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All Journal Nexus Biomedika Majalah Obat Tradisional Universa Medicina Indonesian Journal of Medicine Journal of Social Research Plexus Medical Journal
Novan Adi Setyawan
Sebelas Maret University
Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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Efek Antifungi Seduhan Teh Hijau (Camellia sinensis L.) terhadap Pertumbuhan Candida albicans In Vitro Wardhani, Irene Ardiani Pramudya; Haryati, Sri; Setyawan, Novan Adi
Nexus Biomedika Vol 1, No 2 (2012): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background : Brewed green tea contains antifungal substance such as polyphenol which is considered can inhibit fungal growth.  The aim of this research is to determine antifungal effect of brewed green tea (Camellia sinensis L.) against Candida albicans growth In Vitro. Methods : The research was performed as experimental laboratory. The subject of this research were clinical sample of Candida albicans and taken randomly. This research used 7 treatment groups, they were sterilized aquadest as negative control, brewed green tea with concentration of 60%, 70%, 80%, 90% and 100%, also fluconazole 25 µg as positive control. This research was repeated four times. The plate was incubated at the temperature of 37ºC for 48 hours then inhibition diameter zone formed was measured. The data was analyzed by Linier Regression test then continued by Correlation test on IBM Statistics for Windows version 20. Results : The diameter of inhibition zone increased along with increasing concentrations, because higher concentration of brewed green tea contained more substances, and the diameter of concentration of 100% group is almost the same with diameter of positive control group. The results of statistical analysis using Linier Regression test showed that there are significant differences on seven of treatment groups (p < 0,05)  and the Correlation test showed that there are close relation between concentration of brewed green tea and the diameter of inhibition zone. Conclusion : Brewed green tea (Camellia sinensis L.) has antifungal effect against Candida albicans growth In Vitro. Start from concentration of 60% up to 100%, there were antifungal effect, and the antifungal effect of concentration of 100% is close to  fluconazole  25 µg/ml. Keywords : Antifungal Effect, Brewed Green Tea, Candida albicans 
Pengaruh Ekstrak Bengkuang (Pachyrhizus erosus) terhadap Kadar LDL Darah Tikus Putih (Rattus norvegicus) yang Diberi Diet Tinggi Lemak Wijayanto, Rukmana; ., Suhanantyo; Setyawan, Novan Adi
Nexus Biomedika Vol 2, No 3 (2013): Nexus Biomedika
Publisher : Nexus Biomedika

