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M Angelina
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology

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UJI AKTIVITAS EKSTRAK DAN FRAKSINASI DAUN BRUCEA JAVANICA (Merril) SECARA INVITRO Megawati Megawati; M Angelina
Jurnal Kimia Terapan Indonesia Vol 12, No 2 (2010)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3381.984 KB) | DOI: 10.14203/jkti.v12i2.214

Abstract

Brucea javanica (Merril) is a tropical plant widely grown in Indonesia, Brucea javanica has a bitter taste efficacious to reduce the heat and remove toxins, lethal parasites, anti-anti-dysentery and malaria. Chemical compounds contained in many of which have bioactivity. Antidiabetic test has been performed with a-glucosidase method, anti-oxidant test method "DPPH free radical scavenger" and BSLT toxicity test method (Brine Shrimp Lethality Test) of ethanol extractB.javanica. In the ethanol extract of leaves of the partition B.javanica performed using hexane, ethyl acetate and butanol. Then test each fraction in vitro activity. Test results showed that activity of ethylacetate is active as an anti-oxidant with IC50 value of 89,75 ppm and 7,52 ppm LC50 toxic values while antidiabetic did not have activites.Keyword : Antidiabetic, anti-oxidant, toxicity, a-glukosidase, DPPH, Brine Shrimp Lethality Test, Brucea Javanica(Merril).
ISOLASI DAN IDENTIFIKASI SENYAWA FLAVON DARI EKSTRAK ETIL ASETAT BRUCEA JAVANICA Merrill Megawati Megawati; A Darmawan; M Angelina; S Fajriah; M Hanafi; P D Lotulung
Jurnal Kimia Terapan Indonesia Vol 13, No 2 (2011)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4208.568 KB) | DOI: 10.14203/jkti.v13i2.138

Abstract

Buah Makasar (Brucea javanica Merrill)is a wild ornamental plant and one of the traditional medicine plants. Isolation andpurification of ethyl acetate extract of B.javanica using silica gel column chromatography with ethyl acetatem-hexane as a mobile phase gradually obtained a pure compound as yellow crystals. It was identified by using infrared spectrophotometer (IR), LC-MS (liquid chromatography mass spectrometer) and ID- and 2D-NMR (nuclear magnetic resonance), compound a identified as 6-hydroxy-2-(3,4,5-trihydroxyphenyl}-4H-chromen-4-one, a flavones compound with molecular formula Cl5HI006 and molecular weight of 287.18 m/z.Keywords: Brucea javanica Merrill, buah makasar, flavones,6-hydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one
AKTIVITAS ANTIDIABETES EKSTRAK AIR Coriandrum Sativum PADA MENCIT JANTAN S. D.S Banjarnahor; I.D Dewijanti; M Angelina; Salahudin Salahudin
Jurnal Kimia Terapan Indonesia Vol 11, No 2 (2009)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2233.687 KB) | DOI: 10.14203/jkti.v11i2.161

Abstract

Antidiabetic activity of aqueous extract from coriandrum sativum had been evaluated by using glucose tolerance test in mice. Mice were divided into five groups randomly and each group consists of six animals. In the glucose tolerance test on mice, 30, 60, 120 and 180 minutes after the administration of the extract at a dose of 8 mg/kgbb, serum glucose concentration decreased by 17.07%, 26.31%, 31.3% and 32.55% respectively. Antidiabetic activity of theextract showed no significant changes to that of control group (p<0.05).Keywords : Coriandrum sativum, water extract, glucose tolerance test, blood glucose level.
Co-Authors A Darmawan I.D Dewijanti M Hanafi Megawati Megawati Megawati Megawati P D Lotulung S Fajriah S. D.S Banjarnahor Salahudin Salahudin