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All Journal Jurnal teknologi Kesehatan Borneo Jurnal EduHealth Jurnal Ilmu Kesehatan Masyarakat (The Public Health Science Journal)
Nurhayati Adnan
Unknown Affiliation
Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Faktor Risiko Hipertensi pada Penderita Diabetes Mellitus Tipe 2 Sara Sonnya Ayutthaya; Nurhayati Adnan
Jurnal Ilmu Kesehatan Masyarakat Vol 9 No 02 (2020): Jurnal Ilmu Kesehatan Masyarakat
Publisher : UIMA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33221/jikm.v9i02.512

Abstract

Penyakit komorbid Diabetes Melitus (DM) yang umum dan paling sering adalah hipertensi. DM dan hipertensi terdapat secara bersamaan pada 40%-60% penderita DM tipe 2. Tujuan penelitian ini adalah untuk mengetahui unmodifiable factors dan modifiable factors pada penderita DM tipe 2 sebagai faktor risiko hipertensi. Desain penelitian ini adalah cross sectional. Sampel penelitian adalah pasien DM tipe 2 yang berobat di poli penyakit dalam RSUD dr. Chasbullah Abdulmadjid Kota Bekasi pada tanggal 30 September-19 Oktober 2019 dengan total sampel sebanyak 292 responden. Unmodifiable factors meliputi gender, umur, pendidikan, status perkawinan, lama menderita DM, hereditas DM, hereditas hipertensi dan golongan darah. Sedangkan modifiable factors terdiri dari indeks massa tubuh, pekerjaan, aktifitas fisik dan merokok. Hipertensi adalah keadaan tekanan darah sistolik ≥ 140 mm Hg dan/atau tekanan darah diastolik ≥ 90 mm Hg. Analisis data dengan Cox regression menggunakan Stata versi 15. Persentase hipertensi pada penderita DM tipe 2 adalah 46,57%. Dari analisis multivariat faktor risiko hipertensi yang signifikan untuk unmodifiable factors adalah faktor umur > 50 tahun (Pv= 0,02; PR= 1,93) dan kelompok dengan hereditas DM yang berasal dari kakek/nenek (Pv= 0,04; PR= 1,86) dan orang tua (Pv= 0,04; PR= 1,54). Sedangkan dari modifiable factors, Indeks Massa Tubuh berat badan lebih (Pv= 0,01; PR=1,81) dan obesitas (Pv=0,02; PR=1,81), merupakan faktor risiko hipertensi yang signifikan. Disarankan agar terhadap pasien DM tipe 2 terutama bila disertai dengan berat badan berlebih atupun obesitas perlu diberikan informasi lengkap tentang faktor risiko hipertensi.
Diphtheria Outbreak in Serang City, Banten, Indonesia, 2024: Epidemiological Investigation and Response Nisa, Rini Fatihatun; Laila, Nenden Hikmah; Nurhayati Adnan
Jurnal teknologi Kesehatan Borneo Vol 5 No 2 (2024): Jurnal teknologi Kesehatan Borneo
Publisher : POLTEKKES KEMENKES PONTIANAK

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30602/jtkb.v5i2.354

Abstract

Diphtheria is an infectious disease and often causes outbreak. Despite a significant global decrease in diphtheria cases due to effective vaccines, there's still a risk transmission for individuals who unvaccinated or incompletely vaccinated. A positive culture for Corynebacterium diphtheriae was reported in a diphtheria suspect in Serang City and an outbreak investigation was carried out. This study aimed to investigate the outbreak, identify risk factors, and recommend control measures. Data were collected through interviews and field observations to close contacts consist of household contacts, neighbors and school and we reviewed immunization coverage from the Public Health Center. Based on the investigation, it was shown that a 6 years-old male with signs and symptoms of Fever, Sore Throat, Swollen Neck, Pseudomembrane, difficulty swallowing, mouth ulcers, cough and vomiting, and positive results for toxigenic corynebacterium diphtheriae var intermedius. Risk factors for transmission are low immunization coverage, high population density, and mobilization. No additional cases were identified, but some close contacts were at risk of transmission due to unvaccinated. We recommend implementing Outbreak Response Immunization (ORI) as a critical measure to interrupt transmission.
Elevated Inflammatory Markers in COVID-19 Patients in Relation to Symptom onset and Antiviral Therapy Options Kevin Dermawan; Nurhayati Adnan
Jurnal EduHealth Vol. 14 No. 04 (2023): Jurnal eduHealt, 2023, December
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The COVID-19 virus has become a terrible global pandemic and has even caused severe trauma for all citizens in the world. Even though the number of cases is starting to decline, mutations of this virus are still possible and management is important to prevent serious fatalities. CRP and D-dimer have been widely studied as good markers of COVID-19 inflammation, and their application can even be used as a predictor of symptom severity. The rapid replication of the virus makes starting antiviral therapy from the onset of infection very crucial. Many previous studies have associated a worse prognosis in patients who receive antiviral therapy more slowly. The choice of antiviral is also important in order to effectively reduce viral replication and reduce the patient's severity. This study aims to compare the onset of symptoms and the choice of antiviral therapy in relation to suppressing the increase in inflammatory markers, namely CRP and D-dimer. This study uses a retrospective cohort model with a simple random sampling method that collects data on patients with COVID-19 who underwent treatment at a private hospital in Tangerang during the period January – December 2021 with a complete examination of CRP and D-dimer at the time the patient first arrived and on the day of the birth. 5 treatments. Data collected included age, gender, history of hypertension, diabetes mellitus, antiviral therapy used, onset of symptoms when the patient came to the hospital and CRP and D-dimer lab values. All of this data was then analyzed bivariately using the paired T test or Wilcoxon test method to determine the statistical significance of the data. The number of research subjects was 84 patients with an average age of 45.20 ± 15.02 years. Of all the patients, 14 patients had severe symptoms and 2 of them died. The CRP value at the time the patient first arrived was found to be lower in patients who came with symptom onset ≤ 2 days compared to those with symptom onset > 2 days with values respectively 12.55 and 33.01 mg/L, P value = 0.005. The D-dimer values in the two groups were also significantly different with values of 379.68 and 720 ng/mL, P value = 0.005. Based on the symptom onset category, it was found that patients who received antiviral therapy with symptom onset ≤ 2 days were found to have no significant differences in CRP and D-dimer values between the first day and the 5th day of treatment. This shows the effectiveness of the therapy provided. However, the group of patients who received antiviral therapy after the onset of symptoms > 2 days had significantly higher CRP and D-dimer values. The CRP values for the first day and the 5th day were 33.00 and 42.66 with a P value = 0.008 and the D-dimer values were 720 and 835.03 with a P value = 0.0029. In selecting the antiviral used, it was found that the remdesivir group provided a better prognosis with CRP values of 31.30 (H-1) and 40.93 (H-5), P value = 0.39. However, the same as favipiravir there was still a significant increase in D-dimer. Thus, starting antiviral therapy early with symptom onset ≤ 2 days is better for patient prognosis. The therapy chosen can be assumed to be that remdesivir is more effective than favipir avir in suppressing the increase in inflammatory markers, namely CRP and D-dimer.
Co-Authors Kevin Dermawan Laila, Nenden Hikmah Nisa, Rini Fatihatun Sara Sonnya Ayutthaya