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Boima Situmeang

Sekolah Tinggi Analis Kimia Cilegon, Cilegon, Indonesia

Author-ID : 3951452

Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science

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Triterpenoid compound from metanol extract of mangrove leaves (Sonneratia alba) and anti-cholesterol activity test Weny J.A Musa; Nurhayati Bialangi; Boima Situmeang; Saronom Silaban
Jurnal Pendidikan Kimia (JPKim) Vol 11, No 1 (2019): April
Publisher : Pascasarjana Universitas Negeri Medan

Mangrove plant (Sonneratia alba) is easily found in West and North Indonesia. Mangrove plant has the potential of being a herb medicine. Mangrove plant variously used in ethnomedicine to treat various deseases like wounds, diarrhea, and fever. In previously sutudy, leaf extract of mangrove plants reported have anti-cholesterol activity. This plant is widely used to treat various deseases like wounds, diarrhea, and fever. The purpose of this study was to isolate triterpenoid compound from the ethyl acetate fraction of mangrove leaves and anticholesterol activity test. Extraction was done by maceration method using methanol 96% as solvent. Isolation was carried out by column chromatography using a combination of n-hexane, ethyl acetate, and methanol solvents. The elucidation of the structure was determined by analysis of IR, 1H-NMR, 13C-NMR, 2D-NMR, and MS spectroscopies as well as by comparisons with the literature. Anticholesterol activity test was carried out in vitro. The results showed that triterpenoid compounds (lupeol) were able to reduce cholesterol from concentrations of 5, 10, 20, 40, 60, and 80 ppm are 13.7; 29.4; 49.0; 60,1; 70.2; and 77.0% respectively. Therefore, isolates compound (lupeol) have anti-cholesterol activity.Keywords:Anti-cholesterol; mangrove; triterpenes

Methanol extract from kesambi (Schleichera oleosa (L.) oken) stem bark as a natural antioxidant to increase crude palm oil (CPO) quality Weny J A Musa; Nurhayati Bialangi; Diky Kurniawan; M Amrin Sunardi; Ninik Triayu susparini; Sriwijayanti Sriwijayanti; Boima Situmeang
Jurnal Pendidikan Kimia (JPKim) Vol 13, No 3 (2021): December
Publisher : Pascasarjana Universitas Negeri Medan

The content of active compounds in methanol extract of kesambi stem bark (Scheleicera oleosa) is known to have good antioxidant activity. Methanol extract of kesambi stem bark contain flavonoid and fenolic compounds. The purpose of this study was to evaluate the methanol extract of kesambi in inhibiting the oxidation of crude palm oil (CPO). In this study, the extraction of kesambi stem bark was carried out with methanol solvent. Antioxidant activity test of methanol extract of kesambi using the DPPH method. The parameters observed were free fatty acids (FFA) values, acids value, and DOBI (Deterioration of Bleachability Index). The used concentration of natural antioxidant were 200; 400; 600; 800 and 1000 ppm. Based on the results of this study, the natural antioxidant of methanol extract of Kesambi stem bark (Schleichera oleosa) can reduce levels of free fatty acid numbers, acid value, and DOBI value. Actioxidant activity methanol extract of kesambi stem bark shown IC50 42.092 ppm. The lowest FFA levels and acid numbers were obtained from samples with addition of 1000 ppm natural antioxidants with free fatty acid (4.1%), acid value (7.7 mg KOH/g) while the DOBI value increased to 1.331. Furthermore, FFA value meets the CPO quality standard, according to SNI-01-2901-2006. Keywords: Crude palm oil, antioxidant, free fatty acid (FFA), acid value

Antibacterial activity and phytochemical screening of Kesambi (Sapindaceae) against Eschericia coli and Staphylococcus aureus Boima Situmeang; Agus Malik Ibrahim; Nurhayati Bialangi; Weny J.A Musa; Saronom Silaban
Jurnal Pendidikan Kimia (JPKim) Vol 11, No 1 (2019): April
Publisher : Pascasarjana Universitas Negeri Medan

Kesambi plant (Schleichera oleosa) is a medicinal plant belongs to family Sapindaceae, commonly found in tropical and subtropical regions of the world. In Indonesia, kesambi plants can be found in Java and Bali island. The purpose of this study is to extraction and antibacterial activity test of steam bark extract of kesambi against Escherichia coli and Staphylococcus aureus. Extraction was done by maceration method using n-hexane, ethyl acetate and methanol. Antibacerial test using Kirby bauer method by measure inhibition zone. Phytochemical screening shown that n-hexane extract contain triterpenes and steroid compounds. Ethyl acetate extract contain triterpenes, flavonoid, steroid, and fenolic compounds. Methanol extract contain flavonoid, fenolic and triterpenes compounds. Inhibition zone of n-hexane, ethyl acetate and methanol extracts against E. coli and S. aureus at concentration of 5000 µg/mL showed 4.4; 7.9; 4.6 mm and 4.7; 8.9; 4.5 respectively, while amoxicillin and ciprofloxacin as positive control at concentration of 100 µg/mL showed 6.9 and 7.1 mm respectively. Kesambi extract have potential as antibacterial against E. coli and S. aureus.Keywords:Kesambi; antibacterial; Eschericia coli; Staphylococus aureus

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