Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Journal of Indonesian Management
Rismaya Rismaya
Unknown Affiliation
Humanities Decision Sciences, Operations Research & Management Medicine & Pharmacology Social Sciences

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
STUDI HUBUNGAN KUANTITATIF STRUKTUR-AKTIVITAS, MOLECULAR DOCKING DAN EVALUASI IN VITRO BEBERAPA FLAVONOID TANAMAN SEBAGAI COX-2 INHIBITOR Dadan Suryasaputra; Rina Anugrah; Algi Ikhsan; Rismaya Rismaya
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 6 No. 1 (2019)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (594.384 KB) | DOI: 10.22236/farmasains.v6i1.2562

Abstract

Flavonoid merupakan senyawa turunan polifenol, yang memiliki aktivitas antiinflamasi dan dianggap sebagai kelompok baru antinflamasi dengan menghambat enzim COX-2, contohnya hesperidin, diosmin, dan ginkgetin. Penelitian ini bertujuan untuk mengetahui potensi beberapa flavonoid (luteolin, kaemferol, apigenin, kuersetin, kuersitrin, katekin, baikalein, rutin, dan mirisetin) sebagai inhibitor selektif COX-2 secara hubungan kuantitatif struktur aktivitas (HKSA), molecular docking dan potensinya terhadap enzim COX-2 secara in vitro. Flavonoid yang diprediksikan menggunakan HKSA memiliki aktivitas adalah rutin, quersitrin, mirisetin dan quersetin dengan nilai aktivitas log(1/IC50prediksi) berturut-turut 7.52 μM; 6.25 μM; 5.48 μM; dan 5.46 μM. Dari hasil uji molecular docking terhadap enzim COX-2 diperoleh 4 flavonoid potensial yaitu; mirisetin, kuersetin, catechin, and apigenin, dengan RMSD 0,2301 ± 0,0185 dan nilai ΔG-nya berturut-turut: -8.57; -8.34; -8.68; and -8.54 (kcal/mol). Ligan yang memiliki potensi terhadap reseptor target dilakukan pengujian aktivitas inhibisi COX-2 secara in vitro dilakukan dengan teknik ELISA yaitu rutin, quersetin dan mirisetin, dengan persen inhibisi 42,9%; 40,26%; 53,53% dan celecoxib sebagai pembanding dengan 57,32% inhibisi. Ketiga flavonoid ini berpotensi dikembangkan sebagai inhibitor COX-2.
Analysis of Procedures for Procurement of Imported Accessories Products at PT DUA MALAIKAT Adnen Bait Sabila; Imam Abdul Aziz; Hermawan Hermawan; Raka Imam Rachmawan; R. Arya Rahmadiyatmaka; Rismaya Rismaya; Reni Sulastri; Ricky Firmansyah
Journal of Indonesian Management Vol. 3 No. 2 (2023): June
Publisher : Penerbit Jurnal Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53697/jim.v3i2.1254

Abstract

This study aims to qualitatively analyze the import procurement procedure in Company PT. DUA MALAIKAT. The research method used is a case study by collecting data from interviews with five respondents involved in the import procurement process. The results show that the import procurement process in Company PT. DUA MALAIKAT consists of several stages, namely determining needs, searching for suppliers, negotiating prices and contracts, verifying suppliers, payment and delivery, quality inspection, as well as receiving and storing goods. This study also found several challenges in the import procurement process, such as difficulties in determining the quality of imported products and issues related to international trade regulations. Therefore, Company PT. DUA MALAIKAT needs to improve import procurement management and collaborate with international trade experts to ensure an effective and efficient import procurement procedure.
Co-Authors Adnen Bait Sabila Algi Ikhsan Dadan Suryasaputra Hermawan Hermawan Imam Abdul Aziz R. Arya Rahmadiyatmaka Raka Imam Rachmawan Reni Sulastri Ricky Firmansyah Rina Anugrah