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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Sri Sulistiandari
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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SEL PLASMA LEUKEMIA HUBUNGAN DENGAN MIELOFIBROSIS Sri Sulistiandari; Budiman .
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 3 (2008)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i3.937

Abstract

Plasma cell leukemia (PCL) is a variant form of myeloma which contain more than >20% plasma cells and an absolute plasmacell content ≥ 2.000/mm3 in peripheral blood. PCL is a rare disorder, whole PCL with myelofibrosis is even more rare disorder. Thecorrelation between plasma cell leukemia and myelofibrosis is unclear. A 59-years-old woman referred to our hospital with generalweakness and severe anemia. Physical examination: looks pale, anaemic of conjunctiva, hepatosplenomegaly. The laboratory findingsare Hb 4.1 gr/dL, MCV 81 fL, MCH 26.7 pg, leucocytes 22.500/mm3, thrombocytes 26.000/mm3, reticulocytes 1.8%. The peripheralblood showed leucoerythroblastic morphology with teardrop cells and 32% plasma cells. Bone marrow aspiration revealed massiveplasma cell infiltrations (90%). Protein electrophoresis showed hypogammaglobulinemia. There is no evidence of osteolitic bone lesionon radiological examination. Clinical and laboratory finding above support the diagnosis of Primary Plasma Cell Leukaemia that maylead to myelofibrosis as a complication. Bone marrow biopsy is required to confirm diagnosis of myelofibrosis.
Result Comparison of Fecal Occult Blood Test between FOBT Hb and FOBT Hb tambah Tranferrin in Detecting Upper Gastrointestinal Tract Bleeding Anik Widijanti; Sri Sulistiandari; Tony Hariyanto; Rahma Triliana
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 11, NUMBER 1, April 2010
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/11120102-6

Abstract

Background: Immunological fecal occult blood test (FOBT) using anti human hemoglobin (Hb) has a low sensitivity in detecting upper gastrointestinal (GI) bleeding, due to Hb degradation. Transferrin (Tf) is more stable in stool when compared to Hb, provides an alternatives on diagnosing upper GI bleeding. This study aim to determine the advantage of FOBT Hb + Tf in detecting upper GI bleeding compared with FOBT Hb alone. Method: This study was conducted by comparing the diagnostic value of Rapid Immunochromatographic FOBT that use anti-human Hb alone, with the one using combination of anti human Hb Tf simultaneously in detecting upper GI bleeding. Stool sample from 48 patients with upper GI bleeding and 29 controls (without any upper GI bleeding) were collected then tested with both FOBT Methods. Endoscopy study was used as gold standard endoscopy to determine test’s diagnostic value. Result: In detecting upper GI bleeding, the sensitivity of FOBT Hb + Tf (85.42%) was higher than FOBT Hb (29.17%). The specifity of both Methods were accurate at 89.66% and 93.10% respectively. Positive predictive values (PPV) for both Methods were also good at 93.18% and 87.50% while negative predictive value (NPV) FOBT Hb + Tf (78.79%) were higher than FOBT Hb (44.26%). Conclusion: Between these two test Methods on detecting upper GI bleeding, FOBT Hb + Tf has higher sensitivity, PPV and NPV value compared to FOBT Hb. It is advisable to use FOBT Hb + Tf for upper GI bleeding screening. Keywords: FOBT, immunochromatography, hemoglobin, transferrin, upper GI bleeding
Co-Authors Anik Widijanti Anik Widijanti Budiman . Rahma Triliana Tony Hariyanto