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Sri Noegrohati
Faculty of Pharmacy, Sanata Dharma University, Yogyakarta 55282 Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281
Chemical Engineering, Chemistry & Bioengineering Chemistry

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Molecular Dynamics Simulations and Empirical Observations on Soy Lecithin Liposome Preparation Rini Dwiastuti; Muhammad Radifar; Marchaban Marchaban; Sri Noegrohati; Enade Perdana Istyastono
Indonesian Journal of Chemistry Vol 16, No 2 (2016)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (235.945 KB) | DOI: 10.22146/ijc.21167

Abstract

Soy lecithin is a phospholipid often used in liposome formulations. Determination of water and phospholipid composition is one of the problems in the liposome formulation. This study is using molecular dynamics simulation and empirical observation in producing liposome preparations. Phospholipids 1,2-dilauroyl-sn-glycero-3-phosphoethanolamine (DLPE) were objected in molecular dynamics simulations using Coarse Grained Molecular Dynamics (CGMD) approaches. The result showed that the molecular dynamic simulations could be employed to predict the liposome size. The molecular dynamic simulations resulted in liposome size of 71.22 ± 2.54 nm, which was located within the range of the liposome size resulted from the empirical observations (95.99 ± 43.02 nm). Moreover, similar liposome forms were observed on both results of molecular dynamics simulations and empirical approaches.
Co-Authors Enade Perdana Istyastono Marchaban Marchaban Muhammad Radifar Rini Dwiastuti