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All Journal JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Majalah Farmaseutik
Fita Rahmawati
Departemen Farmakologi dan Farmasi Klinik, Fakultas Farmasi, Universitas Gadjah Mada
Health Professions Medicine & Pharmacology Public Health

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Uji Perbandingan Antibiotik Profilaksis Ceftriaxone versus Cefazolin pada Bedah Obstetri dan Ginekologi Asri Rahayu; Fita Rahmawati; Tri Murti Andayani; Ammar Siradjuddin
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 10, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.59779

Abstract

Surgical site infection (SSI) is the most common complication in postoperative surgical patients which is associated with high morbidity, mortality, and cost burden. These complications can be prevented by giving proper prophylactic antibiotics. Cefazolin is a recommended prophylactic antibiotic, but in the practice in Indonesia hospital, there are still many uses of ceftriaxone. This study aimed to compare the clinical outcome and safety of cefazolin and ceftriaxone as prophylactic antibiotics in preventing SSI in obstetric and gynecological surgical patients. The study design was double-blind randomized controlled trial. The data collection was conducted from January to June 2020 at dr. Dradjat Prawiranegara Regional Hospital Serang. A total of 82 subjects who met the inclusion criteria were divided into two groups by block randomization, 41 subjects were given cefazolin and 41 subjects were given ceftriaxone. The clinical outcome was measured by preventing SSI for the effectiveness and side effects for safety outcomes in both groups. The comparison of effectiveness and side effects were analyzed using the bivariate test (chi-square or fisher’s exact test) and relative risk (RR). The study showed that the effectiveness of cefazolin was the same as ceftriaxone in preventing SSI for 30 days (RR= 0.89; p= 0.724; 95%CI: 0,193-3,133) with the number of SSI 12.2% vs 9.8%. Side effects included nausea, vomiting, and phlebitis was observed in the administration of antibiotic by intravenous push (IVP) pre-operating.  Cefazolin have safetier than ceftriaxone with the incidence of side effects were 9.8% vs 29.3% ((RR = 0,33; p= 0.003; 95% CI: 0.076-0.895).  Cefazolin is an antibiotic recommended by Indonesian Ministry of Health and the Association of Obstetrics and Gynecology.  This study encourages the use of cefazolin to prevent resistance due to ceftriaxone to overuse.
Keamanan Penggunaan Antiglukolan pada Pasien Rawat Inap Stroke Iskemik dengan Atrial Fibrilasi Juniarto Mende; Fita Rahmawati; Ika Puspitasari
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 12, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.74893

Abstract

Atrial fibrillation can cause stroke due to blood stasis in the left atrium which triggers thrombus formation and embolization of the brain. Administration of anticoagulants is used to prevent clot formation to prevent the occurrence of stroke, but on the other hand, it is associated with the risk of bleeding side effects. This study aims to evaluate the safety of anticoagulants in ischemic stroke patients with atrial fibrillation. The study used a cross-sectional design. Retrospective data were taken from the medical records of RSUP Dr. Sardjito, Yogyakarta period January 2018 to December 2020. The research subjects were ischemic stroke patients with atrial fibrillation. Evaluation of the safety of anticoagulants includes the number of major and minor bleeding events in each type of anticoagulant and the factors that influence the occurrence of bleeding. A total of 70 patients met the study inclusion criteria. Bleeding occurred in 41 cases (58,57%). Major bleeding was 28 patients (40%) and minor bleeding was 13 patients (18,57%). The most common anticoagulant that causes bleeding is warfarin. Multivariate test of the factors that influence the occurrence of bleeding in kidney failure (OR = 5,990; 95% Cl 2,002-17,920; p = 0,001). Monitoring the side effects of anticoagulants, especially warfarin is necessary. Pharmacists can play an important role in monitoring and preventing bleeding events by taking into account risk factors, especially kidney failure.
Perbandingan Efektivitas Penggunaan Nifedipin Dengan Metildopa Dalam Mengontrol Tekanan Darah Pasien Preeklamsia Sara Septi Widayani; Fita Rahmawati; Nanang Munif Yasin
Majalah Farmaseutik Vol 18, No 3 (2022)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v18i3.64894

