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All Journal Proceedings of the International Conference on Applied Science and Health Tunas Medika Jurnal Kedokteran & Kesehatan
Ruri Eka Maryam Mulyaningsih
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Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Nursing Public Health

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THE EFFECT OF LEMON JUICE (Citrus limon) IN LIVER HISTOPATHOLOGIC APPEARANCE OF MALE MICE (Mus musculus L.) EXPOSED BY MONOSODIUM GLUTAMATE (MSG) Dela Destiani Aji; Ruri Eka Maryam Mulyaningsih; Ahmad Fariz MZZ
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: Excessive consumption of MSG can cause the formation of free radicals in the body. Continuous use of MSG will cause free radical accumulation and oxidative stress in the liver. An antioxidant is one of the substances that has an ability to eliminate free radicals and protect the liver from oxidative stress. Lemon is a fruit that has benefits as a natural antioxidant. This study aims to determine the effect of administering lemon juice on the histopathological appearance of the liver exposed by MSG.Methodology: This post-test only control group design experimental study used 30 male white mice which were randomly divided into five groups: NC group, C(-) group, D1 group, D2 group, and D3 group. After 7 days of adaptation and randomized grouping, the mice were treated differently based on their group. All groups, except the NC group, were exposed to 4mg/gBW dose of MSG orally for 14 days. On the 15th day, MSG exposure was stopped and after that D1 group, D2 group, and D3 group were given lemon juice with a dose of each group 3.33ml/kgBW, 6.67 ml/kgBW, 13.33 ml/kgBW. The lemon juice was given once a day for 14 days using the gastric sonde. Histopathology examination was analyzed by pathologist in Gunung Jati Hospital, Cirebon, IndonesiaResults: Significant differences of liver histopathology were obtained between the normal control group with the dose 3 group (p = 0.005), the normal control group with the dose 2 group (p = 0.019), the normal control group with the dose group (p = 0.019) and between the negative control groups with dose 3 group (p = 0.027). Dose 3 group has higher liver damage compared to a normal control group and negative control group characterized by the form of parenchymatous degeneration. Conclusion: Lemon juice has a negative effect on the histopathology appearance of male white mice’s (Mus musculus L.) liver exposed by monosodium glutamate (MSG). Further studies are needed to validate the effect of the active compound and toxicity of lemon juice and to reveal the precise mechanisms on how lemon juice affects the hepatocytes.
CORRELATION BETWEEN ANXIETY LEVEL AND SELF DIRECTED LEARNING READINESS (SDLR) WITH STUDENT PEFORMANCE IN PROBLEM BASED LEARNING (PBL) Nita Safitri; Uswatun Khasanah; Ruri Eka Maryam Mulyaningsih
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: The pattern of medical education in Indonesia has changed from teacher-centered learning to student-centered learning. This change has an impact on methods, learning activities, and learning achievements of medical students. Problem Based Learning (PBL) is one of the main learning methods used in the faculty of medicine. PBL is a learning method that requires students to play an active role and facilitate collaborative learning. Due to the change of learning method, new medical students experience a lot of stress from in doing Problem Based Learning such as anxiety and may affect their PBL results as can be evaluated using Self-Directed Learning Readiness (SDLR). There are very few studies found to date investigating this phenomenon.Aims: This research aims to see the correlation between anxiety level and SDLR with student’s performance participating in first-year PBL in the Musculoskeletal and Locomotory System block in the faculty of medicine Universitas Swadaya Gunung Jati Cirebon.Methods: This is a cross-sectional observational study with total sampling. The samples were recruited from 167 first-year 2018 intake students of the faculty of medicine Universitas Swadaya Gunung Jati. Zung Self Rating Anxiety Scale questionnaire is used to measure anxiety levels and the SDLR questionnaire is used to measure Self Directed Learning Readiness (SDLR).Results: The Spearman test showed a medium negative correlation value of -0.49 (p>0.05) for the level of anxiety. It means that there is no significant effect of anxiety on the PBL performance. In addition, it shows a weak positive correlation value of 0.196 (p <0.05) for SDLR (self-directed learning readiness) showing a significant influence on PBL performance.Conclusions: The level of anxiety does not significantly influence PBL performance while SDLR has a significant effect on PBL performance.
