapatkan pemeriksaan PCR positif 35 sampel (69%) dan PCR negatif 16 sampel (31%). Pada hasil kultur dijumpai kultur positif 29 sampel (57%) dan kultur negatif 22 sampel (43%). Simpulan dari hasil penelitian ini adalah dari 51 sputum penderita batuk kronik ternyata 69% mengandung jamur Aspergillus fumigatus dan keadaan ini diperkuat dengan hasil kulturnya. Pemeriksaan PCR dapat dipergunakan sebagai salah satu pemeriksaan jamur yang cepat dan tepat. [MKB. 2016;48(2):78?83]Kata kunci: Aspergillus fumigatus, batuk kronis, kultur, PCRAspergillus Fumigatus in Sputum of Patients with Chronic Cough Using PCR and Culture MethodAbstractThe increasing prevalence of fungal growth in humans may occur as a result of the use of various drugs, invasive medical devices, and also the presence of predisposing factors like severe chronic diseases, including malignant disease. Aspergillus fumigatus is a systemic fungal species that can infect human beings. Polymerase chain reaction (PCR) is the most optimum diagnostic method to detect fungus. The purpose of this study was to analyze the presence of Aspergillus fumigatus by using PCR and culture method in sputum of patients with chronic cough. The sample of this study consisted of sputum from 51 patients who visited Haji Adam Malik Hospital in Medan. The examination applied the cross-sectional descriptive method. Sputum was examined using PCR and culture as the gold standard fungal examination. The results from the 51 samples showed that positive PCR results (69%) were found in 35 patients and negative results were found in 16 patients (31%). The culture results showed that positive cultures were seen in 29 samples (57%) and negative cultures were found in 22 samples (49%). it is concluded that from 51 patients with chronic cough sputum, 69% turn out to have Aspergillus fumigatus fungus and this result is reinforced by the culture results. PCR can be used as a quick and precise inspection method for detecting fungus. [MKB. 2016;48(2):78?83]Key words: Aspergillus fumigatus, chronic cough, culture, PCR

Correlation of ACE Gene Polymorphism and Hypertension in Stroke Ischemic Patients Chandra, Vincent Alexander; Siregar, Yahwardiah; Arina, Cut Aria
Sumatera Medical Journal Vol. 3 No. 1 (2020): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v3i1.3310

Stroke is the third highest cerebrovascular disease in the world with high mortality and disability rate that is mostly dominated by ischemic stroke. Genetic factor that had been reported to have an indirect effect in increasing the incidence of ischemic stroke is ACE gene polymorphism. ACE gene polymorphism is characterized by the insertion marked by letter (I) or deletion marked by letter (D) on intron 16, chromosome 17. ACE gene polymorphism has drawn a lot of attention from scientists and had been reported to have an indirect effect in increasing the ischemic stroke incidence through pathogenesis of hypertension and atherosclerosis. In this study, 78 subjects of ischemic stroke consist of 43 subjects with hypertension and 35 subjects with normotension. I allele of ACE gene polymorphism was more dominant than D allele in hypertensive ischemic stroke patients (72.1% > 27,9%) and this dominance was also seen in the incidence of hypertension vs normotension (55.4% > 44.6%). However, the correlation of ACE gene polymorphism with the incidence of hypertension was not statistically significant when compared based on its genotype (p=0.280) and allele (p=0.948).

Streptococcus mutans Antibacterial Activity of 0.1% Lysozyme Tooth Paste as an Alternative for Children Below 3 Years Old in Preventing Early Childhood Caries (ECC) (Experimental Laboratory Study): Aktivitas Antibakteri Streptococcus mutans dari Pasta Gigi Lisozim 0,1% Sebagai Alternatif Untuk Anak Di Bawah 3 Tahun Dalam Mencegah Karies Anak Usia Dini (PAUD) (Studi Laboratorium Eksperimental) Octiara, Essie; Sutadi, Heriandi; Siregar, Yahwardiah; Primasari, Ameta
Dentika: Dental Journal Vol. 24 No. 2 (2021): Dentika Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/dentika.v24i2.6401

