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Ruri Eka Maryam Mulyaningsih
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THE EFFECT OF LEMON JUICE (Citrus limon) IN LIVER HISTOPATHOLOGIC APPEARANCE OF MALE MICE (Mus musculus L.) EXPOSED BY MONOSODIUM GLUTAMATE (MSG) Dela Destiani Aji; Ruri Eka Maryam Mulyaningsih; Ahmad Fariz MZZ
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: Excessive consumption of MSG can cause the formation of free radicals in the body. Continuous use of MSG will cause free radical accumulation and oxidative stress in the liver. An antioxidant is one of the substances that has an ability to eliminate free radicals and protect the liver from oxidative stress. Lemon is a fruit that has benefits as a natural antioxidant. This study aims to determine the effect of administering lemon juice on the histopathological appearance of the liver exposed by MSG.Methodology: This post-test only control group design experimental study used 30 male white mice which were randomly divided into five groups: NC group, C(-) group, D1 group, D2 group, and D3 group. After 7 days of adaptation and randomized grouping, the mice were treated differently based on their group. All groups, except the NC group, were exposed to 4mg/gBW dose of MSG orally for 14 days. On the 15th day, MSG exposure was stopped and after that D1 group, D2 group, and D3 group were given lemon juice with a dose of each group 3.33ml/kgBW, 6.67 ml/kgBW, 13.33 ml/kgBW. The lemon juice was given once a day for 14 days using the gastric sonde. Histopathology examination was analyzed by pathologist in Gunung Jati Hospital, Cirebon, IndonesiaResults: Significant differences of liver histopathology were obtained between the normal control group with the dose 3 group (p = 0.005), the normal control group with the dose 2 group (p = 0.019), the normal control group with the dose group (p = 0.019) and between the negative control groups with dose 3 group (p = 0.027). Dose 3 group has higher liver damage compared to a normal control group and negative control group characterized by the form of parenchymatous degeneration. Conclusion: Lemon juice has a negative effect on the histopathology appearance of male white mice’s (Mus musculus L.) liver exposed by monosodium glutamate (MSG). Further studies are needed to validate the effect of the active compound and toxicity of lemon juice and to reveal the precise mechanisms on how lemon juice affects the hepatocytes.
CORRELATION BETWEEN ANXIETY LEVEL AND SELF DIRECTED LEARNING READINESS (SDLR) WITH STUDENT PEFORMANCE IN PROBLEM BASED LEARNING (PBL) Nita Safitri; Uswatun Khasanah; Ruri Eka Maryam Mulyaningsih
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: The pattern of medical education in Indonesia has changed from teacher-centered learning to student-centered learning. This change has an impact on methods, learning activities, and learning achievements of medical students. Problem Based Learning (PBL) is one of the main learning methods used in the faculty of medicine. PBL is a learning method that requires students to play an active role and facilitate collaborative learning. Due to the change of learning method, new medical students experience a lot of stress from in doing Problem Based Learning such as anxiety and may affect their PBL results as can be evaluated using Self-Directed Learning Readiness (SDLR). There are very few studies found to date investigating this phenomenon.Aims: This research aims to see the correlation between anxiety level and SDLR with student’s performance participating in first-year PBL in the Musculoskeletal and Locomotory System block in the faculty of medicine Universitas Swadaya Gunung Jati Cirebon.Methods: This is a cross-sectional observational study with total sampling. The samples were recruited from 167 first-year 2018 intake students of the faculty of medicine Universitas Swadaya Gunung Jati. Zung Self Rating Anxiety Scale questionnaire is used to measure anxiety levels and the SDLR questionnaire is used to measure Self Directed Learning Readiness (SDLR).Results: The Spearman test showed a medium negative correlation value of -0.49 (p>0.05) for the level of anxiety. It means that there is no significant effect of anxiety on the PBL performance. In addition, it shows a weak positive correlation value of 0.196 (p <0.05) for SDLR (self-directed learning readiness) showing a significant influence on PBL performance.Conclusions: The level of anxiety does not significantly influence PBL performance while SDLR has a significant effect on PBL performance.
INHIBITORY OF SOURSOP LEAVES (Annona muricata L.) EXTRACT AGAINST Malassezia furfur GROWTH Rike Rizqilah; Dadan Ramadhan Apriyanto; Ruri Eka Maryam Mulyaningsih
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: Malassezia furfur in certain conditions can turn into a pathological phase, from the yeast phase to the mycelia phase that attacks the stratum corneum. Malassezia furfur is one of the causes of Pityriasis versicolor. The prevalence of pityriasis versicolor in Indonesia is quite high at around 40-50%.  Several studies suggested that soursop leaves (Annona muricata L.)  contains active substances with anti-fungal properties.  This study aims to determine the inhibition of soursop leaves (Annona muricata L.) extract against the growth of Malassezia furfur.Methods: This study was an experimental study with Post-test Only Control Group Design.  Malassezia furfur fungi is used as subject in this study and ethanol extract of soursop leaves as a natural antifungal against Malassezia furfur. The concentrations of extract tested were 100%, 80%, 60%, 30%. Miconazole 2% was used as a positive control while DMSO 10% was used a negative one. The result of the study was analyzed by descriptive analysis which showed by increasing average diameter of antifungal.Results: The results showed that soursop leaves (Annona muricata L.)  extract had inhibitory effect on the growth of Malassezia furfur fungi  at 100% concentration of 2.50 mm, 80% at 1.50 mm, 60% at 0.47 mm, 30%  concentration at 0.25 mm and positive control of 14.50 mm. While as negative control, no inhibition zones were formed on SDA media.Conclusion: Soursop leaves (Annona muricata L.)  extract can inhibit the growth of Malassezia furfur, but the formed inhibition zone is weak. Further research is needed to found the best type of antifungal metabolites to maximize antifungal effects.
THE CORRELATION OF EDUCATION AND SOCIAL ECONOMIC LEVELS WITH ANTIBIOTIC SELF-MEDICATION IN THE COMMUNITY OF CIREBON Tridaya Putri Handayani; Muhammad Duddy Satrianugraha; Witri Pratiwi; Ruri Eka Maryam Mulyaningsih
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: People in developing countries, like Indonesia, often conduct self-medication. One of the most common drugs used in self-medication is antibiotics. Antibiotics should be used with caution since it can cause antibiotic resistance and possible unwanted side effects of the drug. There are several factors that influence self-medication behavior such as education and socio-economic levels. This research aims to find the correlation between education and social economic levels with antibiotic self-medication in the community of Cirebon.Method: This study was an analytical survey with cross-sectional method. This study was conducted from December 2018 to February 2019. A total of 300 respondents were recruited as samples using consecutive sampling technique. The respondents were recruited from 5 different pharmacies from each sub-district in Cirebon City and a validated questionnaire were used to obtain data. The collected data are analyzed using the Spearman correlation test.Results: The results of this study show that there was a significant but weak positive correlation of education level (r=0.224, p=0.001) and socio-economic (r=0.210, p=0.001) with self-medication using antibiotics. Conclusion: There is a significant positive correlation between education and socio-economic levels with antibiotic self-medication.
Co-Authors Ahmad Fariz MZZ Apriyanto, Dadan Ramadhan Dela Destiani Aji Nita Safitri Rike Rizqilah RR. Ella Evrita Hestiandari Satrianugraha, Muhammad Duddy Tridaya Putri Handayani Witri Pratiwi