INHIBITORY OF SOURSOP LEAVES (Annona muricata L.) EXTRACT AGAINST Malassezia furfur GROWTH Rike Rizqilah; Dadan Ramadhan Apriyanto; Ruri Eka Maryam Mulyaningsih
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: Malassezia furfur in certain conditions can turn into a pathological phase, from the yeast phase to the mycelia phase that attacks the stratum corneum. Malassezia furfur is one of the causes of Pityriasis versicolor. The prevalence of pityriasis versicolor in Indonesia is quite high at around 40-50%.  Several studies suggested that soursop leaves (Annona muricata L.)  contains active substances with anti-fungal properties.  This study aims to determine the inhibition of soursop leaves (Annona muricata L.) extract against the growth of Malassezia furfur.Methods: This study was an experimental study with Post-test Only Control Group Design.  Malassezia furfur fungi is used as subject in this study and ethanol extract of soursop leaves as a natural antifungal against Malassezia furfur. The concentrations of extract tested were 100%, 80%, 60%, 30%. Miconazole 2% was used as a positive control while DMSO 10% was used a negative one. The result of the study was analyzed by descriptive analysis which showed by increasing average diameter of antifungal.Results: The results showed that soursop leaves (Annona muricata L.)  extract had inhibitory effect on the growth of Malassezia furfur fungi  at 100% concentration of 2.50 mm, 80% at 1.50 mm, 60% at 0.47 mm, 30%  concentration at 0.25 mm and positive control of 14.50 mm. While as negative control, no inhibition zones were formed on SDA media.Conclusion: Soursop leaves (Annona muricata L.)  extract can inhibit the growth of Malassezia furfur, but the formed inhibition zone is weak. Further research is needed to found the best type of antifungal metabolites to maximize antifungal effects.
THE CORRELATION OF EDUCATION AND SOCIAL ECONOMIC LEVELS WITH ANTIBIOTIC SELF-MEDICATION IN THE COMMUNITY OF CIREBON Tridaya Putri Handayani; Muhammad Duddy Satrianugraha; Witri Pratiwi; Ruri Eka Maryam Mulyaningsih
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: People in developing countries, like Indonesia, often conduct self-medication. One of the most common drugs used in self-medication is antibiotics. Antibiotics should be used with caution since it can cause antibiotic resistance and possible unwanted side effects of the drug. There are several factors that influence self-medication behavior such as education and socio-economic levels. This research aims to find the correlation between education and social economic levels with antibiotic self-medication in the community of Cirebon.Method: This study was an analytical survey with cross-sectional method. This study was conducted from December 2018 to February 2019. A total of 300 respondents were recruited as samples using consecutive sampling technique. The respondents were recruited from 5 different pharmacies from each sub-district in Cirebon City and a validated questionnaire were used to obtain data. The collected data are analyzed using the Spearman correlation test.Results: The results of this study show that there was a significant but weak positive correlation of education level (r=0.224, p=0.001) and socio-economic (r=0.210, p=0.001) with self-medication using antibiotics. Conclusion: There is a significant positive correlation between education and socio-economic levels with antibiotic self-medication.
