Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Grady Krisandi
Universitas Indonesia
Health Professions Medicine & Pharmacology Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
ANALISIS POTENSI TERAPI SELULER MENGGUNAKAN ADIPOSE-DERIVED STEM CELLS DAN PLATELET-RICH PLASMA DALAM PENANGANAN PENYAKIT ALZHEIMER Rejoel Mangasa Siagian; Grady Krisandi
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol 3, No 2 (2020): ALZHEIMER DAN STROKE ISKEMIK
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v3i2.4160

Abstract

Alzheimer sebagai penyakit penyebab utama dari kasus demensia pada lansia terus meningkat seiring dengan pertumbuhan jumlah penduduk usia lanjut. Diagnosis, pencegahan, dan secara khusus penanganan penyakit Alzheimer perlu diteliti lebih lanjut. Penelitian terapi seluler dengan menggunakan sel punca adipose-derived stem cell (ADSC) serta penggunaan bioteknologi platelet-rich plasma (PRP) menunjukkan sebuah penanganan dengan metode baru dan potensial oleh karennya dibutuhkan kajian analisis terkait potensi sebagai kandidat terapi Alzheimer. Kajian dilakukan sesuai dengan panduan PRISMA dari sejumlah database yang diakses daring. Dari hasil analisis studi literatur, ADSC dan PRP penurunan konsentrasi peptida amiloid beta (Aβ), pertumbuhan neuron dan sinaptogenesis, aktivasi mikroglia dengan fenotipe antiinflamasi, peningkatan produksi sitokin antiinflamasi, peningkatan stabilitas sinaps dan dendrit, peningkatan viabilitas neuron, peningkatan neurogenesis, dan penurunan neurodegenerasi.dan peningkatan kognitif. Potensi ADSC dan PRP cukup menjanjikan walaupun PRP masih belum banyak yang meneliti potensinya pada penyakit Alzheimer. Studi lebih lanjut mengenai kedua faktor bioaktif tersebut diperlukan untuk meningkatkan potensi serta kemungkinan kombinasi terapi ADSC dan PRP untuk penyakit Alzheimer.
POTENSI SENYAWA DERIVAT 2-AMINOIMIDAZOLE SEBAGAI AGEN AJUVAN TERHADAP INFEKSI MULTIDRUG-RESISTANT ACINETOBACTER BAUMANNII MELALUI SIFAT ANTIBIOFILM DAN RESENSITISASI ANTIBIOTIK Grady Krisandi; Aditya Parawangsa
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 3 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.3 Edisi September 20
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v8i3.229

Abstract

Background: Antibiotic resistance in hospital-acquired infection (HAI) is a big problem for healthcare. It becomes worse by the trend of antibiotic resistance that is more common in gram-negative bacteria. Acinetobacter baumannii is a gram-negative bacteria that causes HAI and is considered multidrug-resistant. This trend raises the need for an agent to resensitize antibiotics. 2-aminoimidazole found in sea sponges Leucetta and Clathrina and rich in Indonesian seas is a potential agent to resensitize antibiotics in A. baumannii. Methods: Literature searching worked using specific keywords in the search engine (Google and Google Scholar) and online databases (PubMed and SCOPUS). Twenty-three studies from various journals were retrieved. Discussion: 2-AI has various derivative compounds followed by pharmacophores. 2-Aminoimidazole triazole (2-AIT) is one of the potential derivates with antibiofilm character to resensitize Acinetobacter baumannii. Optimization of the tail group 2-AIT carries out by several methods such as simple organic chemical reactions and Suzuki-Miyaura cross-coupling. The optimized group works as an antibiofilm by binding to the bfmR protein, which plays a role in forming biofilms. The toxicity of this compound in the hemolysis test and C. elegans is relatively low. Conclusion: 2-AI has an antibiofilm activity that allows antibiotic diffusion in A. baumannii blocked by biofilm. This activity enables the resensitization of A. baumannii towards antibiotics. The safety of 2-AI has also been proven in vitro and in vivo. These findings conclude that 2-AI that extracted in sea sponges from Indonesian seas can be an agent to resensitize antibiotics in multidrug-resistant A. baumannii.
Co-Authors Aditya Parawangsa Rejoel Mangasa Siagian