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All Journal Majalah Farmaseutik
T.N. Saifullah Sulaiman
Fakultas Farmasi, Universitas Gadjah Mada Yogyakarta
Medicine & Pharmacology

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Optimation of Avicel PH 102 with Cab-O-Sil M-5P Ratio and Crospovidone Concentration on Liquisolid System Piroxicam Tablet T.N. Saifullah Sulaiman; Rani Puspita; Mutmainah Mutmainah
Majalah Farmaseutik Vol 13, No 1 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (425.864 KB) | DOI: 10.22146/farmaseutik.v13i1.38466

Abstract

Piroxicam is slightly soluble, so it should be developed in a liquisolid system of tablet dosage form to increase its solubility in gastrointestinal tract. Factorial design was applied to optimize the formula of liquisolid system piroxicam tablet by using four formulas: run  I (18%A-2%B), run II (45%A-2%B), run III (18%A-5%B), and run IV (45%A-5%B). Component A is the ratio of Avicel PH 102 with Cab-O-Sil M-5P whether B is the concentration of crospovidone. Optimum formula was determined by superimposed contour plot from various parameters: hardness, friability, disintegrating time, and dissolution concentration (C45) using Design Expert software. Based on superimposed contour plot, optimum formula area was obtained in the range of 18-45 of Avicel PH 102 with Cab-O-Sil M-5P ratio and 2-5% of crospovidone concentration.
Co-Authors Mutmainah Mutmainah Rani Puspita