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FX.Bambang Sukilarso S
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Biochemistry, Genetics & Molecular Biology

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Efek Anti Fungi Ekstrak Etanol Kulit Buah Manggis (Garcinia Mangostana, Linn.) Terhadap Pertumbuhan Candida Albicans Secara In Vitro ., Puspaningrum; Sukilarso S, FX.Bambang; Wijayanti, Lilik
Nexus Biomedika Vol 2, No 3 (2013): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background: This study aimed to know the inhibitory effect of the etanol extract of mangosteen rind (Garcinia mangostana, Linn.) on the growth of Candida albicans in vitro. Methods: The method used in this study was quasi-experimental laboratory research. The subject was the ethanol extract of the mangosteen fruit (Garcinia mangostana Linn.) rind. Candida albicans grown on sabouraud dextrose agar were treated with 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, and 100% of the ethanol extract of mangosteen rind (Garcinia mangostana, Linn.), as well as fluconazole 25μg (drugs that were already on the market) as positive control for 24 hours at 37° C on petri dish. The data of diameter of inhibition zone obtained were analyzed with regression-correlation test using SPSS 11.5 for windows. Results: The diameters of inhibition zone on culture of Candida albicans treated with the ethanol extract of the mangosteen fruit with concentration of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, and fluconazole 25μg were 0 mm, 0 mm, 1.75 mm, 1.75 mm, 2.00 mm, 2.00 mm, 3.00 mm, 3.50 mm, 3.75 mm, 3.75 mm and 0 mm, in a row. The regression-correlation analysis showed that the correlation (r) between the diameter of inhibition zone and the levels of ethanol extract of mangosteen rind was 0.936 (p 0.000). Conclusion: The ethanol extract of mangosteen rind (Garcinia mangostana, Linn.) had antifungal effect on the growth of Candida albicans in vitro. Keywords: antifungal effects, ethanol extract of mangosteen rind (Garcinia mangostana Linn.), Candida albicans.  
Efek Anti Fungi Ekstrak Etanol Kulit Buah Manggis (Garcinia Mangostana, Linn.) Terhadap Pertumbuhan Candida Albicans Secara In Vitro Puspaningrum .; FX.Bambang Sukilarso S; Lilik Wijayanti
Nexus Biomedika Vol 2, No 3 (2013): Nexus Biomedika
Publisher : Nexus Biomedika

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: This study aimed to know the inhibitory effect of the etanol extract of mangosteen rind (Garcinia mangostana, Linn.) on the growth of Candida albicans in vitro. Methods: The method used in this study was quasi-experimental laboratory research. The subject was the ethanol extract of the mangosteen fruit (Garcinia mangostana Linn.) rind. Candida albicans grown on sabouraud dextrose agar were treated with 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, and 100% of the ethanol extract of mangosteen rind (Garcinia mangostana, Linn.), as well as fluconazole 25?g (drugs that were already on the market) as positive control for 24 hours at 37 C on petri dish. The data of diameter of inhibition zone obtained were analyzed with regression-correlation test using SPSS 11.5 for windows. Results: The diameters of inhibition zone on culture of Candida albicans treated with the ethanol extract of the mangosteen fruit with concentration of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, and fluconazole 25?g were 0 mm, 0 mm, 1.75 mm, 1.75 mm, 2.00 mm, 2.00 mm, 3.00 mm, 3.50 mm, 3.75 mm, 3.75 mm and 0 mm, in a row. The regression-correlation analysis showed that the correlation (r) between the diameter of inhibition zone and the levels of ethanol extract of mangosteen rind was 0.936 (p 0.000). Conclusion: The ethanol extract of mangosteen rind (Garcinia mangostana, Linn.) had antifungal effect on the growth of Candida albicans in vitro. Keywords: antifungal effects, ethanol extract of mangosteen rind (Garcinia mangostana Linn.), Candida albicans.
Co-Authors Lilik Wijayanti Lilik Wijayanti Puspaningrum .