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All Journal Jurnal Kedokteran Brawijaya Majalah Kesehatan FKUB MEDICINUS
Anik Widijanti
Laboratorium Sentral RSU dr. Saiful Anwar Malang
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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PERANAN LABORATORIUM DALAM MENUNJANG PENATALAKSANAAN PENDERITA Widijanti, Anik
Jurnal Kedokteran Brawijaya Vol 18, No 1 (2002)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2201.204 KB)

Abstract

Banyak faktor yang dapat menyebabkan ketidaksesuaian hasil pemeriksaan laboratorium dengan keadaan klinik penderita. Hal tersebut dapat diatasi dengan komunikasi antar petugas laboratorium dan klinisi, serta interpretasi yang tepat dari hasil pemeriksaan laboratorium. Dokter laboratorium bertugas untuk mengatasi masalh di bidang laboratorium dengan berbagai cara yaitu mengawasi mutu pemeriksaan sehingga sampelnya memenuhi syarat, persiapan penderita memadai, metodenya tepat, administrasi dan interpretasi hasil pemeriksaan secara benar. Perlu difahami mengenai ?cut off?, nilai rujukan dan nilai kritis, sensitifitas dan spesifitas tes, agar interpretasi hasil pemeriksaan laboratorium menjadi baik. Pada keadaan tertentu perlu diberikan komentar laboratorium pada jawaban interpretatif. Indikasi pemeriksaan dan interpretasi hasil pemeriksaan yang tepat akan sangat menunjang penatalaksaan penderita. Untuk itu dibutuhkan komunikasi klinisi dan laboratorium  yang dilakukan dengan membuat laporan interpretatif, konsultasi langsung pribadi maupun dalam ?team?. Hasil pemeriksaan petugas laboratorium yang tidak sesuai keadaan klinik penderita dikembalikan kepada dokter penanggung jawab laboratorium yang sama untuk diselesaikan permasalahannya.
EFEK KOMBINASI KLOROKUIN DAN N-ACETYL CYSTEINETERHADAP JUMLAH TROMBOSIT MENCIT GALUR BALB/C YANG DIINFEKSI Plasmodium berghei Mulyastuti, Yuanita; Widijanti, Anik; Ali, Mulyohadi; Iskandar, Agustin; Fitri, Loeki Enggar
Jurnal Kedokteran Brawijaya Vol 20, No 1 (2004)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (228.731 KB) | DOI: 10.21776/ub.jkb.2004.020.01.8

Abstract

Malaria is the most important of the parasitic diseases of humans. In Indonesia, about more than 70 million people live in area which is endemic to malaria, about 15 million new case ofmalaria occurred every year. In malaria immune response forms free radical which assist to eliminate the cause of disease but  also destroys endothelial cells at various organ. This oxidative damage plays an important role in the development of malarial thrombocytopenia. The aim of this research was to investigate the effect of Choroquine combine with N-Acetyl cysteine on the degree of parasitemia and platelets amount during malaria infection. Combination of Chloroquine and N-Acetyl cysteine have been tested by using experimental research method in male Balb/c mice which was infected by Plasmodium berghei. Measurement of the degree ofparasitemia was done everyday and the amount of the platelet as one of the nonspecific cellular immunity parameter at malaria was calculated once in three days. Treatment group were divided to eight groups, group of chloroquine(0,05 mg/gr), group of N-Acetylcysteine with dose 0,25 mg/gr, 0,5 mg/gr, and 1 mg/gr and also combination group of chloroquine and N-Acetyl cysteine with constant dose of chloroquine(0,05 mg/gr) and various dose of N-Acetyl cysteine(0,25 mg/gr, 0,5 mg/gr, and 1 mg/gr). One group consistedof infected mice without treatment as control group.
Laporan Kasus : WANITA USIA 20 TAHUN DENGAN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) DAN HbA1c RENDAH PALSU Santoso, Jessica; Widijanti, Anik
Majalah Kesehatan FKUB Vol 6, No 4 (2019): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (471.112 KB) | DOI: 10.21776/ub.majalahkesehatan.2019.006.04.6