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Background: Cardiovascular disease is the leading cause of disability and early death in the world. Increasing of blood LDL level is one risk factor for atherosclerosis that can develop into cardiovascular disease.Yam Bean contains isoflavones, flavonoids, phenols, and saponins which have hipolipidemic effect. This study  aimed to determine the effect of Yam Bean (Pachyrhizus erosus) extract on blood LDL level of rats (Rattus norvegicus) with a high fat diet. Methods: This study was an experimental laboratory using post-test only with control group design. The subjects were 30 male Sprague Dawley (Rattus norvegicus) rats, two-months old with 130-240 grams of body weight (BW) that were divided into 6 groups randomly. Group KN was administered a normal diet, while K(+) was administered a high fat diet and simvastatin 0.18 mg/200 g BW/day. The group K(-) was administered aquadest and a high fat diet, while group P1, P2 and P3 were not only administered Yam Bean extract 70 mg, 140 mg and  210 mg/200 g BW/day, in a row, but also a high fat diet.  High fat diet was cow’s brains which was administered 2 ml/200 g BW/day. Administration of Yam Bean extract, simvastatin, and high fat diet were performed for 21 days. Blood samples were taken on 22nd day at plexus preorbitalis. The LDL level was measured by CHOD-PAP method. Data were analyzed by One way ANOVA test and the Least Significance Difference (LSD) test (α=0.05). Results: The highest LDL level was on group K(-), followed by P1, P2, K(+), P3, while the lowest was KN. One way ANOVA test showed p=0.001. Whereas LSD test showed significant differences among each other groups (p<0.05) except between the group K(+) and P3 (p=0.174). Conclusion: Yam Bean extract showed a significant effect on blood LDL level of rats with a high fat diet. Increasing the dose of Yam Bean extract had positive correlation on decreasing blood LDL level of rats with a high fat diet. Keywords: Yam Bean extract, LDL, high fat diet 
Pengaruh Ekstrak Bengkuang (Pachyrhizus erosus) terhadap Kadar Trigliserida Darah Tikus Putih (Rattus norvegicus) yang Diberi Diet Tinggi Lemak Fuad, Himmatul; Suhanantyo, .; Setyawan, Novan Adi
Nexus Biomedika Vol 3, No 1 (2014): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background: Yam Bean contains flavonoids, isoflavones, phenols, alkaloid, ascorbic acid and saponins which have the effect of antihyperlipidemia. This study aimed to determine the effect of Yam Bean (Pachyrhizus erosus) extract on blood triglyceride level of rats (Rattus norvegicus) with a high fat diet. Methods: This research was a true experimental laboratory research using the post test only with control group design. This research subjects were 30 male white rats, Sprague Dawley strain, 2 months old, and about 137-238 gram of their weight. The subjects were divided by random into 6 groups. The whole groups were adapted for 7 days. After a week, all groups except normal control group, were administered high fat diet 2 ml/200 gram BW/day for 21 days. In addition, the positive control group were also administerd 0.18 mg/200 g BW/day of simvastatin, while the negative control groups were administered 2 ml/200 g BW/day of distilled water. The first, second and third treatment groups were consecutively administered 70 mg, 140 mg and 210 mg/200 g BW/day of  Yam Bean extracts. In the 22th day, the blood samples of the subjects were taken from pre-orbital plexus to assess their triglyceride levels. The data were analyzed using One-way ANOVA test and Least Significance Difference test (LSD). Results: The One-way ANOVA test showed a significant difference in blood triglyceride level among six groups (p = 0.001). Whereas, Post Hoc test showed a significant difference among all groups, except the third treatment group which had no significant difference (p=0.768) to the positive control group. Conclusions: Yam Bean (Pachyrhizus erosus) extract significantly reduced blood triglyceride levels of rats. Keywords: Yam Bean (Pachyrhizus erosus) extract, triglyceride levels, white rats. 
A Ekstrak Etanolik Daun Kelor (Moringa oleifera, Lam) Menurunkan Ekspresi Caspase-3 Testis Tikus Wistar (Rattus norvegicus) Model Sindrom Metabolik Terinduksi Zhahira, Thania Nur; Budiani, Dyah Ratna; Setyawan, Novan Adi
Plexus Medical Journal Vol. 3 No. 2 (2024): April
Publisher : Fakultas Kedokteran, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/plexus.v3i2.229