One of many possible ways of preventing Early Childhood Caries (ECC) is by removing tooth debris. Fluoride tooth paste usage by children under 3 years old must follow recommended quantity, because of its possibility of being ingested which then might cause fluorosis. Lysozyme as an active element in a toothpaste is able to mediate bacterial aggregation and inhibit bacterial adhesion and also activate bacterial autolysin by destructing bacterial cell wall. This study aimed to compared Streptococcus mutans antimicrobial activity of non-fluoride lysozyme toothpaste of various concentration such as 0.025, 0.05, 0.1, and 0.2 %. This was an experimental research with post test only design. The tested tooth paste was lysozyme-contained with 0.025, 0.05, 0.1 and 0.2% concentrations. Children tooth paste containing fluoride, enzyme tooth paste and 0.2% chlorhexidine became the positive control. Test of S. mutans antibacterial activity used 3 methods: disc diffusion, well, and microtiter plate method. Analytical test used Anova one way with Bonferoni post hoc and p<0.05 significant level. The results showed that all concentrations of lysozyme tooth paste had inhibitory effect on the growth of S. mutans (p<0.05). The highest mean of S. mutans antibacterial activity in lysozyme tooth paste were on 0.1 and 0.2% concentrations. Conclusion stated that 0.1% concentration of lysozyme tooth paste can be used as an alternative tooth paste for children under 3 years old

PENGUKURAN KADAR PIRIDOKSIN (VITAMIN B6) DALAM DARAH PADA ANAK PENDERITA DEFISIT PERHATIAN DAN GANGGUAN HIPERAKTIVITAS (ADHD) Melvariani Syari Batubara; Yahwardiah Siregar; Herla Rusmarilin; Sri Soviani
KLOROFIL: Jurnal Ilmu Biologi dan Terapan Vol 2, No 1 (2018): Klorofil: Jurnal Ilmu Biologi dan Terapan
Publisher : Program Studi Biologi Fakultas Sains dan Teknologi Universitas Islam Negeri Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30821/kfl:jibt.v2i1.1801

This research aimed to study Piridoksin (Vitamin B6) status in blood sample of Attention Deficit Hyperactivity Disorder (ADHD) children. Deductive research using the descriptive method through 2 stage, namely : (1) Taken of blood sample, and (2) Analysis of Piridoksin (Vitamin B6) status in blood sample was performed by using High Performance Liquid Chromatograpy (HPLC) method. Data collected and assessed by once in one time. Data were analyzed using descriptive analysis techniques and Chi Square tests (X2) by Computer programs (SPSS 15). The result of the assessment of Piridoksin (Vitamin B6) status in blood sample of ADHD children that had been was considered statistically highly significant a reduce of the assessment of Piridoksin (Vitamin B6) status in blood sample of ADHD children by 0,422 ng/ml compared with laboratory reference (control) by 0,36-1,8 ng/ml, HA<C** (p<0,001). This was considered a reduction in Piridoksin (Vitamin B6)) concentrations induces of the Hyperactivity children by 95%.

HUBUNGAN KADAR TARTRAZIN DAN SENG (ZN) DALAM DARAH PADA ANAK PENDERITA DEFISIT PERHATIAN DAN GANGGUAN HIPERAKTIVITAS (ADHD) Melvariani Syari Batubara; Yahwardiah Siregar; Herla Rusmarilin; Sri Soviani; Husnarika Febriani
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol 4, No 1 (2017): Agustus
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/biolink.v4i1.960

