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All Journal Majalah Farmaseutik Jurnal Perikanan Universitas Gadjah Mada
Sudarsono Sudarsono
Fakultas Farmasi Universitas Gadjah Mada
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology

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Effect of Forms of Pharmaceutical Preparations on Antibacterial Activity of Red Betel Oil (Piper crocatum Ruiz & Pav.) Marchaban Marchaban; Anisa Ragil Handayani; Elsa Putri Kartika; Sudarsono Sudarsono
Majalah Farmaseutik Vol 15 No 1, (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (490.679 KB) | DOI: 10.22146/farmaseutik.v15i1.45015

Abstract

The Red Sirih Essential Oil (RSEO) which be obtained from red betel leaf (Piper crocatum Ruiz & Pav.) by water and vapour distillation has potential as antibacterial activity. Formulation of an active pharmaceutical ingredient to become a pharmaceutical dosage form can generally modify their activity. The aim of the study is to proof the influence of dosage forms to the activity of RSEO. The study was done by formulating the RSEO to become emulsion, microemulsion and solubilisation dosage forms, and then, their antibacterial activity againt Escherichia coli ATCC 25922 by microdilution method of 1.25% using ELISA reader at 570 nm. The results showed that formulation reduced antibacterial activity. The raw RSEO had a Bacterial Growth Inhibition (BGI) of 66.59%, whereas microemulsion had 49.58%, emulsion had 17.45%, and solubilisation had 0% of BGI, that mean lost its antibacterial activity.
Toksisitas dan Aktivitas Anti-mikroba Ekstrak Etanol Bunga Karang dari Perairan Pulau Tabuhan Banyuwangi dan Pulau Menjangan Bali Barat Erna Prawita Setyowati; Umar Anggara Jenie; Sudarsono Sudarsono; Broto Kardono
Jurnal Perikanan Universitas Gadjah Mada Vol 9, No 2 (2007)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfs.26

Abstract

The purpose of the research were to determine the toxicity and antimicrobial activity of ethanolic extract of sponges collected from Tabuhan Island, Banyuwangi and Menjangan Island, West Bali. Extracts were made by maceration of the sponge samples for 3 x 24 hours. The toxicity test was carried out by Brine Shrimp Lethality Test (BST) with 48 hours-old Artemia sp. The effect of ethanolic extract was identified by determining the mortality of Artemia sp. and LC50 of each extract was analyzed by using probit analysis. Antimicrobial activity was tested by agar diffusion method. The result showed that several ethanolic extracts exhibited toxicity to Artemia sp. The toxicity test showed that extract of sponge code B43 was the most toxic with the LC50 of 8.4 µg/ml. Antimicrobial activity test exhibited that ethanolic extract of sponge with code numbers B2, B57, B61 dan W5 were active against Candida ablicans, while the axtracts of sponge with code numbers B9, B35, B47, B51 (Liosina sp.), B57, B61, B63 and W11 were active against Staphylococcus aureus. One ethanolic extract from sponge with code number B57 exibited activity against Eschericia coli.
Co-Authors Anisa Ragil Handayani Broto Kardono Elsa Putri Kartika Erna Prawita Setyowati Marchaban Marchaban Umar Anggara Jenie