Abstract

Pendahuluan: Sindrom metabolik berpengaruh terhadap kesuburan pria karena dapat menyebabkan infertilitas. Infertilitas antara lain disebabkan oleh kematian berlebih sel – sel spermatogenik selama spermatogenesis. Caspase-3 memiliki peran penting sebagai eksekutor apoptosis. Kandungan ekstrak etanolik daun kelor diketahui dapat mencegah apoptosis dengan menurunkan ekspresi caspase-3. Penelitian ini dilakukan dengan tujuan mengetahui pengaruh peningkatan dosis ekstrak etanolik daun kelor terhadap tingkat ekspresi caspase-3 pada jaringan testis tikus Wistar model sindrom metabolik. Metode: Metode penelitian yang digunakan adalah eksperimental laboratorik. Tikus Wistar berjumlah 30 ekor dibagi menjadi 5 kelompok dengan jumlah yang sama. KI sebagai kelompok kontrol negatif, KII sebagai kelompok sindrom metabolik terinduksi, KIII, KIV, dan KV sebagai kelompok sindrom metabolik terinduksi yang diberi dosis ekstrak etanolik daun kelor secara berurutan sebesar 150 mg/kgBB, 250 mg/kgBB, dan 350 mg/kgBB. Ekspresi caspase-3 dihitung menggunakan metode semikuantitatif IDS. Selanjutnya, ekspresi caspase-3 dianalisis menggunakan uji One-Way ANOVA, Post Hoc Tukey HSD, dan uji regresi linier. Hasil: KII memiliki skor ekspresi caspase-3 tertinggi yaitu 89,45 dan KV memiliki skor ekspresi caspase-3 terendah yaitu 25,93. Hasil uji One-Way ANOVA ekspresi caspase-3 pada jaringan testis tikus Wistar adalah 0.00 (p<0.05) yang artinya terdapat perbedaan signifikan ekspresi caspase-3 pada semua kelompok. Perbedaan bermakna terdapat antara KI dengan KII dan KII dengan KIII, KIV, dan KV. Hasil uji regresi linier menunjukkan pengaruh negatif antara dosis ekstrak etanolik daun kelor terhadap ekspresi caspase-3. Kesimpulan: Pemberian dosis ekstrak etanolik daun kelor yaitu 150 mg/kgBB, 250 mg/kgBB, dan 350 mg/kgBB dapat menurunkan ekspresi caspase-3.
Effect of Ethanolic Extract in Moringa oleifera, Lam. Leaf on Uric Acid Levels and Body Surface Area of Kidney Glomerulus in Wistar Rats (Rattus novergicus) Induced Metabolic Syndrome Model Darmawan, Muhammad Dzaki; Subandono, Jarot; Setyawan, Novan Adi; Budiani, Dyah Ratna
Indonesian Journal of Medicine Vol. 6 No. 4 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: There has been an increasing prevalence of metabolic syndrome (MS) caused by life style such as sedentary behavior and western diet. Metabolic syndrome causes degeneration in ren’s structure and processes the elimination of by product in metabolism, which is uric acid. Moringa oleifera Lam. leaves contain antioxidant that can repair damages caused by MS. Studies about improvement of ren’s structure and uric acid level related to Moringa oleifera Lam. leaves’ consumption has not been found yet. Therefore, this study was intended to examine the effects of ethanolic extract in Moringa oleifera Lam. leaves to uric acid and glomerular surface area in male wistar rat (Rattus norvegicus) with induced metabolic syndrome model.Method: This study is an experimental laboratory study. The subjects of this study consisted of 30 rats which were divided into 5 groups with 6 in each group. K1 is control group, K2 is MS group, and K3, K4, and K5 are MS groups given variety of ethanolic extract doses. The induction of MS was done by giving high-fat diet in 28 days and injection of streptozotocin-nicotinamide (STZ-NA) in the 25th day. Rats in group K3, K4, and K5 were given doses of 150, 250, and 350 mg/kgBW in 28 days.Results: The administration of high-fat diet for 28 days and injection of STZ-NA caused MS condition in rats.  Repeated ANOVA and One-Way Anova test showed that the administration of ethanolic extract in Moringa oleifera Lam. leaves with doses of 150, 250, and 350 mg/kgBW in 28 days decreased uric acid significantly (p= 0.001; p=0.001; p= 0.001). Another result also found that ethanolic extract from Moringa oleifera Lam. leaves with doses of 250 and 350 mg/kgBW increased area of glomerular surface area in rats significantly.Conclusion: The administration of ethanolic extract from Moringa oleifera Lam. leaves with doses of 150, 250, and 350 mg/kgBW for 28 days decreased uric acid level in rats. Ethanolic extract of Moringa oleifera Lam. leaves 250 and 350 mg/kgBw doses increase glomerular surface area.Keywords: Moringa Oleifera, uric acid, glomerular cross-sectional area, metabolic syndrome, kidneyCorrespondence: Muhammad Dzaki Darmawan. Study Program of Medical Doctor Education, Faculty of Medicine, Universitas Sebelas Maret. Email: mdddzaki@student.uns.ac.id.Indonesian Journal of Medicine (2021), 06(04): 412-422https://doi.org/10.26911/theijmed.2021.06.04.07
Effect of Ethanolic Extract of Moringa oleifera, Lam. Roots on Expression of Cyclin D1 in Testicular Tissue of Metabolic Syndrome Induced Wistar Rats Lutfi, Sephendra; Budiani, Dyah Ratna; Setyawan, Novan Adi
Indonesian Journal of Medicine Vol. 8 No. 2 (2023)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2023.8.2.562