This research aims to study Tartrazine and Zinc (Zn) status in blood sample of Attention Deficit Hyperactivity Disorder (ADHD) children. Deductive research using the descriptive method through 3 stage, namely : 1. Taken of blood sample, 2. Analysis of Tartrazine status in blood sample was performed by using High Performance Liquid Chromatograpy (HPLC) method, and 3. Analysis of Zinc (Zn) status in blood sample were measurements by using Atomic Adsorbance Spectrophotometry (AAS) method. Data were analyzed using descriptive analysis techniques and Chi Square tests (X2) by Computer programs (SPSS 15). The result of the assessment of Tartrazine status in blood sample of ADHD children that had been was considered statistically highly significant a increase of the assessment of Tartrazine status in blood sample of ADHD children by 130 mg/ml compared with laboratory reference (control) by 28 mg/ml, HA>C** (p<0,001). The result of the assessment of Zinc (Zn) status in blood sample of ADHD children that had been was showed statistically highly significant a reduce of the assessment of Zinc (Zn) status in blood sample of ADHD children by 0,37 µg/ml compared with laboratory reference (control) by 0,64-1,18 µg/ml, HA<C** (p<0,001). This was considered a reduction and increase in Tartrazine and Zinc (Zn) concentrations induces of the Hyperactivity children by 95%.

Pengaruh Pemberian Vitamin D terhadap Gambaran Foto Toraks pada Pasien Tuberkulosis Paru Beretnis Batak Debby Mirani Lubis; Yahwardiah Siregar; Bintang Y.M. Sinaga; Seri Rayani Bangun
Global Medical & Health Communication (GMHC) Vol 5, No 1 (2017)
Publisher : Universitas Islam Bandung

Tuberkulosis (TB) adalah penyakit menular yang sampai sekarang masih menjadi masalah kesehatan dunia. Vitamin D dapat berperan melawan bakteri Mycobacterium tuberculosis melalui mekanisme cathelicidin intraseluler. Penelitian ini bertujuan mengetahui pengaruh pemberian vitamin D terhadap perbaikan foto toraks pada pasien TB paru beretnis Batak. Sebanyak 42 pasien yang memenuhi kriteria inklusi diambil dari beberapa puskesmas di Kota Medan dan Kabupaten Deli Serdang selama bulan Januari–Juni 2016. Penelitian ini adalah penelitian analitik dengan desain eksperimental murni tersamar tunggal (single-blind randomized controlled trial). Pasien dibagi secara acak menjadi kelompok vitamin D dan kelompok plasebo. Kelompok vitamin D diberikan tablet vitamin D oral 100.000 IU (2,5 mg) sebanyak 4 kali pemberian (minggu ke-0, 2, 4, 6). Kedua kelompok diperiksa kadar vitamin D dan foto toraks sebelum dan sesudah pengobatan selama 8 minggu. Hasil penelitian menunjukkan bahwa kelompok dengan pemberian vitamin D menunjukkan kenaikan kadar vitamin D secara signifikan (p=0,00) dibanding dengan kelompok yang diberi plasebo (0,26). Tidak ada perbedaan yang bermakna pada perbaikan foto toraks (p=0,06) antara kelompok vitamin D dan plasebo, tetapi jumlah subjek yang mengalami perbaikan foto zona paru pada kelompok vitamin D lebih banyak dibanding dengan kelompok plasebo (2:1). Simpulan, pemberian vitamin D tidak memengaruhi perbaikan foto toraks pada pasien TB paru beretnis Batak.THE EFFECT OF VITAMIN D ON CHEST X-RAY PROFILE IN BATAK ETHNICITY PULMONARY TUBERCULOSIS PATIENTSTuberculosis is an infectious disease that is still a global health problem. Vitamin D may play a role in fighting the bacteria Mycobacterium tuberculosis through the mechanism of intracellular cathelicidin. This study aimed to determine the effect of vitamin D on the improvement of chest x-ray in patients with pulmonary tuberculosis from Batak ethnicity. As much as 42 patients who met the inclusion criteria taken from several clinics in Medan City and Deli Serdang District in January to June 2016. This is a analytical study using single-blind randomized controlled trial design. Patients divided into groups of vitamin D and placebo groups. Vitamin D group was given vitamin D tablet 100,000 IU (2.5 mg) orally 4 times (0, 2, 4, 6 weeks). Levels of vitamin D and chest x-ray before and after 8 weeks of treatment were examined. The results showed that group with vitamin D levels increased significantly (p=0.00) compared to the placebo group (0.26). There was no significant difference in the improvement of thoracic images (p=0.06) between group with vitamin D and placebo groups. However, the number of subjects who experienced improvement of lung zone images in the vitamin D group more than the placebo group (2:1). In conclusion, vitamin D does not affect the improvement of chest x-ray in patients with pulmonary tuberculosis from Batak ethnicity.

