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. Suhanantyo
Sebelas Maret University
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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Pengaruh Ekstrak Bengkuang (Pachyrhizus erosus) terhadap Kadar Kolesterol Total Darah Tikus Putih (Rattus norvegicus) yang Diberi Diet Tinggi Lemak Tunikasari, Atma Sanggani; Suhanantyo, .; Dharmawan, Ruben
Nexus Biomedika Vol 3, No 1 (2014): Nexus Biomedika
Publisher : Nexus Biomedika

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (13.862 KB)

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Background : Cardiovascular disease is the leading cause of disability and death in the world. High levels of blood cholesterol becoming a risk factor in atherosclerosis is the leading cause of cardiovascular disease. Yam Bean contains flavonoids, isoflavones, phenols, and saponins which have an effect of antihyperlipidemia. This study aimed to determine the effect of Yam Bean (Pachyrhizus erosus) extract on blood total cholesterol level of rats (Rattus norvegicus) with a high fat diet. Methods : This research was an experimental laboratoric research using the post test only with control group design. The research subject were 30 male white rats, Sprague Dawley strain, 2 months old, and their weights were about 130-240 gram. The subjects were arranged into 6 groups. The whole groups were adapted for 7 days. All groups except normal control, were administered high fat diet 2 ml/200 gram BW/day for 21 days. The positive control group was administered 0.18 mg/200 g BW/day of simvastatin and the negative control group was administered 2.00 ml/200 g BW/day of distilled water. While the first, second and third treatment groups were consecutively administered 70 mg, 140mg and 210 mg/200 g BW/day of Yam Bean extracts. On the 22nd day, the blood samples of the subjects were taken from pre-orbital plexus for measurement of cholesterol levels. Then, the data were analyzed using One-way ANOVA test and Least Significance Difference test (LSD). Results : The One-way ANOVA test showed a significant difference in blood total cholesterol level among six groups (p = 0.001). Post Hoc Test showed a significant difference among two groups, except the third treatment group which had the same result and the normal control groups (p = 0.335). Conclusion : Yam Bean (Pachyrhizus erosus) extract had effect to decrease the blood total cholesterol levels of rats. Keywords : Yam Bean (Pachyrhizus erosus) extract, total  cholesterol levels, white rats. 
Pengaruh Ekstrak Bengkuang (Pachyrhizus erosus) terhadap Kadar Trigliserida Darah Tikus Putih (Rattus norvegicus) yang Diberi Diet Tinggi Lemak Fuad, Himmatul; Suhanantyo, .; Setyawan, Novan Adi
Nexus Biomedika Vol 3, No 1 (2014): Nexus Biomedika
Publisher : Nexus Biomedika

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (13.862 KB)

Abstract

Background: Yam Bean contains flavonoids, isoflavones, phenols, alkaloid, ascorbic acid and saponins which have the effect of antihyperlipidemia. This study aimed to determine the effect of Yam Bean (Pachyrhizus erosus) extract on blood triglyceride level of rats (Rattus norvegicus) with a high fat diet. Methods: This research was a true experimental laboratory research using the post test only with control group design. This research subjects were 30 male white rats, Sprague Dawley strain, 2 months old, and about 137-238 gram of their weight. The subjects were divided by random into 6 groups. The whole groups were adapted for 7 days. After a week, all groups except normal control group, were administered high fat diet 2 ml/200 gram BW/day for 21 days. In addition, the positive control group were also administerd 0.18 mg/200 g BW/day of simvastatin, while the negative control groups were administered 2 ml/200 g BW/day of distilled water. The first, second and third treatment groups were consecutively administered 70 mg, 140 mg and 210 mg/200 g BW/day of  Yam Bean extracts. In the 22th day, the blood samples of the subjects were taken from pre-orbital plexus to assess their triglyceride levels. The data were analyzed using One-way ANOVA test and Least Significance Difference test (LSD). Results: The One-way ANOVA test showed a significant difference in blood triglyceride level among six groups (p = 0.001). Whereas, Post Hoc test showed a significant difference among all groups, except the third treatment group which had no significant difference (p=0.768) to the positive control group. Conclusions: Yam Bean (Pachyrhizus erosus) extract significantly reduced blood triglyceride levels of rats. Keywords: Yam Bean (Pachyrhizus erosus) extract, triglyceride levels, white rats. 
Recurrrent Respiratory Infection (RRI) Frequency Influence the Nutritional Status of Children at Jebres Village Surakarta Sienviolincia, Denata; Suhanantyo, .; Suyatmi, .
Nexus Kedokteran Komunitas Vol 6, No 2 (2017): Nexus Kedokteran Komunitas
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: One of the things that directly affect the nutritional status is an infection. Acute Respiratory Infections often occur in children aged under 5 years old and often repeated. This research aims to determine the relationship of Reccurrent Respiratory Infection (RRI) frequency and the nutritional status of children under five years old. Methods : This research was analytical observational with case control design. This research was conducted at several posyandu of Jebres Village, Jebres Subdistrict, Surakarta, on November 2015. Sampling was done by purposive sampling technique. Sixty seven samples was classified into frequently RRI (30 children) designed as case group and infrequently RRI (37 children) as control group. The nutritional status was determined by W/A and H/A index interpreted into z-score. Data of RRI frequency obtained from questionnaires filled out by the mother. The data obtained were processed using SPSS for Windows 18.0 and analyzed by independent t test to analyze the difference of nutrional status at significance level of ? = 0.05. Results : Children who rarely affected by RRI has average z-score -0.61 SD for W/A and -0.86 SD for H/A. While children who often exposed RRI has average z-score -1.12 SD for W/A and -1.49 SD for H/A. The result of this research showed that there was significant difference of nutrional status between case and control group. RRI frequency with W/A index (p = 0,017) and RRI frequency with H/A index (p = 0,008). Conclusion : the significant difference of nutritional status between groups indicating  a relationship between Reccurrent Respiratory Infection (RRI) frequency and the nutritional status of children at Jebres Village Surakarta. Key words : Reccurrent Respiratory Infection (RRI), nutritional status
Co-Authors . Suyatmi Atma Sanggani Tunikasari Novan Adi Setyawan RUBEN DHARMAWAN Sienviolincia, Denata Syamsul Arifin