PERBANDINGAN JUMLAH KONTAMINASI TELUR SOIL TRANSMITTED HELMINTS (STHs) PADA SAYURAN SELADA (LACTUCA SATIVA) DI PASAR TRADISIONAL DAN PASAR MODERN KOTA CIREBON Ruri Eka Maryam Mulyaningsih; Thysa Thysmelia Affandi; Fauzany Reyhan Maulana
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 10 No 2 (2024): TUNAS MEDIKA JURNAL KEDOKTERAN & KESEHATAN
Publisher : Fakultas Kedokteran UGJ Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33603/tumed.v10i2.9458

Abstract

LATAR BELAKANG Soil Transmitted Helmints (STHs) adalah penyakit kecacingan yang merupakan penyakit endemik pada daerah tropis dan sub tropis. Selada (Lactuca sativa) merupakan bahan makanan yang banyak digunakan sebagai lalapan. Kontaminasi telur STHs pada sayuran selada yang dimakan dengan higienitas kurang baik dapat menyebabkan masalah klinis. Hal tersebut diketahui dengan sangat tingginya prevalensi di Indonesia yaitu antara 2,5 hingga 62%. TUJUAN Mengetahui persentase kontaminasi telur STHs dan jenis telur STHs terbanyak pada selada (Lactuca sativa), serta menganalisis perbandingan jumlah kontaminasi telur STHs pada selada di pasar modern dan pasar tradisional di Kota Cirebon. METODE Penelitian ini merupakan penelitian observasional analitik dengan pendekatan cross sectional. Pengambilan data menggunakan teknik cluster sampling. Analisis bivariat menggunakan uji chi square untuk membandingkan jumlah kontaminasi. HASIL Sayuran selada yang terkontaminasi telur STHs pada pasar tradisional 18 sampel (37,5%) dan pasar modern 9 sampel (18,8%). Jenis telur STHs terbanyak ialah Ascaris Lumbricoides di pasar tradisional 17 telur (77,3%) dan pasar modern 7 telur (58,3%). Ditemukan 4 jenis telur STHs yaitu Ascaris lumbricoides, Trichuris trichiura, Hookworm, Strongyloides stercoralis. Terdapat perbandingan jumlah kontaminasi telur STHs pada sayuran selada (Lactuca sativa) di pasar modern dan pasar tradisional dengan nilai p-value 0,041. SIMPULAN Hasil analisis bivariat diketahui kontaminasi telus STHs pada sayuran selada (Lactuca sativa) di lebih banyak di pasar tradisional dibandingkan di pasar modern kota Cirebon (p=0,041). Kata Kunci : Kontaminasi, Soil Transmitted Helminthes, Selada BACKGROUND Soil-transmitted helminths (STHs) is a helminthic disease that an endemic in tropical and sub-tropical areas. Lettuce (Lactuca sativa) is a common food ingredient in daily cooking. STHs egg contamination in lettuce vegetables eaten with poor hygiene can cause clinical problems. The prevalence of helminthiasis in Indonesia is 2,5-62%. OBJECTIVE To Knowing the highest percentage of STHs egg contamination and STHs egg types in lettuce (Lactuca sativa), as well as analyzing the comparison of the amount of STHs egg contamination in lettuce (Lactuca sativa) in modern and traditional markets in Cirebon City. METHODS This research an analytic observational study with a cross sectional approach. Data collection is using a cluster sampling. Bivariate analysis uses the chi-square test to compare the amount of contamination. RESULTS Contamination of STHs eggs in traditional 18 samples (37,5%) and modern markets were 9 samples (18,8%). Most STH egg types in traditional and modern markets are Ascaris Lumbricoides with 17 eggs (77,3%) and 7 eggs (58,3%). Types of STHs eggs were found, there are Ascaris lumbricoides, Trichuris trichiura, Hookworm, Strongyloides stercoralis. There is a significant comparison of the amount of STHs egg contamination in lettuce (Lactuca sativa) between modern markets and traditional markets with a p-value of 0.041. CONCLUSION The analysis of bivariate results found that lettuce vegetables (Lactuca sativa) in traditional markets in Cirebon City were more contaminated with STHs eggs than in modern markets in Cirebon City (p=0.041). Keyword : Contamination, Soil Transmitted Helminthes, Lettuce
Co-Authors Ahmad Fariz MZZ Apriyanto, Dadan Ramadhan Dela Destiani Aji Fauzany Reyhan Maulana Nita Safitri Rike Rizqilah RR. Ella Evrita Hestiandari Satrianugraha, Muhammad Duddy Thysa Thysmelia Affandi Tridaya Putri Handayani Witri Pratiwi