The Relationship between Tyr113His Epoxidized Hydrolase Enzyme Gene Polymorphisms and the Incidence of Smoking Lung Cancer Lucia Aktalina; Amira Permatasari Tarigan; Noni Novisari Soeroso; Yahwardiah Siregar; Ozar Sanuddin
Jurnal Respirologi Indonesia Vol 38, No 2 (2018)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v38i2.163

Background: This study aims to determine the relationship between the gene polymorphism of the enzyme Epoxid Hydrolase (EPHX) Tyr113His and the tendency of smokers to suffer from lung cancer. The EPHX Tyr113His gene polymorphism is a change in one nucleotide base of the EPHX gene to produce enzymes with decreased function by 50%. EPHX plays a role in the metabolism of chemical compounds in cigarette smoke, especially Benzo (a) Pyren (BaP), which becomes a carcinogen in the body. Methods: This study is a case-control study design conducted from October 2016 to February 2017. Venous blood was taken from 35 people with lung cancer at RSUP H Adam Malik Medan and 35 healthy smokers. The genotype examination of the EPHX gene was carried out using the PCR-RFLP method in the USU FK Integrated Laboratory. Results: The genotype frequency of heterozygous variant T/C and homozygous variant C/C in case groups was 83.3% and 16.7%, respectively. The frequency of the T allele in the case group was 41.67% and the C allele was 58.33%. Whereas in the control, the frequency was heterozygous variant T/C (80%) and homozygous variant C/C (20%). The frequency of the T allele in the control group was 40% and the C allele was 60%. There were no homozygous wildtype T/T genotypes in the two groups. There was no significant difference in the genetic distribution and allele distribution of the EPHX enzyme between case and control groups. Conclusion: There is no relationship between EPHX Tyr113His enzyme gene polymorphisms and the incidence of lung cancer in smoking. J Respir Indo 2018; 38(2): 93-9)

Co-Authors Ameta Primasari Ariyati Yosi Arrizal, Rizki Bahagia Loebis, Bahagia Bintang Y.M. Sinaga Bintang Y.M. Sinaga, Bintang Y.M. Bintang, Siti Sarah Bintang Sarah Blondina Marpaung Chandra, Vincent Alexander Cut Aria Arina Debby Mirani Lubis Donny Nauphar Elmeida Effendy Essie Octiara Febriani, Husnarika Hadyanto Lim Henny Erina Saurmauli Ompusunggu Heriandi Sutadi Herla Rusmarilin Herla Rusmarilin Herla Rusmarilin Husnarika Febriani Indah Permata Sari Indah Permata Sari1 Isra Thristy Jaminsen Sinaga Juwita -, Juwita Lucia Aktalina Melvariani Syari Batubara Miftahul Zannah Muhammad Amin Muhammad Ichwan Muhammad Ichwan Noni Novisari Soeroso Nurmiati Amir Oentari, Widyaningsih Ompusunggu, Henny E.S. Ozar Sanuddin Pardede, Sumondang M. Pratiwi, Astrid Siska Pratiwi, Astrid Siska Putri Chairani Eyanoer, Putri Chairani Rahmiwita, Rahmiwita Roesyanto-Mahadi, Irma D Sarah, Dewi Maya Seri Rayani Bangun Siregar, Kamal B. Sori M Sarumpaet, Sori M Soviani, Sri Sri Soviani Sri Soviani Syarifah Rahmatillah Tarigan, Amira Permatasari Umar Zein Wilson Arthur Zein

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