Abstract

Preeklamsia merupakan salah satu gangguan hipertensi selama kehamilan dimana salah satu tanda yang dialami oleh pasien adalah terjadinya peningkatan tekanan darah yang ditunjukkan dengan peningkatan tekanan darah sistolik ≥140 mmHg dan atau tekanan diastolik ≥90 mmHg. Belum banyak bukti yang menunjukkan pilihan terapi paling efektif bagi pasien preeklamsia untuk mengatasi hipertensi selama kehamilan. Tujuan dari penelitian ini adalah membandingkan efektivitas dan profil keamanan terapi antihipertensi yaitu nifedipin dengan metildopa pada pasien preeklamsia. Penelitian ini dilakukan menggunakan metode kohort retrospektif yang dilakukan di RSUD Tidar Magelang selama 3 bulan. Analisis statistik efektivitas diukur berdasarkan penurunan tekanan darah setelah penggunaan antihipertensi menggunakan independent t-test sementara profil keamanan diukur berdasarkan kejadian hipotensi setelah penggunaan antihipertensi. Pengukuran tekanan darah diamati selama 48 jam pasien menjalani rawat inap. Besar sampel penelitian ini adalah 56 dimana 34 pasien mendapat terapi nifedipin dan 22 pasien mendapat terapi metildopa. Hasil deskriptif karakteristik antara kedua kelompok menunjukkan tidak dapat perbedaan antara kelompok nifedipin maupun metildopa (p>0.05). Rata-rata tekanan darah sistolik setelah penggunaan nifedipin adalah 131.15±14.90 dan kelompok metildopa 130.23±12.42(p=0.952). Rata-rata tekanan darah diastolik setelah penggunaan nifedipin adalah 86.59±10.18 dan kelompok metildopa 85.14±7.92(p=0.738). Tidak terdapat perbedaan efektivitas dan profil keamanan pada pasien preeklamsia dengan pemberian nifedipin maupun metildopa.
Gambaran Kepatuhan Penggunaan Obat Antituberkulosis pada Pasien Tuberkulosis Paru di Puskesmas Pahandut Kota Palangkaraya Anna Singgih D.P. Priyaputranti; Fita Rahmawati; Nanang Munif Yasin
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 13, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.83777

Abstract

Tuberculosis is a communicable disease caused by Mycobacterium tuberculosis. Indonesia's health profile stated that the number of tuberculosis cases in 2021 was 397,377 cases, indicating an increase compared to 2020 of 351,936 cases. Medication adherence is crucial for the management of tuberculosis. Some failures of tuberculosis treatment are caused by non-adherence. Detection of medication adherence is important to help control tuberculosis. This study aimed to describe the medication adherence of antituberculosis drugs and the predictive factor among pulmonary tuberculosis of drug-susceptible tuberculosis. This study uses a cross-sectional design with retrospective data collection. Drug therapy monitoring and TB-01 form collected non-adherence identification from January to February 2023 at Puskesmas Pahandut, Palangkaraya city, which involved 35 patients. The predictive factor was identified by an interview with the patient, the treatment observers, and the chief tuberculosis programmer. Adherence was measured by medication left over at the visit. The results showed 24 (77%)  adherent patients and 8 (23%)  non-adherent patients. The predictive factor involved seven dimensions patient-centered (lack of motivation, forgetting to take medicine, unacknowledged information by public health care provider, confusion about how to take medicine), access factors, social and lack of role of the treatment observers. The improvement role of healthcare providers in public health centers and treatment observers is prominent in increasing patient adherence. 
Perbandingan Angka Kematian Terapi Antiviral Favipiravir dan Remdesivir pada Pasien COVID-19 Di RSUP Dr. Sardjito Yogyakarta Nova Satriyani; Fita Rahmawati; Tri Murti Andayani
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 12, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.77288

Abstract

Antiviral treatment for SARS-CoV2 (Severe Acute Respiratory Syndrome Coronavirus-2) is still being studied for its effectivity. The antivirals in the July 3, 2021 edition of the COVID-19 management guidelines, namely favipiravir and remdesivir, are used for moderate, severe and critical degrees. The study compares the mortality rate of COVID-19 patients taking the antivirals favipiravir and remdesivir. This research is a retrospective cohort study conducted at RSUP Dr. Sardjito Yogyakarta. The data was from the medical records of patients diagnosed with moderate, severe, and critical degrees of COVID-19 treated during the January-December 2021 period. Ninety-nine patients (50.8%) used favipiravir, while 97 patients (49.5%) used remdesivir. Chi-square analysis and multiple logistic regression were used to determine the relationship between research variables. Study subjects with the highest percentage of age 46-65 years (65%), male sex (54,6%), comorbid diabetes mellitus and hypertension (13,3%), severe degree of severity (60,7%), and viral load CT value ≤ 29 (80,1%), the patient went home alive (61,2%), and died (38,8%). The antivirals did not affect on mortality (p > 0,05). Further research is needed with the same characteristics of the two groups involving factors of degree severity of the disease, co-morbidity, and other medication therapy.
Co-Authors Ammar Siradjuddin Anna Singgih D.P. Priyaputranti Asri Rahayu Ika Puspitasari Juniarto Mende Nanang Munif Yasin Nova Satriyani Sara Septi Widayani Tri Murti Andayani