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All Journal journal of internal medicine E-Jurnal Medika Udayana Jurnal Medika Hutama KESANS : International Journal of Health and Science Jurnal Sosial dan Sains
Ketut Suardamana
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Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Nursing Physics Public Health Veterinary

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ASOSIASI CARA PEMBERIAN OBAT DENGAN ONSET DAN DERAJAT KLINIS REAKSI HIPERSENSITIFITAS AKUT/ANAFILAKSIS PADA PENDERITA YANG DIRAWAT DI RSUP SANGLAH DENPASAR BALI Eka Imbawan, I GN; Suryana, Ketut; Suardamana, Ketut
journal of internal medicine Vol. 11, No. 3 September 2010
Publisher : journal of internal medicine

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Abstract

Acute hypersensitivity reaction/anaphylaxis is a post exposure acute reaction involving dermatologic system/mucosal and subcutaneous tissue; while anaphylaxis is an acute systemic reaction involving two or more organ systems (the skin/mucosa and subcutaneous tissue, respiratory system, cardiovascular system, gastrointestinal system). Drugs as allergens can trigger these reactions orally, parenteral, or topically (contact). Different modes of drug administration are known to relate with onset and degree of the resulting clinical features. We conduct a cross sectional study to determine the association between modes of drugs administration with onset and clinical degree in patients hospitalized at Sanglah General Hospital Denpasar. This study involved 205 patients with acute hypersensitivity reactions/anaphylaxis (105 male and 100 female). Mean age was 33.12 (12 ! 80) years, 131 persons (63.9%) were triggered by drugs, while 57 patients (27.8%) were triggered by food, 13 patients (6.3%) by insect sting, and 3 patients (1.5% ) by other allergens. Of 131 patients with drugs as the trigger, 108 patients (82.4%) were given orally, 22 patients (16.8%) were given parenterally and 1 patient (0.8%) was triggered via contact. The mean onset of an acute hypersensitivity reaction/anaphylaxis triggered by oral and parenteral drugs were 4.2 hours and 0.6 hours respectively (p < 0.01). We conclude that modes of drug administration are associated with the onset of symptoms, but not with the degree of clinical manifestation of acute hypersensitivity reaction/anaphylaxi
A LITERATURE REVIEW ( Imunodefisiensi Primer): Imunodefisiensi Primer IDA BAGUS ADITYA NUGRAHA; I WAYAN WAWAN; KETUT SUARDAMANA
Jurnal Medika Hutama Vol. 3 No. 03 April (2022): Jurnal Medika Hutama
Publisher : Yayasan Pendidikan Medika Indonesia

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Abstract

Primary immunodeficiency disorder (PID) refers to a heterogeneous group of over 130 disorders that result from defects in immune system development and/or function. PIDs are broadly classified as disorders of adaptive immunity (i.e., T-cell, B-cell or combined immunodeficiencies) or of innate immunity (e.g., phagocyte and complement disorders). Although the clinical manifestations of PIDs are highly variable, most disorders involve at least an increased susceptibility to infection. Early diagnosis and treatment are imperative for preventing significant disease-associated morbidity and, therefore, consultation with a clinical immunologist is essential. PIDs should be suspected in patients with: recurrent sinus or ear infections or pneumonias within a 1 year period; failure to thrive; poor response to prolonged use of antibiotics; persistent thrush or skin abscesses; or a family history of PID. Patients with multiple autoimmune diseases should also be evaluated. Diagnostic testing often involves lymphocyte proliferation assays, flow cytometry, measurement of serum immunoglobulin (Ig) levels, assessment of serum specific antibody titers in response to vaccine antigens, neutrophil function assays, stimulation assays for cytokine responses, and complement studies. The treatment of PIDs is complex and generally requires both supportive and definitive strategies. Ig replacement therapy is the mainstay of therapy for B-cell disorders, and is also an important supportive treatment for many patients with combined immunodeficiency disorders. The heterogeneous group of disorders involving the T-cell arm of the adaptive system, such as severe combined immunodeficiency (SCID), require immune reconstitution as soon as possible. The treatment of innate immunodeficiency disorders varies depending on the type of defect, but may involve antifungal and antibiotic prophylaxis, cytokine replacement, vaccinations and bone marrow transplantation.
Management of Anaphylactic Reactions in Patients Suspected of Kounis Syndrome with Severe Cardiovascular Disorders Aryawan Suryakusuma, Anton; Suardamana, Ketut
Jurnal KESANS : Kesehatan dan Sains Vol 3 No 6 (2024): KESANS: International Journal of Health and Science
Publisher : Rifa'Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54543/kesans.v3i6.282

Abstract

Kounis syndrome (KS) is a hypersensitivity coronary disorder induced by various conditions, drugs, environmental exposures, foods, and coronary stents. Allergic, hypersensitivity, anaphylactic and anaphylactoid reactions are associated with this syndrome. Vasospastic allergic angina, allergic myocardial infarction and stent thrombosis with occluding thrombus infiltrated by eosinophils and/or mast cells constitute are the three reported, so far, variants of this syndrome. Its etiology is continuously increasing. Kounis syndrome is a ubiquitous disease which represents a magnificent natural paradigm and nature’s own experiment in a final trigger pathway implicated in cases of coronary artery spasm and plaque rupture. These cells are not only present in the culprit region before plaque erosion or rupture but they release their contents just before an actual coronary event. Therefore, awareness of etiology, epidemiology, pathogenesis, and clinical manifestations seems to be important for its prognosis, diagnosis, treatment, prevention
- HUBUNGAN RASIO NEUTROFIL LIMFOSIT (NLR) TERHADAP DERAJAT DEMAM BERDARAH DENGUE DI INSTALASI RAWAT INAP RS ARI CANTI PERIODE APRIL 2022 – MEI 2023 mahayanti, kadek seri; Suardamana, Ketut
E-Jurnal Medika Udayana Vol 13 No 1 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i01.P02