Abstract

Background: Metabolic syndrome (MS) impacts on inhibition process of spermatogenesis by damaging various components of cell cycle proteins. Cyclin D1 protein which plays role in regulating the cell cycle of spermatogenic cells is depleted due to the metabolic syndrome. Variation results of M. oleifera studies on fertility are interesting for further research. This study aimed to determine the effect of ethanolic extract of M. oleifera roots towards expression of testicular cyclin D1 of metabolic syndrome induced Wistar rats.Subjects and Method: This study was an experimental laboratory. Thirty subjects of male Wistar rats were randomly divided into 5 groups consisted of 6 rats, control group (K1), MS group (K2), and treatment groups (K3, K4, and K5) which were given doses of 150, 250, and 350 mg/kgBW, respectively for 28 days. Induction of MS was achieved by high-fat diet for 28 days and injection of streptozotocin-nicotinamide (STZ-NA) on day 25. Cyclin D1 data was calculated using Intensity Distribution Score (IDS) and analyzed using one-way ANOVA test followed by post hoc multiple comparisons with Tukey HSD. Simple liniar regression test conducted on cyclin D1 data of K2, K3, K4, and K5.Results: One-way ANOVA test showed that the administration of ethanolic extract M. oleifera Lam. roots with doses of 150, 250, and 350 mg/kgBW in 28 days increased cyclin D1 significantly (p= 0.000). There were significant differences between K1 and K2 (p= 0.000), K2 and K3 (p= 0.000), K2 and K4 (p= 0.000), K2 and K5 (P= 0.000). Liniar regression test showed significant (p= 0.000) and moderate effect (R2= 0.65) of doses of ethanolic extract of M. oleifera roots on the expression of cyclin D1.Conclusion: The administration of ethanolic extract Moringa oleifera Lam. roots with doses of 150, 250, and 350 mg/kgBW for 28 days increased cyclin D1 in testicular rats.
Topical Application Type of Fish Oil Promotes Re-Epithelialization in Burn Wound Healing in Rats Sasongko, Heru; Pitaloka, Nirwana Asri Diah; Kurniawan, Muhammad Rizki; Pramono, Edi; Setyawan, Novan Adi; Rohman, Abdul
Majalah Obat Tradisional Vol 30, No 2 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.95644

Abstract

Burns are a condition that is often found in the world in various cases such as accidents. The incidence of burns will probably increase as human activities become more complex. Wounds that are not treated immediately tend to become infected and cause death. Fish oil is one of the ingredients that has been studied for wound healing. Previous research shows that fish oil is rich in long-chain omega-3 fatty acids such as docosahexaenoic acid and eicosapentaenoic acid, which have anti-inflammatory effects. However, there has not been much research on the type of fish oil used and the wound healing process. The aim of this study was to determine the wound-healing activity of milkfish (Chanos chanos Forsskal.), patin (Pangasius djambal), and eel (Anguilla bicolor) fish oil. Tests were carried out on 25 mice as an experimental animal model for burn wounds. Data on percent wound reduction and the re-epithelialization process were statistically calculated using one-way analysis of variance (ANOVA) followed by a post-hoc LSD test. The research results showed that milkfish oil, patin fish oil, and eel fish oil in a concentration of 10% on an ointment basis were able to reduce wounds significantly. Eel fish oil shows the greatest burn wound healing process with re-epithelialization when compared to other oils. The type of fish oil affects the wound healing process.
Cluster Differentiation 133 Expression in Patients With Basal Cell Carcinoma: an Immunohistochemical Review Utama, Rahmat Firdaus Dwi; Dharmawan, Nugrohoaji; Murastami, Ammarilis; Mulianto, Nurrachmat; Setyawan, Novan Adi
Journal of Social Research Vol. 4 No. 10 (2025): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v4i9.2802

