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All Journal Medical Journal of Indonesia The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia
Heru Sundaru
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Medicine & Pharmacology

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House dust mite allergen level and allergen sensitization as risk factors for asthma among student in Central Jakarta Sundaru, Heru
Medical Journal of Indonesia Vol 15, No 1 (2006): January-March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (133.372 KB) | DOI: 10.13181/mji.v15i1.213

Abstract

This study is a community-based study to get an overview about House Dust Mite (HDM) allergen level, allergen sensitization as risk factors of asthma. This is a cross-sectional study on 3,840 students from 19 junior high schools, aged 13-14 years. All of the respondents filled out the International Study on Asthma and Allergy in Children (ISAAC) questionnaire. Of 3840 respondents, 288 (7.5%) were assigned to asthma group (experience wheezing during the last 12 months). The skin prick test was performed on 207 respondents and the house dust mite was collected from 135 respondents. Of 2601 respondents in non-asthma group, the skin prick test was randomly performed on 274 respondents and the house dust mite was collected from 165 respondents. There is no significant difference on HDM allergen concentration for Der p1, Der f1 or Group I between asthma and control group. The risk of asthma was caused especially by sen D.pteronyssinus (crude odds ration (OR): 12.68, 95% confidence interval (CI): 7.50-21.44), D.farinae (OR: 10.50, CI: 6.35-17.34) and cockroach allergen (OR:5.57, CI:3.44-9.01). The risk for asthma was not correlated with the level of house dust mite allergens but its sensitization. In conclusion, sensitization to HDM and cockroach allergen should be concerned in order to reduce risk and prevalence of asthma. (Med J Indones 2006; 15:55-9)Keywords: house dust mite, allergen sensitization, asthma, risk factor
The Pathogenic Triad of Chronic Cough: Postnasal Drip Syndrome, Asthma, and Gastroesophageal Reflux Disease Wulyo Rajabto; Ari Fahrial Syam; Heru Sundaru
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 8, ISSUE 1, April 2007
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/81200720-23

Abstract

Chronic cough, lasting for 3 weeks or more, is one of the most common symptoms for which adult patients seek medical attention. The pathogenic triad of chronic cough is Postnasal Drip Syndrome (PNDS), Asthma, and Gastroesophageal Reflux Diseases (GERD) are the vast majority etiology of chronic cough in non-smoker adult with normal chest X-ray. The clinical investigations that should be performed are spirometry pre-post bronchodilator and bronchoprovocation testing for asthma; plain sinus radiograph and or computed tomographic imaging of the sinus for PNDS due to sinusitis; gastro-intestinal investigation 24 hours oesophageal pH monitoring and upper gastrointestinal endoscopy for GERD.   Keywords: chronic cough, postnasal drip syndrome, asthma, gastroesophageal reflux disease
Kepatuhan Berobat pada Pasien Asma Tidak Terkontrol dan Faktor-Faktor yang Berhubungan Ferliani, Ferliani; Sundaru, Heru; Koesnoe, Sukamto; Shatri, Hamzah
Jurnal Penyakit Dalam Indonesia Vol. 2, No. 3
Publisher : UI Scholars Hub