Abstract

Pengukuran HbA1c memberikan informasi mengenai kadar gula pasien selama tiga bulan. Kadar HbA1c rendah palsu dapat dipengaruhi oleh beberapa faktor seperti hemoglobinopati, anemia, turnover eritrosit abnormal (anemia hemolitik, perdarahan, transfusi darah, anemia defisiensi Fe). Kami melaporkan presentasi klinis pada pasien wanita yang memiliki kadar HbA1c sangat rendah (1,8%) yang diakibatkan oleh anemia hemolitik pada SLE. Seorang wanita usia 20 tahun datang dengan keluhan utama sesak napas, disertai adanya badan terasa lemas, nafsu makan menurun, dan kedua kaki bengkak. Pasien memiliki riwayat PDA (patent ductus arteriosus). Pemeriksaan fisik menunjukkan takikardia, takipnea, konjungtiva anemis, ruam malar, distensi JVP (jugular venous pressure), kardiomegali dengan murmur sistolik, ronki basal paru bilateral, dan edema tungkai bawah. Pemeriksaan laboratorium menunjukkan anemia normokrom makrositer, trombositopenia, peningkatan RDW (red cell distribution width), HbA1c 1,8%, hipoalbuminemia, alkalosis respiratorik, proteinuria dan hematuria. Tes Coombs’ positif 3, ANA dan anti-dsDNA positif. Ekokardiogram menunjukkan PDA sedang. Rendahnya kadar HbA1c diakibatkan menurunnya usia eritrosit. Namun, terlalu cepatnya turnover eritrosit seperti pada anemia hemolitik dapat menyebabkan hemoglobin tidak dapat terglikasi sehingga kadar HbA1c menjadi rendah palsu.  Disimpulkan hasil pemeriksaan HbA1c tidak akurat pada pasien dengan anemia hemolitik pada SLE. Maka, disarankan melakukan pemeriksaan gula darah puasa dan gula darah 2 jam post prandial.   
Congenital Analbuminemia Santosa, Putu Adi; Widijanti, Anik; Susianti, Hani; Intanwati, Sherly; Meilani, Rossy
MEDICINUS Vol. 33 No. 2 (2020): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (111.628 KB) | DOI: 10.56951/medicinus.v33i2.50

Abstract

Congenital analbuminemia (CAA) is a rare autosomal recessive disorder, characterized by the absence or very low level of serum albumin (human serum albumin/HSA) as a result of defect on chromosome 4 which encodes albumin. It is defined as albumin level <1 g/l with normal liver function and the absence of protein loss.1,2 Estimated CAA prevalence is less than 1 in 1 million.A 10-year-old boy suffered from generalized edema that got worsened since last month. The patient had been misdiagnosed with nephrotic syndrome 2 years earlier, and then became protein-losing enteropathy. Neither cough nor diarrhea were reported. The patient had history of food allergy. Physical examination showed moderately ill condition, Glasgow Coma Scale (GCS) score E4 V5 M6, blood pressure 90/50 mmHg, pulse 120 x/min, respiratory rate 30x/min, palpebral edema, shifting dullness, undulation (+), with nonpitting edema on the extremities. Laboratory findings: leukocytosis (neutrophilia), peripheral blood smear showed hypochromic microcytic anisositosis erythrocyte. AAT serum 246 mg/dl, GGT serum: 88 U/l, iron serum 28 µg/dl, TIBC 411 µg/dl, transferrin saturation 7%, total IgE 775,90 U/ml. Serum Protein Electrophoresis (SPE) results were hypoalbuminemia (1,4 g/dl), hypogammaglobulinemia (0,21 g/dl), and total protein 2,91 g/dl. Chest X-ray showed pneumonia with minimal right pleural effusion. Overestimation of serum albumin level was caused by alpha and beta globulin that were detected as albumin in bromocresol green (BCG) methods. CAA aggravated with by allergy caused malnutrition in this patient. These data support the diagnosis of CAA with sepsis and iron deficiency anemia. Suggestion for the management consist of blood culture, procalcitonin level measurement, inguinal lymph node biopsy, DNA sequence analysis, also analysis of pleural and ascites fluid.
Pubertas Prekoks Perifer Isoseksual akibat Juvenille Granulosa Cell Tumor Santosa, Putu Adi; Widijanti, Anik; Susianti, Hani; Engli, Katherina Alfa
MEDICINUS Vol. 33 No. 3 (2020): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (572.213 KB) | DOI: 10.56951/medicinus.v33i3.66

Abstract

A 16-month-old girl with peripheral isosexual precocious puberty due to juvenile granulosa cell tumor underwent unilateral salpingo-oophorectomy procedure to stop the symptoms of precocious puberty. The diagnosis was established based on the patient’s medical history, physical findings, laboratory and other examinations which demonstrated secondary sexual characteristics according to Tanner scale M3P2, presence of abdominal mass, elevated serum estradiol, and a histological finding of juvenile granulosa cell tumor. Karyotyping results was normal. Left salpingo-oophorectomy successfully reduced estradiol concentration and stop the menstruation, while the other secondary sexual characteristics is monthly assessed at the clinic.
Co-Authors Agustin Iskandar Engli, Katherina Alfa Hani Susianti Intanwati, Sherly Loeki Enggar Fitri Meilani, Rossy Mulyohadi Ali Putu Adi Santosa, Putu Adi Rahma Triliana Santoso, Jessica Sri Sulistiandari Tony Hariyanto Yuanita Mulyastuti