RESVERATROL DIMERS FROM STEM BARK OF Hopea gregaria AND THEIR CYTOTOXIC PROPERTIES

Sahidin Sahidin (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Haluoleo University, Kampus Baru Anduonohu, Kendari, South East Sulawesi)
Euis Holisotan Hakim (Natural Products Research Group, Departement of Chemistry, Institut Teknologi Bandung, Jalan Ganeca 10 Bandung 40132)
Yana Maolana Syah (Natural Products Research Group, Departement of Chemistry, Institut Teknologi Bandung, Jalan Ganeca 10 Bandung 40132)
Lia Dewi Juliawaty (Natural Products Research Group, Departement of Chemistry, Institut Teknologi Bandung, Jalan Ganeca 10 Bandung 40132)
Sjamsul Arifin Achmad (Natural Products Research Group, Departement of Chemistry, Institut Teknologi Bandung, Jalan Ganeca 10 Bandung 40132)
Laily Bin Din (School of Chemical Sciences & Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor D.E)
Jalifah Latip (School of Chemical Sciences & Food Technology, Faculty of Science and Technology, Universi)

Indonesian Journal of Chemistry
Vol 8, No 2 (2008)

Six resveratrol dimers have been isolated from the stem bark of H. gregaria, ampelopsin A (1), balanocarpol (2), ε-viniferin (3), hopeafuran (4), heimiol A (5), and parviflorol (6). The structures of these compounds were determined based on spectroscopic evidence such as UV, IR, 1-D, 2-D NMR and comparison with the reported data. These compound inventions are strengthen conclusion that Hopea tends to produce resveratrol dimers. Biological activity of those compounds against murine leukemia P-388 cells showed that ε-viniferin (3) is the most active compound with IC50 value 5.1 ± 0.3 μg/mL.