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Pendahuluan. Mencapai kontrol asma masih merupakan tujuan yang sulit dicapai sebagian besar pasien meskipun telah tersedia pedoman manajemen asma internasional dan terapi yang terbukti efektif. Tingkat kontrol asma yang rendah diantaranya disebabkan kepatuhan terhadap pengobatan yang rendah. Hingga saat ini faktor-faktor yang berhubungan dengan kepatuhan berobat pasien asma tidak terkontrol masih sedikit diteliti. Penelitian ini bertujuan mengetahui profil kepatuhan berobat pada pasien asma tidak terkontrol dan hubungan antara faktor terkait pasien, faktor terkait penyakit, faktor terkait pengobatan, faktor terkait sosial ekonomi dan faktor terkait sistem pelayanan kesehatan terhadap kepatuhan berobat pasien asma tidak terkontrol. Metode. Penelitian potong lintang terhadap pasien asma tidak terkontrol yang datang ke poliklinik alergi dan imunologi RSCM dari bulan Februari 2012 hingga Mei 2012. Semua pasien asma yang memenuhi kriteria dilakukan anamnesis, pemeriksaan fisis lengkap, pengisian kuesioner, tes kontrol asma, tes Beck Depression Inventory dan Asthma General Knowledge Questionnaire. Analisis awal hubungan kepatuhan dengan faktor-faktor yang diteliti menggunakan uji Chi-square. Kemudian dilanjutkan dengan regresi logistik untuk setiap variabel yang bermakna. Hasil. Dari 125 pasien asma tidak terkontrol didapatkan kepatuhan rendah sebesar 56 %. Dilakukan analisis bivariat terhadap faktor-faktor yang berhubungan dengan kepatuhan yaitu usia, pendidikan, pengetahuan asma, penghasilan, depresi, sediaan obat yang digunakan, keyakinan pasien terhadap dokter, asuransi kesehatan dan hubungan keluarga dan didapatkan pengetahuan bermakna dengan p=0,001 (IK 1,939-24,789). Kemudian dilakukan regresi logistik didapatkan pengetahuan paling berpengaruh terhadap kepatuhan (p=0,003) dengan OR 6,933 (IK 1,939-24,789) Simpulan. Kepatuhan berobat pada pasien asma tidak terkontrol masih rendah dengan pengetahuan merupakan faktor yang berhubungan dengan kepatuhan.
Prevalence and Predictors of Atopy in HIV/AIDS Patients Tesiman, Jimmy; Sundaru, Heru; Karjadi, Teguh H.; Setiati, Siti
Jurnal Penyakit Dalam Indonesia Vol. 3, No. 2
Publisher : UI Scholars Hub

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Introduction. HIV infection attacks the center of immune control system resulting opportunistic infection, malignancy and death. Immune system dysregulation plays the central role in the progression of the disease. Some studies reported that HIV-infected patient prone to have allergic disease such as sinusitis, asthma and atopic dermatitis. Elevated serum immunoglobulin E (IgE) and increased prevalence of atopy had also been reported in HIV-infected patient. Methods. A cross sectional study was performed in 92 HIV-infected persons and 90 non-HIV persons. Atopy diagnosis was based on immediate hypersensitivity to six common aeroallergen using skin prick test. CD4 cell count, total serum immunoglobulin level and medical history were taken. Results. Among total of 92 HIV/AIDS patients and 90 non-HIV persons, there were 65 males (70.7%) and 27 female (29.3%) in HIV group and 40 males (44.4%) and 50 females (55.6%) in non-HIV group. Age of all subjects range from 20 to 55 years old, mean age of HIV-infected patients was 29.3 (SD 5.7) years while mean age of controls was 27.9 (4.5) years old. Based on HIV route transmission, there were 56.5% subjects infected from intravenous drug user, 38% from heterosexual intercourse and 5.5% subjects had both risk. CD4+ lymphocyte counts of the subject range from 2-674 cells, median 160 cells/uL. Serum total IgE levels range from 3-20.000 IU/mL with median 283.5 IU/mL. Atopy was higher in subjects with HIV than non-HIV (p= 0,001). The most common aeroallergen is Dermatophagoides farinae (50%) and Dermatophagoides pteronyssinus (30%). There was a negative correlation between CD4+ lymphocyte count and total IgE level (r=-0,544, p<0,001), but there is no relation between gender, HIV route of transmission, allergic history in family and CD4+ lymphocyte count with atopy. Conclusions. Prevalence of atopy based on skin prick test among HIV/AIDS patients was higher than non-HIV group. There was a negative correlation between CD4+ lymphocyte count and total IgE level.
Co-Authors Ari Fahrial Syam E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Ferliani Ferliani, Ferliani Jimmy Tesiman, Jimmy Siti Setiati Sukamto Koesnoe Teguh H Karjadi, Teguh H Teguh H. Karjadi, Teguh H. Wulyo Rajabto