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Jalifah Latip
School of Chemical Sciences & Food Technology, Faculty of Science and Technology, Universi
Chemical Engineering, Chemistry & Bioengineering Chemistry

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RESVERATROL DIMERS FROM STEM BARK OF Hopea gregaria AND THEIR CYTOTOXIC PROPERTIES Sahidin Sahidin; Euis Holisotan Hakim; Yana Maolana Syah; Lia Dewi Juliawaty; Sjamsul Arifin Achmad; Laily Bin Din; Jalifah Latip
Indonesian Journal of Chemistry Vol 8, No 2 (2008)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (266.862 KB) | DOI: 10.22146/ijc.21629

Abstract

Six resveratrol dimers have been isolated from the stem bark of H. gregaria, ampelopsin A (1), balanocarpol (2), ε-viniferin (3), hopeafuran (4), heimiol A (5), and parviflorol (6). The structures of these compounds were determined based on spectroscopic evidence such as UV, IR, 1-D, 2-D NMR and comparison with the reported data. These compound inventions are strengthen conclusion that Hopea tends to produce resveratrol dimers. Biological activity of those compounds against murine leukemia P-388 cells showed that ε-viniferin (3) is the most active compound with IC50 value 5.1 ± 0.3 μg/mL.
Co-Authors Euis Holisotan Hakim Laily Bin Din Lia Dewi Juliawaty Sahidin Sahidin Sjamsul Arifin Achmad Yana Maolana Syah