Abstract

Dengue Hemorrhagic Fever is caused by dengue virus infection which can cause death and cause an outbreak. Neutrophil lymphocyte ratio (NLR) is one of the cheap laboratory parameters and can predict plasma leakage in the critical period of dengue hemorrhagic fever. This study aims to determine the profile of dengue hemorrhagic fever patients and the relationship between the neutrophil lymphocyte ratio and the degree of dengue hemorrhagic fever in patients treated at Ari Canti Hospital for the period April 2022 – May 2023. This research is a retrospective analytical study with a cross-sectional approach using secondary data from archives at the Ari Canti Hospital Inpatient Installation for the period April 2022-May 2023. Data collection in the form of gender, age, neutrophil lymphocyte ratio and degree of dengue hemorrhagic fever was carried out using the convenient purposive sampling method. This study shows that the highest age group is the 26-35-year age group 35.7%, the highest gender is male 55.3% with cases of dengue hemorrhagic fever without shock 89.2% and a neutrophil lymphocyte ratio (NLR) of >2 as much as 64.2%. The result of Mann Whitney non-parametric test, showed that p value <0.0001. There is a significant relationship between NLR and the degree of dengue hemorrhagic fever in patients hospitalized at Ari Canti Hospital in April 2022, May 2023. Keywords : dengue virus., dengue hemorrhagic fever., hospitalization., neutrophil lymphocyte ratio
HUBUNGAN KARAKTERISTIK PASIEN DENGAN DERAJAT KLINIS ASMA DI RUMAH SAKIT UMUM PUSAT SANGLAH DENPASAR Prabandari, Anak Agung Sagung Mirah; Suardamana, Ketut; Paramita Ayu, Nyoman
E-Jurnal Medika Udayana Vol 11 No 9 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i9.P14

Abstract

Asma merupakan penyakit tidak menular dengan kasus terbanyak pada anak-anak. Data mengenai karakteristik pasien asma di Indonesia telah banyak ditemukan, namun data hubungan karakteristik pasien tersebut terhadap derajat klinis asma masih jarang dilaporkan, padahal data ini penting untuk perencanaan penanganan dan pencegahan asma yang prevalensinya terus meningkat. Tujuan penelitian ini yaitu untuk mengetahui hubungan karakteristik pasien dengan derajat klinis asma di RSUP Sanglah Denpasar. Penelitian ini merupakan penelitian analitik cross sectional yang dilakukan di Rumah Sakit Umum Pusat (RSUP) Sanglah Denpasar. Sumber data adalah 81 rekam medis pasien asma periode Januari 2016 – Desember 2016. Variabel bebas adalah usia diagnosis, jenis kelamin, tempat tinggal, kegemukan, atopi, dan merokok, sedangkan variabel tergantung adalah derajat klinis asma meliputi intermiten dan persisten. Data dianalisis dengan menggunakan uji chi square. Hasil penelitian menunjukkan adanya hubungan signifikan antara kegemukan (OR=10,96; 95%CI=2,31-52,03; p=0,03), riwayat atopi (OR=6,66; 95%CI=1,39-31,34; p=0,017), dan onset anak-anak (OR=0,22; 95%CI=0,06-0,87; p= 0,03) dengan derajat klinis asma, sedangkan tidak ada hubungan signifikan antara jenis kelamin, tempat tinggal, dan merokok dengan derajat klinis asma. Kata Kunci: karakteristik pasien, asma, derajat klinis, RSUP Sanglah
Desensitisasi Cepat Sebagai Prosedur Induksi Toleransi Terhadap Alergen Basudewa, I Made; Suardamana, Ketut
Jurnal sosial dan sains Vol. 5 No. 7 (2025): Jurnal Sosial dan Sains
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/jurnalsosains.v5i7.32409

Abstract

Immediate hypersensitivity reactions are one of the leading causes of morbidity in the world. Immediate hypersensitivity reactions occur immediately following exposure to the antigen. This reaction can manifest as mild, such as itching, or severe, such as bronchospasm, shock, and death. Immediate hypersensitivity reactions are included in type 1 hypersensitivity reactions which are mediated by immunoglobulin E. In some cases, there are conditions where a patient must consume a known allergen, which is usually in the form of a drug due to an illness. This condition often occurs in patients with infections for whom there are no other antibiotic options or in patients with cardiovascular disorders who must take aspirin. Rapid desensitization is a modality that can be used to treat this condition. This procedure aims to induce tolerance to a known allergen. This procedure has several stages and must be carried out with close monitoring. The end result of this procedure is the induction of tolerance to allergens, so that these allergens can be safely used by patients. Several protocols have been issued to perform rapid desensitization. Existing protocols for rapid desensitization include rapid desensitization protocols to penicillin, co-trimoxazole and aspirin.
Co-Authors Aryawan Suryakusuma, Anton Basudewa, I Made I GN Eka Imbawan I Wayan Wawan Ida Bagus Aditya Nugraha Ketut Suryana mahayanti, kadek seri Nyoman Paramita Ayu Prabandari, Anak Agung Sagung Mirah