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All Journal Majalah Kedokteran Nusantara The Journal Of Medical School International Journal of Health and Pharmaceutical (IJHP)
Bungaran Sihombing
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Health Professions Medicine & Pharmacology Nursing Public Health

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Perubahan tingkat kekerasan ereksi pada pasien BPH paska pemberian α1A- adrenoreceptors antagonis di RSUP H. Adam Malik Medan Muhammad Eka Agusfansyah; Syah Mirsya Warli; Bungaran Sihombing
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 45, No 3 (2012): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Abstract

Background : Lower urinary tract infection (LUTS) at benign prostate hyperplasia (BPH) patient commonly followed by sexual dysfunction which include erectile dysfunction, at last study there was relation between LUTS/BPH and erectile dysfunction.1a-adrenoceptors antagonists (Tamsulosin) is very selective adrenoceptor •1 antagonist. These drugs block a adrenaceptor1a the prostate which further led to improvement of LUTS symptoms and also blocked the action of noradrenaline at the level1a receptors on smooth muscle of the corpus cavernosum to enhance and improve erectile function. The purpose of this study was to determine changes in the level of erection hardness in patients with BPH after administration •1a-adrenoceptors antagonists for 1 month.Methods : This research is an experimental study. Anamnesis directly performed on 50 subjects who met the inclusion criteria and did not meet the exclusion criteria. To assess the degree of erection hardness using a special instrument that used erection hardness score (EHS), where EHS is a diagram of the quality of erection hardness which consisted of grade 1 to 4. Patients will be assessed level of erection hardness using EHS before and after the intervention for 1 month with •1a-adrenoceptors antagonistsResult : Based on statistical analysis, after administration of •1a-adrenoceptors antagonists found there was a significant increase in the value of EHS compared with before intervention, with P value = 0.001 (• = 0.005 CI = 95%). 36 subjects with EHS 2 before intervention, 16 subjects turned into EHS 3 after the intervention. 13 subjects with EHS 3 before the intervention, after the intervention did not change the value of EHS. One subject with EHS 4 before intervention also did not change after the intervention.Conclusion : This study proved that •1a-adrenoceptors antagonists can improve erectile dysfunction in patients with BPH. Keywords : BPH; erectile dysfunction; •1a-adrenoceptors antagonists; LUTS; EHS
Antioxidant Activity Of Platelet Rich Plasma Wistar Rats With Dpph And Abts Test Wienaldi; I Nyoman Ehrich Lister; Bungaran Sihombing
International Journal of Health and Pharmaceutical (IJHP) Vol. 2 No. 1 (2022): February 2022
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (210.808 KB) | DOI: 10.51601/ijhp.v2i1.18

Abstract

Free radicals and reactive oxygen species (ROS) are the cause of diseases such as cancer, diabetes, cardiovascular and inflammatory. The presence of an increase in the number of free radicals and excess ROS production in the body can cause an imbalance of the immune system. Therefore, additional antioxidants are needed from outside the body. During this time there are several antioxidant synthesis drugs such as (Butyl Hydroxy Anisole) BHA and (Butyl Hydroxyl Toluene) BHT. But in its use, this drug causes side effects. Therefore, it is necessary to source antioxidants that have no side effects if consumed. PRP is a product produced from fresh whole blood that contains components of Red blood cells, White blood cells, Platelets, and Plasma. Plasma contains organic and inorganic molecules and ions wherein abundant conditions serve to transport other substances. To determine the ability of PRP as an antioxidant, fractionation, and bioactivity tests for free radical capture of 1,1-diphenyl-2-picrilhydrazil (DPPH) and color decay tests at 2,2'-azino-bis-[3-ethylbenzotiazolin sulfonate] (ABTS) in vivo.. Based on the results of this study, PRP has antioxidant activity that increases along with the decrease in THE concentration of PRP with an antioxidant activity value of 10.57% with the DPPH test and 5.85% with the ABTS test at the lowest concentration (6.25 μg / mL). IC50 averages 190.29 μg/mL with DPPH test and 126.60 μg/mL with the ABTS test. The results of this study are an indication that PRP can be used as a treatment therapy related to the anti-oxidant activity
Co-Authors I Nyoman Ehrich Lister Muhammad Eka Agusfansyah Warli, Syah Mirsya Wienaldi