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Supardjan Amir Margono
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Medicine & Pharmacology

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SINTESIS DIASETIL GAMAVUTON-0 DENGAN MENGGUNAKAN ASETIL KLORIDA SEBAGAI ACYLATING AGENT Ridho Nugroho Zendrato; Supardjan Amir Margono
Jurnal Ilmiah Farmasi Vol. 2 No. 2 (2005)
Publisher : Universitas Islam Indonesia

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Abstract

ABSTRACTGamavuton-0 is a curcumin-like compound, which is more stable than curcumin and stillhas an antioxidant property. The objective of synthesis of diacetyl gamavuton-0 (diAcGVT-0) is toyield the product that is more lipophile than GVT-0. Synthesis of diAcGVT-0 has been done byreacting GVT-0 with acetyl chloride as an acylating agent and tertiary amines as primary bases.DiAcGVT-0 was formed as the major product of synthesis and the product was not pure. Structureelucidation using UV-Vis,1H-NMR and MS spectra showed that the main product was diAcGVT-0.Key words : diacetyl gamavuton-0, acetyl chloride, acylating agent, lipophile
Co-Authors Ridho Nugroho Zendrato