Abstract

Basal cell carcinoma (BCC) is the most common non-melanoma skin cancer in humans, developing on skin exposed to ultraviolet light and rarely metastasizing. Cancer stem cell markers such as CD133 have been extensively studied in various malignancies, but their expression in BCC remains controversial and has not been widely studied in Indonesia. Determine the difference in CD133 expression between BCC patients and normal skin. Analytical observational study with a case control design was conducted at Dr. Moewardi General Hospital in Surakarta from April to July 2025. The sample included 13 BCC tissues and 13 normal skin controls taken by consecutive sampling from paraffin blocks from 2021-2024. CD133 immunohistochemical staining was performed with Allred scoring by a single pathologist on at least four random fields of view. Descriptive analysis presented demographic characteristics and Allred scores, while the Chi square test was used to compare CD133 expression between groups with significance at p < 0.05. The mean CD133 Allred score was 7.15 ± 0.56 in KSB tissue and 7.31 ± 0.48 in normal skin. Strongly positive CD133 expression was found in 12/13 BCC patients and 13/13 normal skin. Chi square analysis showed no significant difference in CD133 expression between the BCC and normal skin groups (p=0.308). CD133 expression based on the Allred score did not differ significantly between BCC tissue and normal skin, indicating that CD133 is not useful as a single marker for the diagnosis or prognosis of KSB
Retinoblastoma tumor suppressor protein is not a risk factor for the location of condyloma acuminatum among adults Primisawitri, Pratiwi Prasetya; Mulianto, ⁠Nurrachmat; Ellistasari, Endra Yustin; Poncorini, Eti; Kariosentono, ⁠⁠Harijono; Widhiati, Suci; Wasita, Brian; Setyawan, Novan Adi; Yudhistira, Muhammad Yurizar
Universa Medicina Vol. 44 No. 3 (2025): Ahead Of Print
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2025.v44.343-349

Abstract

BackgroundCondylomata acuminata (CA) are sexually transmitted infections primarily caused by low-risk HPV types 6 and 11. Retinoblastoma protein (pRb) interacts with HPV oncoproteins, leading to destabilization, genomic instability, and carcinogenesis. This study aimed to determine whether variations in pRb expression and sexual orientation are risk factors of the anatomical location of CA lesions and to compare differences in pRb expression by sexual orientation. MethodsA cross-sectional study was conducted among 33 patients aged >18 years with clinically and histopathologically confirmed CA. Demographic data, pRb expression assessed via excision biopsy and immunohistochemistry, and relevant risk factors were collected. Statistical analyses including Simple and multiple binary logistic regression were used to analyze the data, with model fit assessed using the Hosmer–Lemeshow test. ResultsWeak pRb expression predominated in anal lesions (92.3%; p=0.018) and among homosexual/bisexual individuals (57.9%; p=0.031), while moderate expression was more common in genital lesions (66.7%; p=0.018) and heterosexual individuals (57.1%; p=0.011). Simple logistic regression  analysis showed that HIV status (OR=11.88; p=0.025), sexual orientation (OR=13.33; p=0.001), and moderate-to-strong pRb expression (OR=24.00; p=0.008; OR=12.00; p=0.048) were associated with lesion location. In the multivariate model, pRb expression was excluded due to multicollinearity. Sexual orientation remained the only independent predictor of lesion location (Adj OR=8.89; p=0.023), with heterosexual individuals more likely to present with genital lesions. ConclusionThe expression of pRb was not a risk factor of the anatomical location of CA, and differed between genital and anal CA. However, sexual orientation emerged as the dominant independent factor associated with lesion location.   
Co-Authors . Suhanantyo Abdul Rohman Brian Wasita Darmawan, Muhammad Dzaki Dharmawan, Nugrohoaji Dyah Ratna Budiani Edi Pramono Ellistasari, Endra Yustin Heru Sasongko Irene Ardiani Pramudya Wardhani Jarot Subandono Kariosentono, ⁠⁠Harijono Lutfi, Sephendra Muhammad Rizki Kurniawan, Muhammad Rizki Mulianto, ⁠Nurrachmat Murastami, Ammarilis Nurrachmat Mulianto Pitaloka, Nirwana Asri Diah Poncorini, Eti Primisawitri, Pratiwi Prasetya Rukmana Wijayanto Sri Haryati Suhanantyo . Syamsul Arifin Utama, Rahmat Firdaus Dwi Widhiati, Suci Yudhistira, Muhammad Yurizar Zhahira, Thania Nur